Abstract：
:Early electron microscope studies of developing wool and hair established that trichocyte (hard alpha-) keratin fibers have a composite structure in which filaments, subsequently shown to belong to the class of intermediate filaments (IF), were embedded in a matrix of sulfur-rich proteins. These studies also showed that the IF aggregate in a variety of ways to form what have been termed macrofibrils. Assembly into sheets appears to be an important initial factor in aggregation, and in the present contribution the structural principles governing sheet formation are formulated and specific models for the interaction between neighboring IF in a sheet are proposed, based on existing X-ray diffraction, electron microscope, and crosslinking data. All of the trichocyte keratins so far examined by electron microscopy exhibit similar filament/matrix textures and the mechanism of sheet formation proposed here is likely to have general applicability.
journal_name
J Struct Bioljournal_title
Journal of structural biologyauthors
Fraser RD,Parry DAdoi
10.1016/s1047-8477(03)00027-3keywords:
subject
Has Abstractpub_date
2003-05-01 00:00:00pages
319-25issue
2eissn
1047-8477issn
1095-8657pii
S1047847703000273journal_volume
142pub_type
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journal_title：Journal of structural biology
pub_type： 杂志文章
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journal_title：Journal of structural biology
pub_type： 杂志文章
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journal_title：Journal of structural biology
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更新日期：2010-09-01 00:00:00
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journal_title：Journal of structural biology
pub_type： 杂志文章
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journal_title：Journal of structural biology
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pub_type： 杂志文章
doi：10.1016/j.jsb.2008.09.002
更新日期：2008-12-01 00:00:00
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journal_title：Journal of structural biology
pub_type： 杂志文章,评审
doi：10.1016/j.jsb.2007.07.002
更新日期：2007-12-01 00:00:00
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journal_title：Journal of structural biology
pub_type： 杂志文章
doi：10.1006/jsbi.2001.4359
更新日期：2001-08-01 00:00:00
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journal_title：Journal of structural biology
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journal_title：Journal of structural biology
pub_type： 杂志文章
doi：10.1006/jsbi.1994.1014
更新日期：1994-03-01 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of structural biology
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更新日期：2011-03-01 00:00:00
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journal_title：Journal of structural biology
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journal_title：Journal of structural biology
pub_type： 杂志文章
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