Update on progress in the international, multicenter, randomized, controlled trial of corticosteroids after significant head injury (Medical Research Council CRASH Trial).

abstract：PURPOSE OF REVIEW:As incidence of acute lung injury (ALI) increases and case fatality decreases, long-term care of survivors is of public health importance. Previous studies demonstrate that these survivors are at risk for impairment in physical, cognitive and mental health. In this review, we will discuss recent studi...

journal_title：Current opinion in critical care

authors： Hough CL,Herridge MS

更新日期：2012-02-01 00:00:00

abstract：:The purpose of this report is to provide information regarding preparation for disaster management from the perspective of ICU physicians. Both a framework toward ICU preparation for disaster management and a guide to the relevant literature are presented. Our objective is to show that the understanding of disaster pr...

journal_title：Current opinion in critical care

authors： Roccaforte JD,Cushman JG

更新日期：2002-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Although conventional anticonvulsant agents can terminate status epilepticus in most cases, a substantial minority of patients develops medically refractory status and requires more aggressive care. This review explores the options available. RECENT FINDINGS:Increasing numbers of previously unexpecte...

journal_title：Current opinion in critical care

authors： Bleck TP

更新日期：2005-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Mechanical ventilation is a cornerstone of ICU treatment. Because of its interaction with blood flow and intra-abdominal pressure, mechanical ventilation has the potential to alter hepato-splanchnic perfusion, abdominal organ function and thereby outcome of the most critically ill patients. RECENT FI...

journal_title：Current opinion in critical care

authors： Jakob SM

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The risk of adverse outcome in patients undergoing major surgery is affected both by cardiorespiratory fitness, and the presence and severity of comorbidities. Accurate risk stratification is essential for the identification of patients who may benefit from specific perioperative management strategies...

journal_title：Current opinion in critical care

authors： Moonesinghe SR,Mythen MG,Grocott MP

更新日期：2009-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews the current literature dealing with pathophysiology, diagnostics, bleeding management, and thromboprophylaxis in patients with acute and chronic liver dysfunction. RECENT FINDINGS:Routine coagulation tests such as prothrombin time and International Normalized Ratio (INR) are not ...

journal_title：Current opinion in critical care

authors： Schaden E,Saner FH,Goerlinger K

更新日期：2013-04-01 00:00:00

abstract：:Increased knowledge of the mechanisms that determine respiratory failure has led to the development of new technologies aimed at improving ventilatory treatment. Proportional assist ventilation and neurally adjusted ventilatory assist have been designed with the goal of improving patient-ventilator interaction by matc...

journal_title：Current opinion in critical care

authors： Navalesi P,Costa R

更新日期：2003-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Appropriate measurements of success in trauma systems are evolving. We review the rationale behind prior trauma and rehabilitation outcomes measures, and how they have led to the current rehabilitation tools in use today. In addition, we review the difficulties with current methods and future improvem...

journal_title：Current opinion in critical care

authors： Horwitz DA,Schuerer DJ

更新日期：2008-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The use of neuromuscular blocking agents (NMBAs) in patients with acute respiratory distress syndrome (ARDS) and acute lung injury remains controversial, although frequent. This review analyzes the effects of NMBAs on thoracopulmonary mechanics, gas exchange, patient outcome and their potential advers...

journal_title：Current opinion in critical care

authors： Forel JM,Roch A,Papazian L

更新日期：2009-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Antimicrobials are very commonly used drugs in the intensive care setting. Extensive research has been conducted in recent years to describe their pharmacokinetics/pharmacodynamics in order to maximize the pharmacological benefit and patient outcome. Translating these new findings into clinical practi...

journal_title：Current opinion in critical care

authors： Tsai D,Lipman J,Roberts JA

更新日期：2015-10-01 00:00:00

abstract：:Reactive oxygen species are reactive, partially reduced derivatives of molecular oxygen (O 2 ). Important reactive oxygen species in biologic systems include superoxide radical anion, hydrogen peroxide, and hydroxyl radical. Closely related species include the hypohalous acids, particularly hypochlorous acid; chlorami...

journal_title：Current opinion in critical care

authors： Fink MP

更新日期：2002-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The paucity of effective therapeutic interventions in patients with the acute respiratory distress syndrome (ARDS) combined with overwhelming evidence on the importance of timely implementation of effective therapies to critically ill patients has resulted in a recent shift in ARDS research. Increasin...

journal_title：Current opinion in critical care

authors： Festic E,Kor DJ,Gajic O

更新日期：2015-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Status epilepticus has a high morbidity and mortality. There are little definitive data to guide management; however, new recent data continue to improve understanding of management options of status epilepticus. This review examines recent advancements regarding the critical care management of status...

journal_title：Current opinion in critical care

authors： Bauerschmidt A,Martin A,Claassen J

更新日期：2017-04-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we focus on the dual face of antibiotic therapy in the critically ill that must harmonize the need for early, appropriate and adequate antibiotic therapy in the individual-infected patient with the obligation to limit antibiotic selection pressure as much as possible to preserve its fu...

journal_title：Current opinion in critical care

authors： Depuydt P,De Waele JJ

更新日期：2019-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Tissue hypoperfusion is a common pathophysiologic process leading to multiple-organ dysfunction and death. An important goal of hemodynamic monitoring is the early detection of inadequate tissue perfusion and oxygenation. The use of simple, noninvasive monitoring techniques has the advantage of facili...

journal_title：Current opinion in critical care

authors： Creteur J

更新日期：2008-06-01 00:00:00

abstract：PURPOSE OF REVIEW:We report on recent advances and achievements on the use of extracorporeal gas exchange for long-term application in the therapy of critically ill patients with various forms of respiratory failure. RECENT FINDINGS:The most important results regarding the use of extracorporeal gas exchange are expect...

journal_title：Current opinion in critical care

authors： Pesenti A,Zanella A,Patroniti N

更新日期：2009-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Treatment protocols targeting the rapid administration of appropriate antibiotics and hemodynamic support are now recognized as a key measure in the initial care of patients presenting with severe sepsis and septic shock. Strong evidence exists showing that time parameters, particularly in the emergen...

journal_title：Current opinion in critical care

authors： Nobre V,Sarasin FP,Pugin J

更新日期：2007-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Research and studies related to the long-term consequences of intensive care are increasing. This review focuses on some of the most recent knowledge in this field. RECENT FINDINGS:Still studies regarding the health-related quality of life (HRQOL) in survivors after intensive care are frequently publ...

journal_title：Current opinion in critical care

authors： Flaatten H

更新日期：2010-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will discuss the rationale and clinical utility of percutaneous left ventricular assist devices in the management of patients with cardiogenic shock. RECENT FINDINGS:Left ventricular assist devices maintain partial or total circulatory support in case of severe left ventricular failure. C...

journal_title：Current opinion in critical care

authors： Windecker S

更新日期：2007-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review describes the current intensive care management of acute liver failure (ALF) and the latest evidence for emerging therapies. RECENT FINDINGS:Mortality from ALF continues to improve and in some cases, medical therapy can negate the need for liver transplantation because of protocolized man...

journal_title：Current opinion in critical care

authors： Trovato FM,Rabinowich L,McPhail MJW

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To investigate the impact of critical illness polyneuropathy and critical illness myopathy on short-term and long-term patient outcome. RECENT FINDINGS:In the acute-care setting, critical illness polyneuropathy and critical illness myopathy are important causes of acute paralysis in critically ill co...

journal_title：Current opinion in critical care

authors： Latronico N,Shehu I,Seghelini E

更新日期：2005-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Statins are effective lipid-lowering agents used extensively in medical practice. This review summarizes the evidence for statin treatment of cardiovascular patients in the intensive care unit and briefly discusses the role of statins in prevention and treatment of sepsis as a potential future applica...

journal_title：Current opinion in critical care

authors： Merx MW,Weber C

更新日期：2006-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite improved care of multiple injured patients, controversial data about the best time point for decompression and stabilization of spine fractures and spinal cord injuries are published. Some studies even question the value of surgical management. RECENT FINDINGS:In several mostly retrospective ...

journal_title：Current opinion in critical care

authors： Schinkel C,Anastasiadis AP

更新日期：2008-12-01 00:00:00

abstract：PURPOSE OF REVIEW:A significant number of patients hospitalized with heart failure are malnourished. Depletion of micronutrients, which is known to occur in heart failure for a variety of reasons, may contribute to myocardial abnormalities noted in heart failure. In this review, we focus on nutritional supplementation ...

journal_title：Current opinion in critical care

authors： Sarma S,Gheorghiade M

更新日期：2010-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Selenium is a trace element essential to human health. Critical illness is associated with the generation of oxygen free radicals resulting in a condition of oxidative stress. Supplementing critically ill patients with antioxidant nutrients may improve survival. Selenium levels can be low due to redis...

journal_title：Current opinion in critical care

authors： Geoghegan M,McAuley D,Eaton S,Powell-Tuck J

更新日期：2006-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Acute liver failure (ALF) is associated with significant mortality. Although specific therapies may be available, the evidence base for these and for many aspects of supportive therapy has been slow to emerge. Liver transplantation continues to be a cornerstone of treatment, and the management of ALF,...

journal_title：Current opinion in critical care

authors： Willars C

更新日期：2014-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Vascular permeability is traditionally explained by Starling's principle, describing two opposing forces across the endothelial cell line to maintain compartments in balance. Several contradictions to this principle have recently questioned its validity. RECENT FINDINGS:Hydraulic conductivity is kept...

journal_title：Current opinion in critical care

authors： Jacob M,Chappell D

更新日期：2013-08-01 00:00:00

abstract：PURPOSE OF REVIEW:End-of-life care and communication deficits are important sources of conflicts within ICU teams and with patients or families. This narrative review describes recent studies on how to improve palliative care and surrogate decision-making in ICUs and compares the results with previously published liter...

journal_title：Current opinion in critical care

authors： Wiedermann CJ,Lehner GF,Joannidis M

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes current understanding of the pathophysiology of cardiogenic pulmonary edema, its causes and treatment. RECENT FINDINGS:The pathobiology and classification of pulmonary edema is more complex than the hydrostatic vs. permeability dichotomy of the past. Mechanisms of alveolar flui...

journal_title：Current opinion in critical care

authors： Ingbar DH

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Acute coagulopathy of trauma has only been described relatively recently. Developing early in the postinjury phase, it is associated with increased transfusion requirements and poor outcomes. This review examines the possible initiators, mechanism and clinical importance of acute coagulopathy. RECENT...

journal_title：Current opinion in critical care

authors： Brohi K,Cohen MJ,Davenport RA

更新日期：2007-12-01 00:00:00