Abstract:
PURPOSE OF REVIEW:To investigate the impact of critical illness polyneuropathy and critical illness myopathy on short-term and long-term patient outcome. RECENT FINDINGS:In the acute-care setting, critical illness polyneuropathy and critical illness myopathy are important causes of acute paralysis in critically ill comatose patients, and may cause inappropriately pessimistic prognoses. Duration of weaning from artificial ventilation is 2 to 7 times greater in patients with critical illness polyneuropathy than in patients without critical illness polyneuropathy. After intensive care unit and hospital discharge, many patients diagnosed with critical illness polyneuropathy or critical illness myopathy are reported to complain of profound muscle weakness. Chronic disability was a common finding among them. Complete functional recovery with patients regaining the ability to breathe spontaneously and to walk independently was reported in 180 of 263 patients (68.4%); severe disability with tetraparesis, tetraplegia, or paraplegia was reported in 74 patients (28.1%). Persisting milder disabilities were common even in patients with complete functional recovery, and included reduced or absent deep tendon reflexes, stocking and glove sensory loss, muscle atrophy, painful hyperesthesia, and foot drop. An association of critical illness polyneuropathy and critical illness myopathy with increased intensive care unit and hospital mortality has been demonstrated only in selected intensive care unit populations; data are insufficient to demonstrate any association with long-term mortality. SUMMARY:Intensive care unit-acquired critical illness polyneuropathy and critical illness myopathy influence the evaluation of acutely ill comatose patients and may instigate unreasonably pessimistic prognosis. Critical illness polyneuropathy and critical illness myopathy are an important cause of difficult weaning of patients from the ventilator and of persisting muscle weakness and disability after intensive care unit discharge.
journal_name
Curr Opin Crit Carejournal_title
Current opinion in critical careauthors
Latronico N,Shehu I,Seghelini Edoi
10.1097/01.ccx.0000168530.30702.3ekeywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
381-90issue
4eissn
1070-5295issn
1531-7072pii
00075198-200508000-00017journal_volume
11pub_type
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更新日期:2018-12-01 00:00:00
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journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
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更新日期:2014-04-01 00:00:00
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journal_title:Current opinion in critical care
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更新日期:2012-08-01 00:00:00
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更新日期:2017-04-01 00:00:00
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journal_title:Current opinion in critical care
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doi:10.1097/MCC.0b013e3282f6a3f9
更新日期:2008-04-01 00:00:00
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journal_title:Current opinion in critical care
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更新日期:2009-08-01 00:00:00
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journal_title:Current opinion in critical care
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更新日期:2013-12-01 00:00:00
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更新日期:2004-02-01 00:00:00
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