[Characteristics of lung cancer in patients exposed to silica at work. A comparison of exposed and non-exposed individuals].


INTRODUCTION:In 1977 silica was listed as a group 1 carcinogen (demonstrated in humans) by the International Agency for Research on Cancer. However, conflicting results from various studies have kept debate alive as to its carcinogenic capacity. The interest of this debate lies in the large number of workers exposed to silica. OBJECTIVE:To analyze the differential characteristics of lung cancer among silica exposed and silica non-exposed individuals, to identify indirectly a possible carcinogenic effect of silica. METHODS:For all males with a diagnosis of lung cancer over a period of 22 consecutive months at the National Silicosis Institute (Oviedo, Spain), we recorded work history, age, smoking habits, spirometry, the presence of pneumoconiosis and histology. RESULTS:Comparing the results for silica exposed and non-exposed individuals, we found significant differences for age (63.7 8.8 and 66.7 8.6 y, respectively; p < 0.05), smoking (44.1 22.4 and 48.9 22.3 packs/year; p < 0.05) and a Tiffeneau index under 70% (in 78% of exposed vs. 55% of non-exposed patients; p < 0.05). No significant differences in histology, signs and symptoms or radiographs were observed between the two groups. In the multifactorial analysis in function of age of onset, exposure to silica continued to be an independent predictor. CONCLUSION:Our results show that the clinical and radiological signs and histology of patients exposed or non-exposed to silica did not differ. However, lung cancer appears earlier among individuals with work-related exposure to silica and lower rates of tobacco smoking, suggesting some carcinogenic effect for silica.


Arch Bronconeumol


Barrenechea MJ,Martínez C,Ferreiro MJ,Paramá A,Tardón A,Rego G





Has Abstract


2002-12-01 00:00:00














  • Characteristics of asthma patients admitted to an intermediate respiratory care unit.

    abstract:INTRODUCTION:Intermediate respiratory care units (IRCU) provide continuous monitoring and non-invasive mechanical ventilation (NIMV) in patients with severe respiratory failure who are usually admitted to intensive care units (ICU). The usefulness of IRCU in managing severe asthma exacerbations has never been evaluated...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Núñez B,Fiorentino F,Kersul A,Belda S,García S,Gutiérrez C,Sala E,Cosío B

    更新日期:2013-04-01 00:00:00

  • [Clinicopathological features of solitary fibrous tumors of the pleura: a case series and literature review].

    abstract::We assessed the clinicopathological features of solitary fibrous tumors of the pleura in a case series comprising 30 patients (20 women, 66.6%) with a mean age of 58.39 years. Forty-five percent of the cases were asymptomatic. In 70% of the cases the tumors arose in the visceral pleura. Twenty percent presented multip...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Sánchez-Mora N,Cebollero-Presmanes M,Monroy V,Carretero-Albiñana L,Herranz-Aladro M,Alvarez-Fernández E

    更新日期:2006-02-01 00:00:00

  • [Impact of exacerbations and admissions in chronic obstructive pulmonary disease].

    abstract::During the natural history of patients with chronic obstructive pulmonary disease (COPD), an increase in symptom severity can occur, called exacerbated COPD (ECOPD), sometimes requiring hospital admission. Although there is ongoing debate on the definition of ECOPD--leading to a lack of homogeneity in the numerous stu...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Arnedillo Muñoz A

    更新日期:2010-01-01 00:00:00

  • Fatty acid supplements improve respiratory, inflammatory and nutritional parameters in adults with cystic fibrosis.

    abstract:INTRODUCTION AND AIMS:Chronic inflammation plays a major role in lung deterioration in cystic fibrosis (CF) patients and anti-inflammatory strategies have beneficial effects. To study the changes seen after a one-year course of low-dose dietary supplements with a mixture of fatty acids in adult patients with CF in chro...

    journal_title:Archivos de bronconeumologia

    pub_type: 临床试验,杂志文章


    authors: Olveira G,Olveira C,Acosta E,Espíldora F,Garrido-Sánchez L,García-Escobar E,Rojo-Martínez G,Gonzalo M,Soriguer F

    更新日期:2010-02-01 00:00:00

  • [Prognostic factors and outcome of thymectomy in 80 cases of myasthenia gravis].

    abstract:OBJECTIVES:To analyze the results of thymectomy in our series of patients with myasthenia gravis (MG) and to study the influence of the most common prognostic factors. MATERIAL AND METHODS:Eighty MG patients over a period of 23 years underwent thymectomy consecutively in our hospital. Preoperative assessment included ...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Vázquez-Pelillo J,Gil Alonso J,Díaz-Agero P,García Sánchez-Girón J,Roca Serrano R,Díez Tejedor E,Casillas Pajuelo M

    更新日期:2001-04-01 00:00:00

  • [Organizing pneumonia associated with the use of pegylated interferon alfa].

    abstract::Organizing pneumonia is a well-differentiated clinical and histologic entity whose onset is usually subacute with respiratory symptoms and pulmonary infiltrates. Its origin may be unknown (cryptogenic) or it may be associated with various medical conditions, infectious diseases, or drugs. Diagnosis is confirmed by the...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Trullas Vila JC,Padilla López DR,Bisbe Company V,Soler Simón S,Cortés Hausmann P,Bisbe Company J

    更新日期:2008-03-01 00:00:00

  • [Treatment of chronic obstructive pulmonary disease in 5 Latin American cities: the PLATINO study].

    abstract:OBJECTIVE:PLATINO project is a population-based study designed to determine the prevalence of chronic obstructive pulmonary disease (COPD) in São Paulo, Brazil; Mexico City, Mexico; Montevideo, Uruguay; Santiago de Chile, Chile; and Caracas, Venezuela. The objective of this portion of PLATINO was to describe preventive...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,多中心研究


    authors: López Varela MV,Muiño A,Pérez Padilla R,Jardim JR,Tálamo C,Montes de Oca M,Valdivia G,Pertuzé J,Halbert R,Menezes AM,PLATINO Group.

    更新日期:2008-02-01 00:00:00

  • [Management according to the Global Initiative for Asthma guidelines of patients with near-fatal asthma reduces morbidity and mortality].

    abstract:OBJECTIVE:To assess the effect of adequate outpatient care as defined by guidelines of the Global Initiative for Asthma (GINA) on the long-term outcome of near-fatal asthma. PATIENTS AND METHODS:Fifty-three patients who had experienced a near-fatal attack of asthma were treated according to the GINA guidelines and fol...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Rodríguez-Trigo G,Plaza V,Picado C,Sanchis J

    更新日期:2008-04-01 00:00:00

  • [Prevalence and distribution of asbestos lung residue in a Spanish urban population].

    abstract:INTRODUCTION:The purpose of the present study is to analyse the prevalence and distribution of asbestos lung residue in the Barcelona urban population. MATERIAL AND METHODS:Lung autopsy samples were obtained from 35 individuals who had lived in Barcelona. The close family were interviewed in order to rule out asbestos...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Velasco-García MI,Recuero R,Cruz MJ,Panades R,Martí G,Ferrer J

    更新日期:2010-04-01 00:00:00

  • P4 medicine: the future around the corner.

    abstract::Traditional medical practice has been "reactive" (doctor takes part when disease appears). The theoretical (scale free networks and complex systems), technological (high efficiency "omic" technologies) and conceptual (biology systems) advances throughout the last decade, allow us to anticipate the transition to an "an...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Sobradillo P,Pozo F,Agustí A

    更新日期:2011-01-01 00:00:00

  • Clinical audit of patients hospitalized due to COPD exacerbation. MAG-1 Study.

    abstract:UNLABELLED:Hospitalizations for acute exacerbation of COPD (AECOPD) generate high consumption of health resources, frequent readmissions and high mortality. The MAG -1 study aims to identify critical points to improve the care process of severe AECOPD requiring hospitalization. METHODS:Observational study, with review...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,多中心研究


    authors: Escarrabill J,Torrente E,Esquinas C,Hernández C,Monsó E,Freixas M,Almagro P,Tresserras R,en nombre del equipo del Plan Director de las Enfermedades del Aparato Respiratorio (PDMAR) y del grupo colaborador del proyecto MAG-1.

    更新日期:2015-10-01 00:00:00

  • Non-Tuberculous Mycobacteria. An Emerging Threat?

    abstract:INTRODUCTION AND OBJECTIVE:Non-tuberculous mycobacteria (NTM) isolates are becoming more common. The main objective of our study was to establish the number and diversity of NTM species in our region and their distribution according to the source sample, age and gender of the patients, and to analyse clinically signifi...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Martínez González S,Cano Cortés A,Sota Yoldi LA,García García JM,Alba Álvarez LM,Palacios Gutiérrez JJ,en representación de la Red de Laboratorios de Microbiología del SESPA.

    更新日期:2017-10-01 00:00:00

  • [Effects of nasal continuous positive airway pressure on lung function in patients with sleep obstructive apnea syndrome].

    abstract::Sixty-one patients with obstructive sleep apnea syndrome (OSAS), 26 of whom also had chronic obstructive pulmonary disease (COPD), received treatment by nasal continuous positive airways pressure (nCPAP). To evaluate the effects of this device on daytime lung function, we analyzed pulmonary function tests before treat...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Vázquez Oliva R,Cano Gómez S,Capote Gil F,Sánchez Armengol MA,Carmona Bernal C,Castillo Gómez J

    更新日期:1995-01-01 00:00:00

  • [Venous compression ultrasonography of the lower limbs: a diagnostic tool in the hands of pneumologists].

    abstract::Our objective was to study agreement between the compression ultrasound images taken in our respiratory medicine department and the duplex ultrasound images obtained by radiologists at our hospital for patients admitted to our ward with suspected diagnoses of venous thromboembolism.Seventy-eight consecutive patients a...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Arenas Gordillo M,Otero Candelera R,Cayuela Domínguez A,López Campos JL,Barrot Cortés E,González Brazo J,Verano Rodríguez A

    更新日期:2002-04-01 00:00:00

  • Treatment of bronchus intermedius stenosis in lung transplantation with Montgomery T-tube stent. A novel technique.

    abstract::Airway complications after lung transplant are relatively common although the rates vary according to the different studies. Pathogenesis is diverse but the principal mechanism is usually bronchus intermedius ischemia in the post-transplant period. One major complication is bronchial stenosis, with relatively frequent...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Pinillos Robles J,García Luján R,de Pablo Gafas A,de Miguel Poch E

    更新日期:2015-02-01 00:00:00

  • Determination of a low risk group for having metastatic nodules not detected by computed tomography scan in lung metastases surgery.

    abstract:INTRODUCTION:In recent years, there has been debate regarding the diagnostic accuracy of computed tomography (CT) in the identification of lung metastases and the need for lung palpation to determine the number of metastatic nodules. The aim of this study was to determine in which patients the CT scan was more effectiv...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Zabaleta J,Aguinagalde B,Izquierdo JM,Mendoza M,Basterrechea F,Martin-Arruti M,Lobo C,Emparanza JI

    更新日期:2013-12-01 00:00:00

  • [Prognostic value of positive cytology found in pleural lavage of patients with cancer of the lung. Prospective study].

    abstract::Pulmonary neoplasms can deposit malignant cells in the pleural cavity by a variety of mechanisms, depending not only on histological type but also on clinical stage. We investigated the effect on survival rate of a finding of malignant cells in pleural lavage. We also investigated the effect of the presence of pleural...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Arnau Obrer A,Cantó Armengod A,Martín Díaz E,Navarro Ibáñez R,Ramón Capilla M,García Aguado R,Martorell Cebollada M

    更新日期:1996-08-01 00:00:00

  • [Predictors of outcome in blunt chest trauma].

    abstract:INTRODUCTION:Thoracic trauma is often associated with polytrauma. Because mortality is high, the search for prognostic tools is useful. PATIENTS AND METHODS:A total of 108 patients with blunt thoracic trauma, 73 of whom had multiple injuries, were studied in an intensive care unit (ICU). The variables named as potenti...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Virgós Señor B,Nebra Puertas AC,Sánchez Polo C,Broto Civera A,Suárez Pinilla MA

    更新日期:2004-11-01 00:00:00

  • [A study of 73 cases of bronchial tuberculosis].

    abstract::We reviewed 73 cases of bronchial tuberculosis (59 adults and 14 children) diagnosed between 1973 and 2000 using histologic and bacteriologic criteria. The most frequent symptom was cough. Radiographic studies showed an alveolar pattern in 35 cases and obstructive pneumonitis or atelectasis in 28 cases. Endoscopy resu...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Miguel Campos E,Puzo Ardanuy C,Burgués Mauri C,Castella Riera J

    更新日期:2008-05-01 00:00:00

  • [Videothoracoscopy in the surgical treatment of pneumothorax: report of 46 cases].

    abstract::We report our 3-years experience with video-thoracoscopy for pneumothorax. Forty-six endoscopies (34 men, 12 women; mean age 27 +/- 9 years) were performed. Patients were under general anesthesia and intubation was selective. The conventional approach was used, with 3 incisions through which the camera and endoscopic ...

    journal_title:Archivos de bronconeumologia

    pub_type: 临床试验,杂志文章


    authors: Izquierdo JM,Pac J,Casanova J,Mariñán M,Rojo R,Rumbero JC,Vara F

    更新日期:1996-02-01 00:00:00

  • [Isolated laryngeal candidiasis. Description of 2 cases and review of the literature].

    abstract::Infection of the larynx by Candida is rare and usually accompanies lung or disseminated candidiasis. The incidence of isolated laryngeal candidiasis (ILC) is low, although it may be underestimated. We describe 2 patients with ILC confirmed during autopsy: a 45-years-old male with pulmonary fibrosis and a 4-years-old g...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Alba D,Perna C,Molina F,Ortega L,Várquez JJ

    更新日期:1996-04-01 00:00:00

  • [Analysis of respiratory muscle structure and tumor necrosis and insulin-like growth factor expression in chronic obstructive pulmonary disease: are samples valid if obtained during thoracotomy performed because of localized pulmonary neoplasia?].

    abstract:OBJECTIVE:Various methods have been used to obtain samples to study the structure of human respiratory muscles and the expression of diverse substances in them. Samples are most often obtained from autopsies, from muscle biopsies during thoracotomy performed because of a localized pulmonary lesion (TLL), and from ambul...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Casadevall C,Coronell C,Minguella J,Blanco L,Orozco-Levi M,Barreiro E,Broquetas J,Gea J

    更新日期:2004-05-01 00:00:00

  • [Treatment of asthma with antileukotrienes and Churg-Strauss syndrome].

    abstract::Since antileukotriene treatment for asthma was introduced, there has been debate about whether such therapy can lead to Churg-Strauss Syndrome (CSS) or whether CSS is simply inhibited by the use of steroids, as various authors have suggested. We report a case in which we suspected CSS in a patient with bronchopulmonar...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Sala Félix J,Pereiro Alonso ME,Salas Antón C

    更新日期:2001-01-01 00:00:00

  • "Correct use of inhaled corticosteroids in chronic obstructive pulmonary disease": a consensus document.

    abstract:INTRODUCTION:Indications for inhaled corticosteroids (IC) in combination with long-acting bronchodilators (LABD) are well defined in clinical practice guidelines. However, there are some doubts about their efficacy and safety. The aim of this document is to establish an expert consensus to clarify these issues. METHOD...

    journal_title:Archivos de bronconeumologia

    pub_type: 共识发展会议,杂志文章,实务指引


    authors: Alcázar Navarrete B,Casanova C,Miravitlles M,de Lucas P,Riesco JA,Rodríguez González-Moro JM,Working Group “Consensus document on the appropriate use of inhaled corticosteroids in COPD”.

    更新日期:2015-04-01 00:00:00

  • Future biologic therapies in asthma.

    abstract::Despite the administration of appropriate treatment, a high number of patients with asthma remain uncontrolled. This suggests the need for alternative treatments that are effective, safe and selective for the established asthma phenotypes, especially in patients with uncontrolled severe asthma. The most promising opti...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Quirce S,Bobolea I,Domínguez-Ortega J,Barranco P

    更新日期:2014-08-01 00:00:00

  • [Pleural thickening in tuberculous pleural effusion. The associated factors].

    abstract::We aimed to determine which factors were related to the development of residual pleural thickening (RPT) after completion of prescribed treatment. Sixty-two patients with pleural tuberculosis (PTB) were assigned to 2 groups according to the presence or absence of RPT > 2 mm in the side and lower portion of a chest fil...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Soler JJ,Gil Suay V,Cordero P,Perpiñá M,Martínez E,Sanchis J

    更新日期:1995-04-01 00:00:00

  • [Early pleuropulmonary toxicity associated with cabergoline, an antiparkinsonian drug].

    abstract::We report a case of pleural effusion, pericardial thickening, and pulmonary involvement in a patient with dry cough, dyspnea, edema, and changes in the skin of the lower limbs. Treatment with cabergoline (Sogilen) had been started 4 months earlier. Pleural effusion, pericardial thickening, and impaired pulmonary funct...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Villavicencio C,Ramírez-Sarmiento A,Gayete A,Grau S,Orozco-Levi M

    更新日期:2007-09-01 00:00:00

  • Diagnosis of Tuberculous Infection in Immunosuppressed Patients and/or Candidates for Biologics Using a Combination of 2 IGRA Tests: T-SPOT.TB/QuantiFERON TB Gold In-Tube vs. T-SPOT.TB/QuantiFERON TB Gold Plus.

    abstract:INTRODUCTION:The diagnosis of latent tuberculous infection (LTI) by IGRA continues to generate debate. Experience in the simultaneous use of 2 IGRA tests is scant. The aim of this study was to compare the results of 2 versions of QuantiFERON-TB Gold (In-Tube/Plus) with those of T-SPOT.TB, and to analyse the effectivene...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Fernández-Blázquez A,Argüelles Menéndez P,Sabater-Cabrera C,García-García JM,Asensi Álvarez V,Palacios Gutiérrez JJ,en representación de la Red de Laboratorios de Microbiología del SESPA.

    更新日期:2020-06-10 00:00:00

  • [Use of blood products in patients treated surgically for stage I non-small cell lung cancer].

    abstract:OBJECTIVE:Retrospective study on the relation between the use of blood products and survival rates in patients treated surgically for stage I non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:The study included 856 patients who underwent surgical resection from 1969 to 2000 for stage I NSCLC, classified histolo...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Peñalver JC,Padilla J,Jordá C,Escrivá J,Cerón J,Calvo V,García A,Pastor J,Blasco E

    更新日期:2005-09-01 00:00:00

  • Myeloid-Derived Suppressor Cells: Possible Link Between Chronic Obstrucive Pulmonary Disease and Lung Cancer.

    abstract::Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are prevalent diseases and are a leading cause of morbidity and mortality worldwide. There is strong evidence to show that COPD is an independent risk factor for LC. Chronic inflammation plays a significant pathogenic role in COPD comorbidities, particu...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Scrimini S,Pons J,Sauleda J

    更新日期:2016-01-01 00:00:00