cDNA cloning, sequencing, and differential expression of a heart-type fatty acid-binding protein in the mummichog (Fundulus heteroclitus).

Abstract:

:A heart fatty acid-binding protein (H-FABP) cDNA was isolated from the liver of the mummichog (Fundulus heteroclitus) and the complete cDNA sequence and predicted amino acid sequence was determined. This cDNA binds to a mRNA product of 0.95 kb with the highest level of RNA expression in the male liver, gills, and gonads. Exposure of mummichogs to the polycyclic aromatic hydrocarbon (PAH) pyrene significantly down-regulated H-FABP expression at the highest concentration. This study provides evidence that environmentally relevant toxicants can modulate H-FABP expression.

journal_name

Mar Environ Res

authors

Bain LJ

doi

10.1016/s0141-1136(02)00130-7

keywords:

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

379-83

issue

3-5

eissn

0141-1136

issn

1879-0291

pii

S0141-1136(02)00130-7

journal_volume

54

pub_type

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