Abstract：
:The use of therapeutic moderate hypothermia for treating severe traumatic brain injury has been reported for more than 50 years. However, the most intense investigation of this treatment has occurred during the last 10 to 15 years. Virtually all preclinical studies have documented a robust treatment effect, not only in terms of reduced excitotoxicity and cerebral acidosis, but also in terms of histologic preservation and improved behavioral outcomes. Several single-center and small multicenter clinical trials conducted during the last decade also demonstrated benefit of early and late therapeutic hypothermia. However, a multicenter trial reported in February 2001 that included nearly 400 patients found no notable differences in neurologic outcomes in matched patients with head injuries who were treated with 48 hours of therapeutic moderate hypothermia compared with those kept at normal temperature. Findings from this study did suggest that rapid rewarming of patients with head injuries may be deleterious. A subgroup of young patients (less than 45 years of age) who were kept normovolemic showed a trend toward improved outcomes when treated with hypothermia. Current investigations, particularly in the preclinical arena, are focusing on combination therapy. To date, however, the addition of fibroblast growth factor, cyclosporine, or interleukin (IL)-10 to therapeutic moderate hypothermia has not been found to provide greater benefit than either therapy when used alone. Future investigations are aimed at further identifying the physiologic mechanisms responsible for secondary brain injury and ways in which other novel combination therapies may be expected to improve outcomes.
journal_name
Curr Opin Crit Carejournal_title
Current opinion in critical careauthors
Marion DWdoi
10.1097/00075198-200204000-00004keywords:
subject
Has Abstractpub_date
2002-04-01 00:00:00pages
111-4issue
2eissn
1070-5295issn
1531-7072journal_volume
8pub_type
杂志文章,评审abstract：PURPOSE OF REVIEW:Research and studies related to the long-term consequences of intensive care are increasing. This review focuses on some of the most recent knowledge in this field. RECENT FINDINGS:Still studies regarding the health-related quality of life (HRQOL) in survivors after intensive care are frequently publ...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0b013e32833cc90b
更新日期：2010-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Part II of this review gives an overview of the different maternal cardiac problems during pregnancy and their management, and developments over recent years. RECENT FINDINGS:Many studies published over the last 5 years provided new insights on different cardiac diseases in pregnancy. Publications di...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/01.ccx.0000179806.15328.b9
更新日期：2005-10-01 00:00:00
abstract：PURPOSE OF REVIEW:The ultimate goal of cardiopulmonary resuscitation is long-term neurologically intact survival. Despite numerous well-designed studies, the medications currently used in advanced cardiac life support have not demonstrated success in this regard. This review describes the novel therapeutics under inves...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0b013e328364d7b1
更新日期：2013-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Traumatic injury continues to be a significant cause of morbidity and mortality in the year 2011. In addition, the healthcare expenditures and lost years of productivity represent significant economic cost to the affected individuals and their communities. Helicopters have been used to transport traum...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0b013e32834c5655
更新日期：2011-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Modern technologies allow visualization of microcirculatory disorders. This review describes how the coagulatory inhibitors antithrombin and activated protein C (APC) can improve microcirculation in sepsis and transplantation. RECENT FINDINGS:The effects of antithrombin and APC on microcirculatory di...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/01.ccx.0000244121.54495.f7
更新日期：2006-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Acute kidney injury (AKI) is a frequent and serious event associated with a high rate of complications, with an increased risk of progression to multiple organ dysfunction and excessive 'attributable' mortality. AKI affects all physiologic functions and organ systems with interrelated mechanisms, incl...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0000000000000150
更新日期：2014-12-01 00:00:00
abstract：PURPOSE OF REVIEW:The pulmonary artery catheter is one of the most scrutinized monitors used in intensive care today. Pulmonary artery catheter use is declining due to limited demonstrated beneficial outcomes and the advancement of less invasive monitoring. This study discusses the current use of the pulmonary artery c...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0b013e32832b302b
更新日期：2009-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Progress has been made in our understanding of gut dysfunction in critical illness. This review will outline new findings and give perspectives based on previous knowledge and concurrent advances in nutrition. RECENT FINDINGS:The relationship between gut dysfunction and poor outcomes in critical illn...
journal_title：Current opinion in critical care
pub_type： 杂志文章
doi：10.1097/MCC.0000000000000813
更新日期：2021-01-21 00:00:00
abstract：PURPOSE OF REVIEW:Acute coagulopathy of trauma has only been described relatively recently. Developing early in the postinjury phase, it is associated with increased transfusion requirements and poor outcomes. This review examines the possible initiators, mechanism and clinical importance of acute coagulopathy. RECENT...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0b013e3282f1e78f
更新日期：2007-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Although conventional anticonvulsant agents can terminate status epilepticus in most cases, a substantial minority of patients develops medically refractory status and requires more aggressive care. This review explores the options available. RECENT FINDINGS:Increasing numbers of previously unexpecte...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/01.ccx.0000157079.72999.87
更新日期：2005-04-01 00:00:00
abstract：PURPOSE OF REVIEW:To provide an update on the progress of the multicenter, randomized, controlled trial of corticosteroids after significant head injury (CRASH). RECENT FINDINGS:After a successful pilot phase, the main phase of the CRASH Trial began in March 2001. By June 2002, 107 hospitals from 31 countries were par...
journal_title：Current opinion in critical care
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1097/00075198-200304000-00003
更新日期：2003-04-01 00:00:00
abstract：PURPOSE OF REVIEW:This article reviews current concepts in perioperative pulmonary management. RECENT FINDINGS:Preoperative risk assessment tools for perioperative pulmonary complications (POPCs) are evolving for both children and adults. Intraoperative management strategies have a demonstrable effect on outcomes. Lat...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0b013e328348bfc8
更新日期：2011-08-01 00:00:00
abstract：PURPOSE OF REVIEW:With the publication of the results of the recent CORTICUS trial, stress ('low') doses of corticosteroids for the treatment of vasopressor-dependent septic shock in adults can still be considered controversial. The purpose of this narrative review is to elaborate the pros and cons of this treatment in...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0b013e328306a01d
更新日期：2008-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Mechanical ventilation is a cornerstone of ICU treatment. Because of its interaction with blood flow and intra-abdominal pressure, mechanical ventilation has the potential to alter hepato-splanchnic perfusion, abdominal organ function and thereby outcome of the most critically ill patients. RECENT FI...
journal_title：Current opinion in critical care
pub_type： 杂志文章
doi：10.1097/MCC.0b013e3283374b1c
更新日期：2010-04-01 00:00:00
abstract：:Widespread provision of early defibrillation following cardiac arrest holds major promise for improved survival from ventricular fibrillation. The critical element in predicting a successful outcome is the rapidity with which defibrillation is achieved. A worldwide awareness of this potential and its advocacy by such ...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/00075198-200106000-00002
更新日期：2001-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Securing the airway to provide sufficient oxygenation and ventilation is of paramount importance in the management of all types of emergency patients. Particularly in severely injured patients, strategies should be adapted according to useful recent literature findings. RECENT FINDINGS:The role of ou...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0000000000000160
更新日期：2014-12-01 00:00:00
abstract：PURPOSE OF REVIEW:To describe current antimicrobial resistance in ESKAPE Gram-negative microorganisms and their situation in the ICUs, the implication of the so-called high-risk clones (HiRCs) involved in the spread of antimicrobial resistance as well as relevance of the COVID-19 pandemic in the potential increase of r...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0000000000000755
更新日期：2020-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Multiple factors influence the dependability of intensive care provision. The management of a group of unstable, critically ill patients requires focused attention from the clinical team. Medical simulation is an important tool to improve safety and team work within the ICU. RECENT FINDINGS:The criti...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0b013e3282f1bb32
更新日期：2007-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Early prognostication in acute brain damage remains a challenge in the realm of critical care. There remains controversy over the most optimal methods that can be utilized to predict outcome. The utility of recently reported prognostic biomarkers and clinical methods will be reviewed. RECENT FINDINGS...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0b013e32835eba56
更新日期：2013-04-01 00:00:00
abstract：PURPOSE OF REVIEW:Ventilator-induced lung injury (VILI) can occur despite use of tidal volume (VT) limited to 6 ml/kg of predicted body weight, especially in patients with a smaller aerated compartment (i.e. the baby lung) in which, indeed, tidal ventilation takes place. Because respiratory system static compliance (CR...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0000000000000377
更新日期：2017-02-01 00:00:00
abstract：PURPOSE OF REVIEW:The comparison of morbidity, mortality, and length-of-stay outcomes in patients receiving critical care requires adjustment based on their presenting illness. These adjustments are made with severity-of-illness models. These models must be periodically updated to reflect current medical practices. Thi...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0b013e3283101643
更新日期：2008-10-01 00:00:00
abstract：PURPOSE OF REVIEW:The risk of adverse outcome in patients undergoing major surgery is affected both by cardiorespiratory fitness, and the presence and severity of comorbidities. Accurate risk stratification is essential for the identification of patients who may benefit from specific perioperative management strategies...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0b013e32832e067c
更新日期：2009-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Cardiac arrest is one of the most challenging disease processes to study with clinical trials due to the emergent and unpredictable nature of these events and complexity of the patient population. In recent years, there has been a major push to complete more large, multicentre trials. In many cases, h...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0000000000000765
更新日期：2020-12-01 00:00:00
abstract：PURPOSE OF REVIEW:To summarize clinical evidence for intraoperative ventilation settings, which could protect against postoperative pulmonary complications (PPCs) in surgical patients with uninjured lungs. RECENT FINDINGS:There is convincing evidence for protection against PPCs by low tidal volumes: benefit was found ...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0000000000000215
更新日期：2015-08-01 00:00:00
abstract：PURPOSE OF REVIEW:This review summarizes current understanding of the pathophysiology of cardiogenic pulmonary edema, its causes and treatment. RECENT FINDINGS:The pathobiology and classification of pulmonary edema is more complex than the hydrostatic vs. permeability dichotomy of the past. Mechanisms of alveolar flui...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0000000000000626
更新日期：2019-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Delirium is frequently encountered in the ICU and is associated with significant adverse outcomes. The increasingly recognized consequences of ICU delirium should enhance efforts to improve recognition and management of this serious problem. We aim to review the recent literature on ICU delirium, incl...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0b013e32835132b9
更新日期：2012-04-01 00:00:00
abstract：PURPOSE OF REVIEW:To describe the current knowledge about clinical and microbiological diagnosis of nonventilated hospital-acquired pneumonia (NV-HAP). RECENT FINDINGS:NV-HAP is emerging as a new challenge for clinicians, particularly because VAP incidence has been decreasing. The clinical diagnosis of NV-HAP uses the...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0000000000000525
更新日期：2018-10-01 00:00:00
abstract：PURPOSE OF REVIEW:To discuss the perioperative monitoring tools and targets for haemodynamic optimization and to assess the influence of goal-directed therapy (GDT) on organ function, complications and outcome in different categories of surgical patients. RECENT FINDINGS:The choice of perioperative haemodynamic monito...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0b013e32833ab81e
更新日期：2010-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Efforts to improve outcomes from acute kidney injury (AKI) have focussed on timely diagnosis and effective delivery of basic patient care. Electronic alerts (e-alerts) for AKI have attracted interest as a tool to facilitate this. Initial feasibility has already been demonstrated; this review will disc...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/MCC.0000000000000245
更新日期：2015-12-01 00:00:00
abstract：:Intra-abdominal infection continues to pose a significant threat to critically ill patients in the year 2000. A review of the current literature reveals that despite remarkable developments in critical care medicine and extensive study of patients with tertiary peritonitis, the associated mortality rate remains nearly...
journal_title：Current opinion in critical care
pub_type： 杂志文章,评审
doi：10.1097/00075198-200104000-00010
更新日期：2001-04-01 00:00:00
