Abstract:
:Understanding the gene-expression patterns during liver regeneration may help to reveal how regenerative processes are initiated and controlled as well as shed new light onto processes that lead to liver disease. Using high-density oligonucleotide arrays, we have examined the gene-expression program in the livers of mice after partial hepatectomy. A time course was constructed for gene expression between 0 and 4 h after partial hepatectomy, corresponding to the priming phase of liver regeneration. The genomic program for liver regeneration involves transcription-factor generation, stress and inflammatory responses, cytoskeletal and extracellular matrix modification, and regulation of cell-cycle entry. The genome-wide changes that are observed provide a detailed and comprehensive map of the initial priming stage of liver regeneration.
journal_name
Proc Natl Acad Sci U S Aauthors
Su AI,Guidotti LG,Pezacki JP,Chisari FV,Schultz PGdoi
10.1073/pnas.122359899keywords:
subject
Has Abstractpub_date
2002-08-20 00:00:00pages
11181-6issue
17eissn
0027-8424issn
1091-6490pii
122359899journal_volume
99pub_type
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