Reducing agent dithiothreitol facilitates activity of the capsaicin receptor VR-1.

abstract：:Imaging genetics has emerged as a powerful and sensitive approach to the study of functional genetic variations and brain responses in psychiatric and neurologic disorders. Ethics issues in contemporary neuroscience as they apply separately to genetics and neuroimaging have been a growing focus for research but, to da...

journal_title：Neuroscience

authors： Tairyan K,Illes J

更新日期：2009-11-24 00:00:00

abstract：:The regional distribution of the specific D1 agonist [3H]SKF 38393 (SKF 38393, 2,3,4,5-tetra-hydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine) has been studied autoradiographically in the rat CNS. The binding of [3H]SKF 38393 to striatal sections was saturable, stereospecific, reversible, of high affinity (Kd = 9.9 nM) a...

journal_title：Neuroscience

authors： Dubois A,Savasta M,Curet O,Scatton B

更新日期：1986-09-01 00:00:00

abstract：:Ocular dominance has been extensively studied, often with the goal to understand neuroplasticity, which is a key characteristic within the critical period. Recent work on monocular deprivation, however, demonstrates residual neuroplasticity in the adult visual cortex. After deprivation of patterned inputs by monocular...

journal_title：Neuroscience

authors： Bai J,Dong X,He S,Bao M

更新日期：2017-06-03 00:00:00

abstract：:It is well known that the electroencephalogram of the cat in the early stages of slow wave sleep is mainly characterized by rhythmic wave activity at 7-14 Hz, termed spindles, which recur periodically with a slow rhythm of 0.1-0.2 Hz. From early stimulation, decortication and transection studies (see Ref. 14), spindle...

journal_title：Neuroscience

authors： Marini G,Macchi G,Mancia M

更新日期：1992-12-01 00:00:00

abstract：:Amyloid-β (Aβ) production and clearance in the brain is a crucial focus of investigations into the pathogenesis of Alzheimer disease. Imbalance between production and clearance leads to accumulation of Aβ. The important Aβ-degrading enzymes in the brain are neprilysin (NEP) and insulin-degrading enzyme (IDE), and defe...

journal_title：Neuroscience

authors： Yamamoto N,Shibata M,Ishikuro R,Tanida M,Taniguchi Y,Ikeda-Matsuo Y,Sobue K

更新日期：2017-10-24 00:00:00

abstract：:Interleukin-1 (IL-1) plays a crucial role in stress responses and its mRNA is induced in the brain by stress load; however, the precise role of IL-1 in higher brain functions and their abnormalities is largely unknown. Here, we report that IL-1 receptor antagonist (IL-1Ra) knockout (KO) mice, which lack IL-1Ra molecul...

journal_title：Neuroscience

authors： Wakabayashi C,Kiyama Y,Kunugi H,Manabe T,Iwakura Y

更新日期：2011-09-29 00:00:00

abstract：:Although intrathecal administration of nociceptin, an endogenous ligand of the opioid receptor-like1 receptor, exhibits an antinociceptive effect in various pain models, cellular mechanisms underlying this action are still unknown. Here, we investigated the effects of nociceptin on excitatory and inhibitory synaptic t...

journal_title：Neuroscience

authors： Luo C,Kumamoto E,Furue H,Chen J,Yoshimura M

更新日期：2002-01-01 00:00:00

abstract：:A new mammalian neuromuscular preparation is introduced for physiology and microscopy of all sorts: the intrinsic muscle of the mouse ear. The great utility of this preparation is demonstrated by illustrating how it has permitted us to develop a wholly new technique for staining muscle T-tubules, the critical conducti...

journal_title：Neuroscience

authors： Heuser JE,Tenkova TI

更新日期：2020-07-15 00:00:00

abstract：:Apoptosis, or programmed cell death, resulting from cerebral ischemia may be related to decreased levels of anti-apoptotic factors, such as serine/threonine kinase (Akt), phosphorylated Akt (pAkt), pBAD, and Bcl-2, and increased levels of pro-apoptotic factors, such as BAD, caspase 9, and caspase 3 activities. In this...

journal_title：Neuroscience

authors： Yip KK,Lo SC,Leung MC,So KF,Tang CY,Poon DM

更新日期：2011-09-08 00:00:00

abstract：:Exercise has been shown to impact brain plasticity and function by involving the action of brain-derived neurotrophic factor (BDNF); however, mechanisms involved are poorly understood. Two types of BDNF coexist in the brain, the precursor (proBDNF) and its mature product (mBDNF), which preferentially bind specific rec...

journal_title：Neuroscience

authors： Ding Q,Ying Z,Gómez-Pinilla F

更新日期：2011-09-29 00:00:00

abstract：:The role of agrin in synaptogenesis has been extensively studied. On the other hand, little is known about the function of this extracellular matrix protein during developmental processes that precede the formation of synapses. Recently, agrin was shown to regulate the rate of neurite elongation and the behavior of gr...

journal_title：Neuroscience

authors： Bergstrom RA,Sinjoanu RC,Ferreira A

更新日期：2007-11-09 00:00:00

abstract：:The pontine projection of the flocculus and adjacent ventral paraflocculus was investigated with antegrade and retrograde axonal tracer techniques. Injections of horseradish peroxidase into the floccular complex revealed subsets of labeled neurons in the nucleus reticularis tegmenti pontis, the nucleus raphe pontis an...

journal_title：Neuroscience

authors： Gerrits NM,Epema AH,Voogd J

更新日期：1984-03-01 00:00:00

abstract：:The hippocampus plays an important role in central stress integration. The present study tests the hypothesis that the ventral subiculum, as a principal source of hippocampal efferents, is involved in co-ordination of hypothalamo-pituitary-adrenocortical and behavioural responses to cognitively-processed information. ...

journal_title：Neuroscience

authors： Herman JP,Dolgas CM,Carlson SL

更新日期：1998-09-01 00:00:00

abstract：:Acetylcholine (ACh) plays important roles in the modulation of activity and plasticity of primary sensory cortices, thus influencing sensory detection and integration. We examined this in urethane-anesthetized rats, comparing cholinergic modulation of short latency, large amplitude field postsynaptic potentials (fPSPs...

journal_title：Neuroscience

authors： Kuo MC,Rasmusson DD,Dringenberg HC

更新日期：2009-09-29 00:00:00

abstract：:Intermittent hypoxia induces 5-HT-dependent, pattern-sensitive long-term facilitation (LTF) of spinal respiratory motor output. We used a split-bath in vitro neonatal rat brainstem-spinal cord preparation to test whether: 1) intermittent spinal 5-HT exposure (without hypoxia) is sufficient to induce LTF in phrenic and...

journal_title：Neuroscience

authors： Lovett-Barr MR,Mitchell GS,Satriotomo I,Johnson SM

更新日期：2006-10-27 00:00:00

abstract：:Hippocampal cell firing in awake, behaving rats is often spatially selective, and such cells have been called place cells. Similar spatial correlates have also been described for neurons in the medial entorhinal and perirhinal cortices. All three regions receive sensory associational input from postrhinal cortex, whic...

journal_title：Neuroscience

authors： Burwell RD,Hafeman DM

更新日期：2003-01-01 00:00:00

abstract：:The fact that neurobiological research is reliant upon laboratory-reared rodents is well known. The following paper discusses this topic broadly, but also aims to highlight other species used in the study of the nervous system and the evolution of animal species usage from the end of World War II through recent invest...

journal_title：Neuroscience

authors： Żakowski W

更新日期：2020-05-01 00:00:00

abstract：:Spinules found in brain consist of small invaginations of plasma membranes which enclose membrane evaginations from adjacent cells. Here, we focus on the dynamic properties of the most common type, synaptic spinules, which reside in synaptic terminals. In order to test whether depolarization triggers synaptic spinule ...

journal_title：Neuroscience

authors： Tao-Cheng JH,Dosemeci A,Gallant PE,Miller S,Galbraith JA,Winters CA,Azzam R,Reese TS

更新日期：2009-04-21 00:00:00

abstract：:Cell surface glycoconjugates are thought to mediate cell-cell recognition and play roles in neuronal development and functions. We demonstrated here that exposure of neuronal cells to nanomolar levels of gangliosides Neu5Acalpha 8Neu5Acalpha 3Galbeta 4GlcCer, Galbeta 3GalNAcbeta 4(Neu5Acalpha 8Neu5Acalpha 3)Galbeta 4G...

journal_title：Neuroscience

authors： Chen N,Furuya S,Doi H,Hashimoto Y,Kudo Y,Higashi H

更新日期：2003-01-01 00:00:00

abstract：:The peripheral reorganization of pulpal nerves after tooth injury was studied, in the rat, with anterograde horseradish peroxidase tracing techniques, and combined retrograde Fluorogold tracing and immunohistochemistry was employed to examine the effects of inferior alveolar nerve lesions or tooth injury on some cytoc...

journal_title：Neuroscience

authors： Fried K,Arvidsson J,Robertson B,Pfaller K

更新日期：1991-01-01 00:00:00

abstract：:The peripheral sympathetic and parasympathetic cholinergic innervation was investigated with antibodies directed against the C-terminus of the rat vesicular acetylcholine transporter. Immunohistochemistry for the vesicular acetylcholine transporter resulted in considerably more detailed visualization of cholinergic te...

journal_title：Neuroscience

authors： Schäfer MK,Eiden LE,Weihe E

更新日期：1998-05-01 00:00:00

abstract：:Diversity in social structures, from solitary to eusocial, is a prominent feature of subterranean African mole-rat species. Damaraland mole-rats are eusocial, they live in colonies that are characterized by a reproductive division of labor and a subdivision into castes based on physiology and behavior. Damaraland mole...

journal_title：Neuroscience

authors： Oosthuizen MK,Amrein I

更新日期：2016-06-02 00:00:00

abstract：:Activation of muscarinic receptors leads to proliferation of astroglial cells and this effect is inhibited by ethanol. Among the intracellular pathways involved in the mitogenic action of muscarinic agonists, activation of the atypical protein kinase C zeta (PKC zeta) appears to be of most importance, and is also affe...

journal_title：Neuroscience

authors： Guizzetti M,Bordi F,Dieguez-Acuña FJ,Vitalone A,Madia F,Woods JS,Costa LG

更新日期：2003-01-01 00:00:00

abstract：:Cognitive flexibility, the ability to adjust behavior in response to new and unexpected conditions in the environment, is essential for adaptation to new challenges and survival. The cholinergic system is an important modulator of this complex behavior however, the exact cholinergic circuits involved in this modulatio...

journal_title：Neuroscience

authors： Prado VF,Janickova H,Al-Onaizi MA,Prado MA

更新日期：2017-03-14 00:00:00

abstract：:The motor output of hypoglossal motoneurons to tongue muscles takes place in concert with the respiratory rhythm and is determined by the balance between excitatory glutamatergic transmission and inhibitory transmission mediated by glycine or GABA. The relative contribution by these transmitters is a phasic phenomenon...

journal_title：Neuroscience

authors： Pagnotta SE,Lape R,Quitadamo C,Nistri A

更新日期：2005-01-01 00:00:00

abstract：:Strong converging evidence indicates that the intermediate and medial part of the hyperstriatum ventrale (IMHV) of the chick forebrain is a site of recognition memory for the learning process of imprinting. Clathrin proteins have been implicated in synaptic plasticity. In the present study we demonstrate for the first...

journal_title：Neuroscience

authors： Solomonia RO,McCabe BJ,Jackson AP,Horn G

更新日期：1997-09-01 00:00:00

abstract：:In the human thalamic ventralis lateralis nucleus the spontaneous activity of 235 single units during 38 stereotactic operations in locally anaesthetized parkinsonian patients was analysed. Two basic cell types (A and B) were shown to exist in this nucleus: (i) with unitary irregular (2-40/s) discharges characterized ...

journal_title：Neuroscience

authors： Raeva S,Vainberg N,Dubinin V

更新日期：1999-01-01 00:00:00

abstract：:Nicotinic stimulation and high K+ depolarization of bovine chromaffin cells cause disassembly of cortical filamentous actin networks. Previous work from our laboratory has demonstrated that disassembly of actin filaments is Ca(2+)-dependent, precedes exocytosis and occurs in cortical areas of low cytoplasmic viscosity...

journal_title：Neuroscience

authors： Vitale ML,Rodríguez Del Castillo A,Trifaró JM

更新日期：1992-11-01 00:00:00

abstract：:Experiments in a variety of preparations have indicated that excessive activation of receptors for the excitatory amino acids glutamate and aspartate may mediate irreversible anoxic neuronal injury. We investigated this hypothesis in the in vitro hippocampal slice. Rat hippocampal slices perfused for 40 min with buffe...

journal_title：Neuroscience

authors： Clark GD,Rothman SM

更新日期：1987-06-01 00:00:00

abstract：:Significant alterations in glutamatergic neurotransmission have been reported in major depressive disorder (MDD) that could underlie psychiatric traits. Studies were mainly interested in synaptic dysfunction in the prefrontal cortex, a key structure involved in depressive-like behavior, however hippocampus has been sh...

journal_title：Neuroscience

authors： Dutar P,Tolle V,Kervern M,Carcenac C,Carola V,Gross C,Savasta M,Darmon M,Masson J

更新日期：2019-01-01 00:00:00