Cyclic GMP signaling in podocytes.


:Natriuretic peptides (NP), together with nitric oxide (NO) are powerful relaxing factors acting via a common second messenger, cyclic GMP (cGMP). Together with other vasoactive modulators, these vasorelaxing factors play an essential role in regulating the function of kidney glomeruli. The presence of NP receptors in podocytes has been well documented. Recently, also mRNA for soluble guanylate cyclase, the NO receptor, has been shown in these cells. Stimulation of podocytes with atrial natriuretic peptide (ANP), C-type natriuretic peptide (CNP), and NO donors results in considerable upregulation of cellular cGMP synthesis. The podocyte foot processes contain a highly organized network of microfilaments adhering to the glomerular basement membrane (GBM). Changes in podocyte cytoskeleton accompanied by detachment of the cells from the GBM are closely associated with many glomerulopathies. The contractile apparatus in the podocyte foot processes seems to be an obvious target for the cyclic GMP signaling cascade. However, little is known about implications of the cGMP synthesis in these cells. We briefly review the current art regarding generation and modulation of cyclic GMP levels in podocytes. We discuss also the possible targets for this secondary messenger as well as its functional role in podocytes.


Microsc Res Tech


Lewko B,Stepinski J





Has Abstract


2002-05-15 00:00:00












  • The transformation of phytolith morphology as the result of their exposure to high temperature.

    abstract::Phytoliths are an important component for interpreting the ancient botanical record. However, phytoliths can be altered through heating, either as the result of such activities as firing ceramics, clay molds use for casting metal or in hearths. Phytoliths can also be altered through heating as the result of creating c...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: Wu Y,Wang C,Hill DV

    更新日期:2012-07-01 00:00:00

  • Research on the drag reduction property of puffer (Takifugu flavidus) spinal nonsmooth structure surface.

    abstract::Puffers show good drag reduction performance during migration. It is worth noting that spines which are different from ordinary fish scales are densely distributed on the puffer skin. Here, the special morphological structure of puffer spines was observed using microscopy techniques, accurate contour models were estab...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: Zhou H,Liu C,Tian G,Feng X,Jia C

    更新日期:2020-07-01 00:00:00

  • Effect of age on the structure of Meissner corpuscles in murine digital pads.

    abstract::A light and electron microscopic study was performed to determine age changes in Meissner corpuscles. In forepaw digital pads of mice aged to their maximum life expectancy, corpuscles were found to increase in size and complexity until middle age, and then to become smaller, disorganized and lobulated with more advanc...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: Nava PB,Mathewson RC

    更新日期:1996-07-01 00:00:00

  • Laser-based in situ techniques: novel methods for generating extreme conditions in TEM samples.

    abstract::The dynamic transmission electron microscope (DTEM) is introduced as a novel tool for in situ processing of materials. Examples of various types of dynamic studies outline the advantages and differences of laser-based heating in the DTEM in comparison to conventional (resistive) heating in situ TEM methods. We demonst...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: Taheri ML,Lagrange T,Reed BW,Armstrong MR,Campbell GH,DeHope WJ,Kim JS,King WE,Masiel DJ,Browning ND

    更新日期:2009-03-01 00:00:00

  • Description of the immatures of workers of the ant Linepithema micans Forel (Hymenoptera: Formicidae).

    abstract::Linepithema micans Forel is a poorly studied species that is now considered a pest in vineyards in South Brazil. Larval characters have been used in a few phylogenetic studies, and their importance greatly depends in the amount of available information on different species. This study presents a complete panorama on t...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: Nondillo A,Solis DR,Fox EG,Rossi ML,Botton M,Bueno OC

    更新日期:2011-04-01 00:00:00

  • Confocal microscopy of thick sections from acrylamide gel embedded embryos.

    abstract::The preparation of optically clear, thick sections of fragile embryonic tissues greatly aids the power of confocal scanning laser microscopy in imaging three-dimensional structures. We report here conditions for embedding, sectioning, and staining embryos in polyacrylamide gels for a variety of confocal imaging techni...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: Germroth PG,Gourdie RG,Thompson RP

    更新日期:1995-04-15 00:00:00

  • Development of histamine-immunoreactivity in the Central nervous system of the two locust species Schistocerca gregaria and Locusta migratoria.

    abstract::Locusts are attractive model preparations for cellular investigations of neurodevelopment. In this study, we investigate the immunocytochemical localization of histamine in the developing ventral nerve cord of two locust species, Schistocerca gregaria and Locusta migratoria. Histamine is the fast neurotransmitter of p...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: Pätschke A,Bicker G

    更新日期:2011-10-01 00:00:00

  • Micromorphology, pharmacognosy, and bio-elemental analysis of an important medicinal herb: Verbascum thapsus L.

    abstract::The present study was conducted on characterization of morpho-anatomical, phytochemical, and bio-elemental analysis of root, stem, and leaf of Verbascum thapsus. Morphologically Verbascum is a biennial plant that flowers for a month and a half in mid- to late summer. Various organoleptic features of root, leaf, and st...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: Khan SA,Dastagir G,Uza NU,Muhammad A,Ullah R

    更新日期:2020-06-01 00:00:00

  • Laminins and their roles in mammals.

    abstract::Laminins are alpha-beta-gamma heterotrimeric components of all basement membranes. Laminins are now known to play the central role in organizing and establishing the basement membrane. The diversity of laminins allows them to impart special structural and signaling properties to the basement membrane. Of the 12 known ...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章,评审


    authors: Miner JH

    更新日期:2008-05-01 00:00:00

  • Depletion of enteroendocrine and mucus-secreting cells is associated with colorectal carcinogenesis severity and impaired intestinal motility in rats.

    abstract::This study investigated the relationship between enteroendocrine and mucus-secreting cells distribution, the severity of colonic mucosal injury and intestinal motility in experimental colorectal carcinogenesis. Using a standardized murine model of colorectal carcinogenesis, eight-weeks-old female Wistar rats weighting...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: Novaes RD,Sequetto PL,Vilela Gonçalves R,Cupertino MC,Santos EC,Mello VJ,Araújo MR,Silva E,Oliveira TT

    更新日期:2016-01-01 00:00:00

  • Immunohistochemical localization of epidermal growth factor system in the lung of the Japanese quail (Coturnix coturnix japonica) during the post-hatching period.

    abstract::The purpose of this study is to determine the possible changes in the localization of the four Epidermal Growth Factor Receptors and three ligands in quail lungs from the first day of hatching until the 125th after hatching using immunohistochemical methods. Immunohistochemical results demonstrated that four EGFRs and...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: Alan E,Lİman N,Sağsöz H

    更新日期:2015-09-01 00:00:00

  • The microcomputer and image analysis in diagnostic pathology.

    abstract::This paper presents a snapshot view of the influence and direction of microcomputer technology for image analysis techniques in diagnostic pathology. Microcomputers have had considerable impact in bringing image analysis to wider application. Semi-automated tracing techniques are a simple means of providing objective ...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章,评审


    authors: Jarvis LR

    更新日期:1992-06-01 00:00:00

  • Action of andiroba oil (Carapa guianensis) on Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae) semi-engorged females: morphophysiological evaluation of reproductive system.

    abstract::Because of the increasing medical-veterinary importance of ticks, the development of alternative control methods, less aggressive to the host and the environment has become the target of several researches. In this sense, the present study analyzed the action of different concentrations (5, 10, and 20%) of andiroba se...

    journal_title:Microscopy research and technique

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    authors: Vendramini MC,Mathias MI,De Faria AU,Furquim KC,De Souza LP,Bechara GH,Roma GC

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  • Imaging of three-dimensional epithelial architecture and function in cultured CaCo2a monolayers with two-photon excitation microscopy.

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    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: Gilbert RJ,Hoffman M,Capitano A,So PT

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  • Effects of vitamin A deficiency on the inter-Sertoli cell tight junctions and on the germ cell population.

    abstract::When 20-day-old rats are placed on a vitamin A deficient diet (VAD) for a period of 10 weeks, the seminiferous tubules are found to contain only Sertoli cells, a few residual A0, A1 spermatogonia, and preleptotene spermatocytes (PL). The type A1 spermatogonia and PL spermatocytes are arrested in their G2 phase. In VAD...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: Ismail N,Morales CR

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  • Effect of ultrasonic excitation on the porosity of glass ionomer cement: a scanning electron microscope evaluation.

    abstract:BACKGROUND:Ultrasonic excitation (US) was applied to glass ionomer cement (GIC) during early set time to increase the advantageous properties of this material. PURPOSE:The aim of this in vitro study was to assess the inner porosity of GIC after US. STUDY DESIGN:A total of 16 specimens, for each material, were prepare...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: Coldebella CR,Santos-Pinto L,Zuanon AC

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  • In vivo second-harmonic generation and ex vivo coherent anti-stokes raman scattering microscopy to study the effect of obesity to fibroblast cell function using an Yb-fiber laser-based CARS extension unit.

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    pub_type: 杂志文章


    authors: Haluszka D,Lőrincz K,Molnár G,Tamás G,Kolonics A,Szipőcs R,Kárpáti S,Wikonkál NM

    更新日期:2015-09-01 00:00:00

  • Measurement of edge verticality of optical recording bits on blu-ray discs using scanning probe microscopy.

    abstract::This work investigates recording bits on recordable and rewritable blu-ray discs using atomic force microscopy and conducting atomic force microscopy with high contrast, respectively. The geometric structure of the recording bits is clearly observed in images, which, when coupled with cross-section analysis, yields pr...

    journal_title:Microscopy research and technique

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    authors: Chen SH,Lin WS,Wang WC

    更新日期:2010-01-01 00:00:00

  • Comparison between two different methods for evaluating rumen papillae measures related to different diets.

    abstract::Although the Geographical Information System (GIS), which integrates computerized drawing computer assisted design (CAD) and relational databases (data base management system (DBMS)), is best known for applications in geographical and planning cartography, it can also use many kinds of information concerning the terri...

    journal_title:Microscopy research and technique

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    authors: Scocco P,Brusaferro A,Catorci A

    更新日期:2012-07-01 00:00:00

  • Distribution of the catecholaminergic neurons in the central nervous system of human embryos and fetuses.

    abstract::The catecholaminergic cell groups in the human brain, denominated from A1 to A17, display some striking anatomical differences with those described in the rodent. These differences are essentially observed in the extent of the dopaminergic neurons and especially their axonal fields in the telencephalon. Immunocytochem...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: Verney C

    更新日期:1999-07-01 00:00:00

  • Comparative B-mode and Doppler renal ultrasonography with histopathological findings in dogs positive for canine visceral leishmaniasis.

    abstract::Morphological parameters and renal flow were assessed and measured in six clinically healthy dogs with negative serological and parasitological examinations for canine visceral leishmaniasis (CVL) and six dogs with CVL-positive serological and parasitological tests and asymptomatic condition of the disease. Kidney len...

    journal_title:Microscopy research and technique

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    authors: Baltazar PI,Da Silva Moura L,Pessoa GT,De Sá Rodrigues RP,Sanches MP,Das Neves Diniz A,Das Chagas Araújo Sousa F,Guerra PC,Neves WC,Giglio RF,De Jesus Rosa Pereira Alves J,De Assis Leite Souza F,Braga JF,Alves FR

    更新日期:2016-07-01 00:00:00

  • Organ culture of the bovine subcommissural organ: evidence for synthesis and release of the secretory material.

    abstract::The subcommissural organ (SCO) is a brain circumventricular organ formed by ependymal and hypendymal secretory cells. It secretes glycoproteins into the cerebrospinal fluid of the third ventricle where they condense into a thread-like structure known as Reissner's fiber (RF). The present study was designed to investig...

    journal_title:Microscopy research and technique

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    authors: Schöbitz K,Gonzalez C,Peruzzo B,Yulis CR,Rodríguez EM

    更新日期:2001-03-01 00:00:00

  • From oogonia to mature oocytes: inactivation of the maternal centrosome in humans.

    abstract::The fine structure of human oogonia and growing oocytes has been reviewed in fetal and adult ovaries. Preovulatory maturation and the ultrastructure of stimulated oocytes from the germinal vesicle (GV) stage to metaphase II (MII) stage are also documented. Oogonia have large nuclei, scanty cytoplasm with complex mitoc...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章,评审


    authors: Sathananthan AH,Selvaraj K,Girijashankar ML,Ganesh V,Selvaraj P,Trounson AO

    更新日期:2006-06-01 00:00:00

  • Effects of aerobic training, resistance training, or combined resistance-aerobic training on the left ventricular myocardium in a rat model.

    abstract::This study follows the left ventricular (LV) hypertrophy in rats undergoing aerobic training alone (A), resistance training alone (R), or combined resistance and aerobic training (RA) (usually referred as concurrent training) program. A sedentary control group (C) was included. LV remodeling was evaluated using electr...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: De Souza MR,Pimenta L,Pithon-Curi TC,Bucci M,Fontinele RG,De Souza RR

    更新日期:2014-09-01 00:00:00

  • Dissociation of memory retrieval and search processes: an event-related fMRI study.

    abstract::A cognitive task can often be subdivided into several subprocesses, which follow a specific temporal order. Here, we report an event-related functional magnetic resonance imaging (fMRI) experiment on memory search, in which the temporal onset of search in primary memory was varied relative to retrieval from secondary ...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: Pollmann S,Zysset S,Wiggins CJ,Von Cramon DY

    更新日期:2000-10-01 00:00:00

  • Synaptic prion protein immuno-reactivity in the rodent cerebellum.

    abstract::The cellular prion protein PrP(c) is a neurolemmal glycoprotein essential for the development of the transmissible spongiform encephalopathies. In these neurodegenerative diseases, host PrP(c) is converted to infectious protease-resistant isoforms PrP(res) or prions. Prions provoque predictable and distinctive pattern...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: Haeberlé AM,Ribaut-Barassin C,Bombarde G,Mariani J,Hunsmann G,Grassi J,Bailly Y

    更新日期:2000-07-01 00:00:00

  • Cell and matrix morpho-functional analysis in chondrocyte micromasses.

    abstract::Micromass cultures represent a convenient means of studying chondrocyte physiology in the context of a tridimensional culture model. In this study, we present the first ultrastructural analysis of the distribution and organization of the extracellular components in micromasses in comparison with their cartilaginous co...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: Battistelli M,Borzì RM,Olivotto E,Vitellozzi R,Burattini S,Facchini A,Falcieri E

    更新日期:2005-08-15 00:00:00

  • Postembryonic development of hard jaws (trophi) in a species belonging to the Brachionus plicatilis complex (Rotifera, Monogononta): a morphometric analysis.

    abstract::The presence of hard jaws (trophi), with species-specific shape and size, is a taxonomic feature of Rotifera, a group of microscopic metazoans. Since trophi are used to discriminate among species, it is important to know whether these structures change in taxonomically important ways during postembryonic development. ...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: Fontaneto D,Melone G

    更新日期:2006-04-01 00:00:00

  • Distribution of minor collagens during skin development.

    abstract::The skin is a tissue containing a large number of collagen types. Several collagens are restricted at the dermo-epidermal junction, contrarily to others present throughout the dermis. However, the distribution of the dermal collagen varies during embryonic development. In this contribution, we have been interested in ...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章,评审


    authors: Garrone R,Lethias C,Le Guellec D

    更新日期:1997-08-15 00:00:00

  • Osteoclastic bone resorption around intraosseous screws in rat and pig mandibles.

    abstract::This report describes osteoclastic bone resorption around intraosseous fixation screws in rat and pig mandibles. These screws supported distraction devices and provided for neutral fixation following the distraction period. Progressive clinical instability of bicortical screws and radiographic and histologic evidence ...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章


    authors: Schulten AJ,Zimmermann CE,Glowacki J

    更新日期:2003-08-15 00:00:00