Transgenic models of pituitary diseases.

Abstract:

:Transgenic mice are valuable experimental models of human endocrine diseases. Targeted ablation of specific cell lineages or insertion of genes coding for releasing factors, hormones, growth factors, and oncogenes fused with appropriate promoters, or mutated genes, can induce several pituitary disorders. Various hyposecretory and hypersecretory states have been induced, some of them due to functioning pituitary adenomas. Adenohypophysial changes in such disorders have been thoroughly investigated in many of the transgenic lines. Functioning and silent pituitary adenomas resemble those seen in human patients, and are invaluable models of tumorigenesis. The available models have not been sufficiently exploited and new models are expected in the near future. In this review, the morphologic changes of the pituitary are described in transgenic mice and, when available, the ultrastructural alterations are included.

journal_name

Microsc Res Tech

authors

Stefaneanu L,Kovacs K

doi

10.1002/(SICI)1097-0029(19971015)39:2<194::AID-JEM

subject

Has Abstract

pub_date

1997-10-15 00:00:00

pages

194-204

issue

2

eissn

1059-910X

issn

1097-0029

pii

10.1002/(SICI)1097-0029(19971015)39:2<194::AID-JEM

journal_volume

39

pub_type

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