Abstract:
:Transgenic mice are valuable experimental models of human endocrine diseases. Targeted ablation of specific cell lineages or insertion of genes coding for releasing factors, hormones, growth factors, and oncogenes fused with appropriate promoters, or mutated genes, can induce several pituitary disorders. Various hyposecretory and hypersecretory states have been induced, some of them due to functioning pituitary adenomas. Adenohypophysial changes in such disorders have been thoroughly investigated in many of the transgenic lines. Functioning and silent pituitary adenomas resemble those seen in human patients, and are invaluable models of tumorigenesis. The available models have not been sufficiently exploited and new models are expected in the near future. In this review, the morphologic changes of the pituitary are described in transgenic mice and, when available, the ultrastructural alterations are included.
journal_name
Microsc Res Techjournal_title
Microscopy research and techniqueauthors
Stefaneanu L,Kovacs Kdoi
10.1002/(SICI)1097-0029(19971015)39:2<194::AID-JEMsubject
Has Abstractpub_date
1997-10-15 00:00:00pages
194-204issue
2eissn
1059-910Xissn
1097-0029pii
10.1002/(SICI)1097-0029(19971015)39:2<194::AID-JEMjournal_volume
39pub_type
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