Latanoprost-induced iris heterochromia and open-angle glaucoma: a clinicopathologic report.

Abstract:

PURPOSE:To report the histopathologic and immunohistochemical findings from the iridectomy specimen of a patient with acquired unilateral iris heterochromia due to latanoprost. PATIENT AND METHODS:A 45-year-old woman with open-angle glaucoma and unilateral iris heterochromia was evaluated for uncontrolled intraocular pressure increase. Subsequently, the patient underwent trabeculectomy with mitomycin C and an iridectomy specimen was obtained for analysis. RESULTS:The histopathologic analysis of the iridectomy specimen did not reveal any nuclear atypia, nuclear crowding, or mitotic figures. Immunohistochemical studies showed that the iris melanocytes were negative for HMB45 and S-100, and weakly positive for Melan A. CONCLUSION:Latanoprost-associated iris color change may exhibit a diffuse, uniform, dark velvet-brown appearance, thereby simulating diffuse iris melanoma. Histopathologic and immunohistochemical analysis confirmed the benign characteristics of the affected iris melanocytes.

journal_name

J Glaucoma

journal_title

Journal of glaucoma

authors

Tsai JC,Sivak-Callcott JA,Haik BG,Zhang J,McLean IW

doi

10.1097/00061198-200110000-00009

keywords:

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

411-3

issue

5

eissn

1057-0829

issn

1536-481X

journal_volume

10

pub_type

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