Abstract：
:Only the deproteinized DNA preparations of the simian adenovirus of the type 7 (SA 7) exhibited transforming and tumorigenic activity. The complex of the SA7 DNA with terminal protein (TP) did not exhibit either transforming or tumorigenic activity in cell cultures. In contrast to the transforming potential the infectious titers of the DNA - TP complex for the monkey kidney cells were 30-50 times higher than those of pure DNA. Cleavage of the SA7 DNA by specific endonucleases enhanced the tumorigenic potential of pure DNA, suppressed its infectivity and did not affect the lack of transformation capacity of the DNA - TP complex. The onc-gene was localized in the left terminal fragment with the minimal size 4,3x10(6)D in the case of R.Sal I. The tumorigenic activity was found to decrease with an increase in the size of the DNA fragment containing the onc-gene.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Ponomareva TI,Grodnitskaya NA,Goldberg EE,Chaplygina NM,Naroditsky BS,Tikchonenko TIdoi
10.1093/nar/6.9.3119keywords:
subject
Has Abstractpub_date
1979-07-11 00:00:00pages
3119-31issue
9eissn
0305-1048issn
1362-4962journal_volume
6pub_type
杂志文章abstract：:Struct2Net is a web server for predicting interactions between arbitrary protein pairs using a structure-based approach. Prediction of protein-protein interactions (PPIs) is a central area of interest and successful prediction would provide leads for experiments and drug design; however, the experimental coverage of t...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkq481
更新日期：2010-07-01 00:00:00
abstract：:We have developed an end-labelling approach to map the positions of nucleosomes and protein binding sites at nucleotide resolution by footprinting micrococcal nuclease (MNase)-sensitive sites. Using this approach we determined that the MFA2 gene and its upstream control regions have four positioned nucleosomes when tr...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/29.13.e64
更新日期：2001-07-01 00:00:00
abstract：:RNA editing by adensosine deaminases is a widespread mechanism to alter genetic information in metazoa. In addition to modifications in non-coding regions, editing contributes to diversification of protein function, in analogy to alternative splicing. However, although splicing programs respond to external signals, fa...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gks1045
更新日期：2013-01-01 00:00:00
abstract：:We describe a database of macromolecular motions meant to be of general use to the structural community. The database, which is accessible on the World Wide Web with an entry point at http://bioinfo.mbb.yale.edu/MolMovDB , attempts to systematize all instances of protein and nucleic acid movement for which there is at...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/26.18.4280
更新日期：1998-09-15 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章,评审
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更新日期：2020-01-10 00:00:00
abstract：:The InParanoid eukaryotic ortholog database (http://InParanoid.sbc.su.se/) has been updated to version 6 and is now based on 35 species. We collected all available 'complete' eukaryotic proteomes and Escherichia coli, and calculated ortholog groups for all 595 species pairs using the InParanoid program. This resulted ...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkm1020
更新日期：2008-01-01 00:00:00
abstract：:A key complication in comparative genomics for reliable gene function prediction is the existence of duplicated genes. To study the effect of gene duplication on function prediction, we analyze orthologs between pairs of genomes where in one genome the orthologous gene has duplicated after the speciation of the two ge...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gki913
更新日期：2005-10-27 00:00:00
abstract：:In the virion core of retroviruses, the genomic RNA is tightly associated with nucleocapsid (NC) protein molecules, forming the nucleocapsid structure. NC protein, a highly basic protein with two zinc fingers, is indispensable for RNA dimerization, encapsidation and the initiation of reverse transcription in avian, mu...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/21.4.831
更新日期：1993-02-25 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkq151
更新日期：2010-07-01 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkm929
更新日期：2008-01-01 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/8.1.67
更新日期：1980-01-11 00:00:00
abstract：:Most type II restriction-modification (R-M) systems produce separate endonuclease (REase) and methyltransferase (MTase) proteins. After R-M genes enter a new cell, MTase activity must appear before REase or the host chromosome will be cleaved. Temporal control of these genes thus has life-or-death consequences. PvuII ...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkn1010
更新日期：2009-02-01 00:00:00
abstract：:MobA protein, encoded by the broad host-range plasmid R1162, is required for conjugal mobilization of this plasmid. The protein is an essential part of the relaxosome, and is also necessary for the termination of strand transfer. In vitro, MobA is a nuclease specific for one of the two DNA strands of the origin of tra...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/21.19.4563
更新日期：1993-09-25 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/3.11.3001
更新日期：1976-11-01 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkw1358
更新日期：2017-05-19 00:00:00
abstract：:Recruitment of RAD18 to stalled replication forks facilitates monoubiquitination of PCNA during S-phase, promoting translesion synthesis at sites of UV irradiation-induced DNA damage. In this study, we show that RAD18 is also recruited to ionizing radiation (IR)-induced sites of DNA double-strand breaks (DSBs) forming...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkp082
更新日期：2009-04-01 00:00:00
abstract：:Procaryotic DNA polymerases contain an associated 3'----5' exonuclease activity which provides a proofreading function and contributes substantially to replication fidelity. DNA polymerases of the eucaryotic herpes-type viruses contain similar associated exonuclease activities. We have investigated the fidelity of pol...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/15.3.1185
更新日期：1987-02-11 00:00:00
abstract：:The spatio-temporal organization of chromatin in the eukaryotic cell nucleus is of vital importance for transcription, DNA replication and genome maintenance. Each of these activities is tightly regulated in both time and space. While we have a good understanding of chromatin organization in space, for example in fixe...
journal_title：Nucleic acids research
pub_type： 杂志文章,评审
doi：10.1093/nar/gkaa135
更新日期：2020-04-17 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkn516
更新日期：2008-10-01 00:00:00
abstract：:Telomeric DNAs consist of tandem repeats of G-clusters such as TTAGGG and TG1-3, which are the human and yeast repeat sequences, respectively. In the yeast Saccharomyces cerevisiae, the telomeric repeats are non-nucleosomal, whereas in humans, they are organized in tightly packaged nucleosomes. However, previous in vi...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkt1006
更新日期：2014-02-01 00:00:00
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journal_title：Nucleic acids research
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更新日期：1991-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1093/nar/22.7.1247
更新日期：1994-04-11 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkx485
更新日期：2017-07-07 00:00:00
abstract：:Chinese hamster genomic DNA sequences from the region downstream of the dihydrofolate reductase (DHFR) gene reported to contain a chromosomal origin of bidirectional DNA replication (OBR-1) were tested for their ability to support autonomous DNA replication in human cells. A 13.3 kilobase fragment containing OBR-1 and...
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doi：10.1093/nar/20.22.5971
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journal_title：Nucleic acids research
pub_type： 杂志文章
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更新日期：2017-03-17 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkq661
更新日期：2010-12-01 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
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更新日期：1988-11-25 00:00:00
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journal_title：Nucleic acids research
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doi：10.1093/nar/gkg599
更新日期：2003-07-01 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/21.1.155
更新日期：1993-01-11 00:00:00
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journal_title：Nucleic acids research
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doi：10.1093/nar/gky381
更新日期：2018-07-02 00:00:00
