Skeletal deformities induced by the intraperitoneal administration of deoxynivalenol (vomitoxin) in mice.

Abstract:

:The contamination of drinking water by organic acids, selenium deficiency and the ingestion of fungal mycotoxins are the three main aetiological factors in the development of Kashin-Beck disease. An avian tibial chondrodysplasia induced by mycotoxins has been reported. Deoxynivalenol (DON) is one of many mycotoxins produced by the most common contaminating species of fungi. The pattern of skeletal malformations induced by its administration intraperitoneally to pregnant mice is reported. Costo-vertebral segmentation abnormalities were the main deformities observed. The chondrodysplasia previously described was not seen.

journal_name

Int Orthop

authors

Debouck C,Haubruge E,Bollaerts P,van Bignoot D,Brostaux Y,Werry A,Rooze M

doi

10.1007/s002640100235

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

194-8

issue

3

eissn

0341-2695

issn

1432-5195

journal_volume

25

pub_type

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