Abstract:
:Osteosarcoma, the most common type of primary malignant tumour that develops in bone, can be classified into several different sub-types. While the majority of osteosarcomas are highly malignant, there are some low-grade variants. Since the introduction of chemotherapy into the multi-modal treatment regimen of high-grade osteosarcoma, its prognosis has impressively improved, with long-term survival being achieved in two-thirds of all patients. This review summarises current chemotherapeutic treatment strategies in classical osteosarcoma and also addresses the indication for chemotherapy in more unusual types and variants. It emphasises the need for treatment in specialised centres and within prospective, multi-institutional trials, amongst which EURAMOS1 and EURO-B.O.S.S are currently active in many European countries.
journal_name
Int Orthopjournal_title
International orthopaedicsauthors
Carrle D,Bielack SSdoi
10.1007/s00264-006-0192-xsubject
Has Abstractpub_date
2006-12-01 00:00:00pages
445-51issue
6eissn
0341-2695issn
1432-5195journal_volume
30pub_type
杂志文章,评审abstract::Bone lengthening is a surgical method which requires meticulous technique, continuous attention, and satisfactory cooperation on the part of the patient. The absence of common criteria makes it difficult both to classify the complications which arise, and to compare them with those of other authors. We report the comp...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00180230
更新日期:1994-10-01 00:00:00
abstract::One hundred and twenty-five cases of tuberculous osteomyelitis have been observed by the authors since 1968. The site of the lesion and the clinical and radiological findings have been analysed. The importance of accurate diagnosis by bacteriological and histological investigation is emphasized. Pitfalls in the differ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00266209
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Severe glenoid bone loss remains a surgical challenge. This condition is known to be associated with high rates of glenoid component failure. PURPOSE:The objective of this study was to evaluate clinical and radiological outcomes of a lateralized metal-backed 15.2-mm keeled baseplate prolonged by a thin 24.8...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-018-4249-4
更新日期:2019-09-01 00:00:00
abstract::Osteofibrous dysplasia of the tibia in children will commonly recur after surgical resection. The use of a leg brace until puberty offers a useful method of conservative management. Seven female patients, age three months to nine years at the time of brace treatment, have been followed for 3.5 to 18 years, an average ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00180213
更新日期:1992-01-01 00:00:00
abstract::This study included 15 patients with humeral shaft fractures who had no clinical, radiological or bone scan signs of healing after eight months. The patients were followed for a mean of 35.8 months. No patient was lost to follow-up. Anterior plating of humeral shaft nonunion via an anterior approach was performed usin...
journal_title:International orthopaedics
pub_type: 临床试验,杂志文章
doi:10.1007/s00264-009-0863-5
更新日期:2010-10-01 00:00:00
abstract::Ten cases of histologically proven chondromyxoid fibroma (CMF) of the foot and ankle with a mean follow-up of 6.1 years were retrospectively reviewed using the Scottish Bone Tumour Registry. The patients' mean age was 19 years; there were six males and four females. The anatomical locations were five phalangeal, three...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-005-0046-y
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:This review explores the scientific evidence for clinical, functional and imaging outcomes after surgical management of Femoroacetabular Impingement (FAI) syndrome, and assesses the methodological quality of the published literature reporting this issue. METHODS:The medical literature databases of Pubmed, Medl...
journal_title:International orthopaedics
pub_type: 杂志文章,评审
doi:10.1007/s00264-011-1443-z
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:This systematic literature review analysed the change in range of knee flexion from pre-operative values, following conventional posterior stabilised (PS) and high-flexion (H-F) PS total knee arthroplasty (TKA). METHODS:We calculated the weighted mean differences of pre- and postoperative flexion using meta-an...
journal_title:International orthopaedics
pub_type: 杂志文章,meta分析
doi:10.1007/s00264-011-1228-4
更新日期:2011-09-01 00:00:00
abstract:AIM OF THE STUDY:To determine if pre-operative radiologic minimal joint space width (mJSW) is related to the outcome of total knee arthroplasty (TKA) (primary hypothesis). Likewise, the aim was to test if pre-operative mJSW is related to prosthesis survival (secondary hypothesis). METHODS:A retrospective comparative a...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-018-4185-3
更新日期:2019-08-01 00:00:00
abstract:PURPOSE:Since the introduction of autologous chondrocyte implantation (ACI) for the treatment of cartilage defects, the initial technique has undergone several modifications. Whereas an autologous periosteum flap was used for defect coverage in first generation ACI, a standardized collagen membrane was utilized in seco...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-014-2368-0
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:Hip-joint empyema is a severe local infection that can cause general illness and, in the worst-case scenario, death by septic complications. For severe hip-joint infections, the Girdlestone arthroplasty has been an established treatment option for many decades. We describe functional midterm results after treat...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-011-1351-2
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:Restoring a neutral mechanical axis in total knee arthroplasty (TKA) (within ±3° of varus/valgus) is associated with superior functional outcome and reduced early implant failure. Using conventional alignment jigs results in malalignment in >20 % of cases. In this study, we investigated the reduction of outlier...
journal_title:International orthopaedics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00264-014-2529-1
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:The aim of this study was to compare angiogenic cytokine levels in knee osteoarthritis (OA) patients and healthy controls and to investigate the relationships between angiogenic cytokines and the OA severity. METHODS:Thirty-one knee OA patients and 15 healthy controls were recruited. Nine angiogenic cytokines ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-014-2406-y
更新日期:2014-09-01 00:00:00
abstract::In a prospective study, 33 patients with recurrent anterior dislocation of the shoulder were treated by a modified Bristow-Latarjet operation using a biodegradable poly-L-lactide expansion plug to fix the transferred coracoid bone block. The mean follow up was 12 months. No redislocations occurred. To assess incorpora...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF02484413
更新日期:1994-04-01 00:00:00
abstract:PURPOSE:The aim of the present study was to evaluate functional and quality of life outcomes after transosseous equivalent (TOE) double row suture technique for massive rotator cuff (RTC) tear repair using validated subjective and objective measures. This technique has shown promising preliminary results in RTC repair;...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-015-2720-z
更新日期:2015-06-01 00:00:00
abstract::In achondroplasts limb lengthening can restore the normal proportion of the body. The Ilizarov method of limb lengthening has been used in 37 patients, 23 of whom have had an adequate follow-up after operation. In this technique the cortex of the bone is partially cut, leaving the medulla intact; the two bone segments...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00547160
更新日期:1988-01-01 00:00:00
abstract::Patients with osteoarthritis of the knee often require bilateral knee replacement before fulfilling their full ambulatory potential. Despite extensive research there is considerable debate about the risks of performing simultaneous bilateral knee replacements under the same anaesthetic. Our aim was to compare the rela...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-007-0447-1
更新日期:2009-02-01 00:00:00
abstract:INTRODUCTION:Fracture neck of femur (hip fracture) is a very common problem among old age group. Such elderly patients usually have some comorbidities for which they may use anti-platelet therapy (such as clopidogrel, aspirin, or others) for long duration (chronic use). These anti-platelet medications might make the bl...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-020-04633-7
更新日期:2020-09-01 00:00:00
abstract::Antibiotic-associated colitis was diagnosed in 23 orthopaedic patients: 17 had abdominal symptoms, 3 had a fever and the remaining 3 had no symptoms but increasing C-reactive protein values or white blood count. The antibiotic was clindamycin in 19, cephalosporins in 3 and a combination of vancomycin and fusidic acid ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640050063
更新日期:1996-01-01 00:00:00
abstract::The aim of this study was to compare the safety and efficacy of OsteoSet®2 DBM with autologous cancellous bone in free vascularised fibular grafting for the treatment of large osteonecrotic lesions of the femoral head. Twenty-four patients (30 hips) with large osteonecrotic lesions of the femoral head (stage IIC in si...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-009-0915-x
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:The goal of the study was to evaluate long-term results of hip arthroplasty in patients with ceramic-on-ceramic articulation. METHODS:The follow-up involved 220 primary total hip arthroplasty procedures (188 patients, 101 women and 87 men) after implantation of the Mittelmeier cementless hip endoprosthesis. Th...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-012-1639-x
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:Aged patients represent a high risk group for acquiring spinal tuberculosis, and it still remains a leading cause of kyphosis and paraplegia in developing nations. Aged patients often combined with cardiovascular and respiratory disease and single lung ventilation via anterior approach surgery could result in m...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-016-3161-z
更新日期:2016-06-01 00:00:00
abstract::Acetabular retroversion may contribute to femoroacetabular impingement and lead to osteoarthritis of the hip. Retroversion has been measured on computed tomography scans. In recent years, assessment of acetabular version on anteroposterior pelvic views has gained increasing attention. We therefore aimed to determine t...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-010-1035-3
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:Total hip arthroplasty (THA) is an effective procedure for developmental dysplasia of the hip (DDH); however, it is sometimes difficult to complete for severe cases because of femoral head dislocation, dysplasia of the acetabulum and the femur, disparity in limb length, soft tissue contraction, and muscular atr...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-012-1622-6
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:Percutaneous endoscopic discectomy is an effective minimally invasive spine surgery (MISS) for soft disc herniations. The objective of this review was to describe the current indications, surgical techniques, and clinical outcomes of endoscopic spine surgery. METHODS:A narrative review was performed with a foc...
journal_title:International orthopaedics
pub_type: 杂志文章,评审
doi:10.1007/s00264-018-04283-w
更新日期:2019-04-01 00:00:00
abstract::We measured the size and volume of the femoral broaches and stems supplied with three commercial total hip replacement (THR) systems (JRI Furlong, Biomet Stanmore, and Howmedica Exeter). Using an in vitro method, we created cement mantles that could be directly measured. The broaches supplied with the Biomet Stanmore ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-003-0509-y
更新日期:2004-02-01 00:00:00
abstract:PURPOSE:The aims of this retrospective study were to firstly introduce three practical bulk bone graft techniques based on acetabular morphology for dysplasia and secondly evaluate the long-term durability of acetabular reconstruction using those techniques combined with cemented total hip arthroplasty (THA). METHODS:...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-015-3039-5
更新日期:2016-09-01 00:00:00
abstract:PURPOSES:Post arthroplasty gait analysis has up till now been performed on subjects walking slowly on flat ground rather than challenging them at faster speeds or walking uphill. We therefore asked: (1) Is there a measurable difference in the performance of hip resurfacing arthroplasty (HRA) and total hip arthroplasty ...
journal_title:International orthopaedics
pub_type: 临床试验,杂志文章
doi:10.1007/s00264-013-1819-3
更新日期:2013-05-01 00:00:00
abstract::The tendon sheaths of extensor pollicis brevis (EPB) and abductor pollicis longus (APL), obtained from four patients with de Quervain's disease were studied by light and electron microscopy. Three different layers were identified in the sheath which was much thicker than normal. Both the outer and the middle layers ha...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00267036
更新日期:1985-01-01 00:00:00
abstract::There is currently an increased interest in the use of electro surgery in arthroscopy. Since the introduction of the bipolar arthroscopic radiofrequency (RF) wand, it has started to replace the classic Bovie monopolar probe on the assumption that the new technology provides multifunctional devices, combining both tiss...
journal_title:International orthopaedics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00264-008-0541-z
更新日期:2009-02-01 00:00:00