Abstract:
PURPOSE:Since the introduction of autologous chondrocyte implantation (ACI) for the treatment of cartilage defects, the initial technique has undergone several modifications. Whereas an autologous periosteum flap was used for defect coverage in first generation ACI, a standardized collagen membrane was utilized in second generation ACI. To date, however, no study has proven the superiority of this modification in terms of long-term clinical outcome. The purpose of this matched-pair analysis was therefore to compare the clinical long-term outcome of first and second generation ACI with a minimum follow-up of ten years. METHODS:A total of 23 patients treated with second generation ACI for isolated cartilage defects of the knee were evaluated after a minimum follow-up of ten years using Lysholm and IKDC scores. The results of these patients were compared to those of 23 matched patients treated with first generation ACI. Pair wise matching was performed by defect location, patient age, and defect size. RESULTS:While all patient characteristics such as age (31.7 years SD 6.9 vs. 31.4 years SD 7.8), defect size (5.1 cm² SD 2.3 vs. 4.9 cm² SD 1.5), and follow-up time (10.7 months SD 1.0 vs. 10.5 months SD 0.6) were distributed homogenously in both treatment groups, significant better Lysholm (82.7 SD 9.9 versus 75.6 SD 11.8; p = 0.031) and IKDC scores (76.4 SD 12.8 versus 68.0 SD 12.0, p = 0.023) were found in the group of patients treated with second generation ACI compared to those treated with first generation ACI. In both groups, four patients (17.4%) received surgical reintervention during follow-up. CONCLUSIONS:The use of a collagen membrane in combination with autologous chondrocytes (second generation ACI) leads to superior clinical long-term outcome compared to first generation ACI. Based on these results, second generation ACI should be preferred over first generation ACI.
journal_name
Int Orthopjournal_title
International orthopaedicsauthors
Niemeyer P,Salzmann G,Feucht M,Pestka J,Porichis S,Ogon P,Südkamp N,Schmal Hdoi
10.1007/s00264-014-2368-0subject
Has Abstractpub_date
2014-10-01 00:00:00pages
2065-70issue
10eissn
0341-2695issn
1432-5195journal_volume
38pub_type
杂志文章abstract::We used custom mega-prostheses in 57 patients with aggressive benign and malignant tumours of the proximal humerus. The most common tumour was osteosarcoma, followed by giant cell tumour and chondrosarcoma. We achieved extra-articular and wide resection margins in all primary malignant tumours and narrow margins in be...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-005-0029-z
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:To determine the optimal position of reduction clamps applied to reduce transtectal transverse acetabular fractures approached through the anterior intrapelvic route. METHODS:Transtectal transverse fractures were created in sawbone hemipelvis models. Fractures were reduced and held with a large pointed reducti...
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doi:10.1007/s00264-019-04430-x
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doi:10.1007/s00264-010-1072-y
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journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640050174
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abstract:PURPOSE:Adolescent idiopathic scoliosis (AIS) is reported to be associated with the two traditional estrogen receptor genes, ESR1 and ESR2. Yet, the novel estrogen receptor G protein-coupled estrogen receptor 1 (GPER) has not been studied. To investigate the association of GPER gene polymorphisms with the onset and det...
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doi:10.1007/s00264-011-1374-8
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journal_title:International orthopaedics
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更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00269912
更新日期:1984-01-01 00:00:00
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journal_title:International orthopaedics
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pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00
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更新日期:2011-11-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-01-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00178764
更新日期:1990-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-03-01 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
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更新日期:2016-10-01 00:00:00
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journal_title:International orthopaedics
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更新日期:2001-01-01 00:00:00
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更新日期:2020-09-01 00:00:00
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更新日期:2020-09-19 00:00:00
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journal_title:International orthopaedics
pub_type: 杂志文章,评审
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更新日期:1989-01-01 00:00:00
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更新日期:2004-10-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2013-07-01 00:00:00