Abstract：
PURPOSE:The aim of this study was to compare angiogenic cytokine levels in knee osteoarthritis (OA) patients and healthy controls and to investigate the relationships between angiogenic cytokines and the OA severity. METHODS:Thirty-one knee OA patients and 15 healthy controls were recruited. Nine angiogenic cytokines (angiopoietin-2, follistatin, granulocyte-colony stimulating factor (G-CSF), hepatocyte growth factor (HGF), interleukin (IL)-8, leptin, platelet-derived growth factor-BB (PDGF-BB), platelet endothelial cell adhesion molecule (PECAM)-1, and vascular endothelial growth factor (VEGF)) in plasma and synovial fluid were measured using a multiplex immunoassay. RESULTS:PECAM-1, HGF, VEGF, angiopoietin-2, follistatin, G-CSF, and IL-8 concentrations in plasma were significantly higher in OA patients than those in controls. Plasma angiopoietin-2 was significantly greater in advanced OA than in early OA. Synovial fluid VEGF was positively correlated with the severity (r = 0.367, P = 0.04). Plasma follistatin was significantly lower in advanced knee OA than in early OA and was negatively correlated with the severity (r = -0.374, P < 0.05). CONCLUSIONS:Angiogenic cytokine concentrations in plasma can distinguish between controls and OA patients. Local and circulating levels of angiogenic cytokines could give an insight into the pathophysiology of OA. Follistatin, angiopoietin-2, and VEGF may have potential as biochemical markers for the assessment of OA severity.
journal_name
Int Orthopjournal_title
International orthopaedicsauthors
Mabey T,Honsawek S,Saetan N,Poovorawan Y,Tanavalee A,Yuktanandana Pdoi
10.1007/s00264-014-2406-ysubject
Has Abstractpub_date
2014-09-01 00:00:00pages
1885-92issue
9eissn
0341-2695issn
1432-5195journal_volume
38pub_type
杂志文章abstract：PURPOSE:The aim of this study was to analyse the clinical outcome of a modified Sever-L'Episcopo technique for release of contracted muscles and tendon transfer to restore function of the shoulder joint in patients with Erb's palsy. METHODS:A case series was conducted from March 1988 to November 2009 for 19 patients. ...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-014-2592-7
更新日期：2015-02-01 00:00:00
abstract：:We report the outcome of 50 patients with degenerative lumbar spinal stenosis who were treated surgically by spinal decompression between 1984 and 1995. Their mean age at the time of surgery was 59.9 (45-77) years and the mean follow-up was 11.6 (6.1-17.2) years. Five patients had a concomitant spinal fusion. The preo...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-005-0030-6
更新日期：2006-02-01 00:00:00
abstract：PURPOSE:The use of total hip arthroplasty (THA) to treat advanced tuberculous arthritis, particularly during the active phase, is challenging. The aim of this study was to evaluate the efficacy of cementless THA for advanced hip joint tuberculosis. METHODS:This study reviewed 32 patients (mean age at surgery, 49.4 yea...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-015-2997-y
更新日期：2015-11-01 00:00:00
abstract：AIM OF THE STUDY:The aim of the study was to investigate functional and patient-rated outcome parameters after endoscopic assisted release of the ulnar nerve for cubital tunnel syndrome. METHODS:One hundred of 204 consecutive patients between 2006 and 2011 met the inclusion/exclusion criteria. Fifty-one of these patie...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-018-3760-y
更新日期：2018-06-01 00:00:00
abstract：:Precise evaluation of bone loss and bone viability is necessary in order to select the most appropriate operation for patients with osteonecrosis of the femoral head. Bone destruction, and its exact location, can be assessed by computed axial tomography. The viability of remaining bone can be observed at operation by ...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00269498
更新日期：1983-01-01 00:00:00
abstract：:We used scanning electron microscopy to perform an ultrastructural analysis and two optical interferometric profilers to measure roughness on 40 prosthetic femoral heads. We expressed roughness as Ra (roughness average) value and Rsk (roughness skewness) value. Our results show that in order to obtain an ideal surface...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s002640000129
更新日期：2000-01-01 00:00:00
abstract：:Twenty children with grade IV supracondylar fractures of the humerus had an open reduction 11 to 17 days after injury. The delay was due to swelling and blisters. Most patients recovered a useful range of movement and there were no complications. A posterior approach with V-Y plasty of the triceps makes it easy to ali...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00192291
更新日期：1991-01-01 00:00:00
abstract：:The aim of this prospective study was to determine the effect of screening for methicillin-resistant Staphylococcus aureus (MRSA), in patients undergoing total hip and knee replacements, on reducing hospital-acquired infections and the length of hospital stay. We included 395 patients admitted to the elective orthopae...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-005-0649-3
更新日期：2005-06-01 00:00:00
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journal_title：International orthopaedics
pub_type： 临床试验,杂志文章
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更新日期：2007-02-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-012-1545-2
更新日期：2012-09-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-020-04804-6
更新日期：2021-02-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-016-3260-x
更新日期：2017-09-01 00:00:00
abstract：:The authors report seven cases of desmoid tumors of the extremities. A tumour less than a few centimetres in size is best removed by wide local excision. Large growths should also be excised, but efforts should be made to preserve the vessels and nerves, since malignant transformation and metastases do not occur. Irra...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00547171
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:Deterioration of gait in adolescent and adult patients with cerebral palsy can be associated with multiple factors. Multilevel surgery (MLS) is one option in adults with cerebral palsy to improve gait function with encouraging short-term results. It is a question whether these improvements are maintained ove...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-018-4023-7
更新日期：2019-02-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s002640050388
更新日期：1999-01-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-003-0506-1
更新日期：2004-02-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-014-2430-y
更新日期：2014-10-01 00:00:00
abstract：:Total hip arthroplasty (THA) is one of the most successful operations that can restore function and relieve pain. Although a majority of the patients achieve significant pain relief after THA, there are a number of patients that develop chronic pain for unknown reasons. A literature search was performed looking for ch...
journal_title：International orthopaedics
pub_type： 杂志文章,评审
doi：10.1007/s00264-012-1711-6
更新日期：2013-01-01 00:00:00
abstract：:Hans von Gerssdorff and Hieronymus Brunschwig, who flourished in Germany in the latter half of the fifteenth century, have both left early printed treatises on Surgery which give excellent woodcuts showing pictures of instruments, operations, and costumes, at the end of the medieval period. Hieronymus Brunschwig or Hi...
journal_title：International orthopaedics
pub_type： 传,历史文章,杂志文章
doi：10.1007/s00264-015-2868-6
更新日期：2015-10-01 00:00:00
abstract：PURPOSE:The review aims to provide a summary of the current literature regarding common medications prescribed in orthopaedic surgery and their potential implications in COVID-19 patients. METHODS:A systematic review was performed using the PRISMA guidelines. All clinical studies, reviews, consensus and guidelines rel...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-020-04643-5
更新日期：2020-08-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-018-4108-3
更新日期：2019-07-01 00:00:00
abstract：:We have treated 350 displaced Colles fractures by percutaneous fixation with K wires arranged in a 'basket' formation, as described by Kapandji. This technique enables satisfactory stabilisation of the fragments and early mobilisation and rehabilitation, usually without the use of a plaster cast or brace. We describe ...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00266982
更新日期：1988-01-01 00:00:00
abstract：:In this prospective study, our aim was to compare the functional results and radiographic outcomes of fusion and Bryan Cervical Disc replacement in the treatment of two-level cervical disc disease. A total of 65 patients with two-level cervical disc disease were randomly assigned to two groups, those operated on with ...
journal_title：International orthopaedics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00264-008-0655-3
更新日期：2009-10-01 00:00:00
abstract：PURPOSE:The management of calcaneal fractures remains challenging and often controversial. Open reduction and internal fixation with a lateral plate has been established as a standard therapy for displaced articular fractures. However, accurate subtalar joint reduction, while mandatory, is difficult to achieve, require...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-011-1249-z
更新日期：2011-07-01 00:00:00
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journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-002-0423-8
更新日期：2003-01-01 00:00:00
abstract：:We treated 25 patients with aggressive and malignant fibular tumours between April 1989 and May 2001. There were 11 osteosarcomas, seven Ewing's sarcoma and five chondrosarcomas. The tumours predominantly involved the upper one third; 16 were of Stage IIB. Neo-adjuvant and adjuvant chemotherapy were given to all patie...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-004-0566-x
更新日期：2004-10-01 00:00:00
abstract：PURPOSE:Coracoclavicular joint (CCJ) is a rare anomalous joint occasionally found between the coracoid process of scapula and the conoid tubercle of clavicle. The articulation has been extensively studied by means of anatomical, osteological and radiological investigations. Most cases are discovered incidentally, with ...
journal_title：International orthopaedics
pub_type： 杂志文章,评审
doi：10.1007/s00264-011-1309-4
更新日期：2011-12-01 00:00:00
abstract：:A prospective randomised trial of treatment of ruptured ankle ligaments was carried out at our institute. Two hundred patients were randomly assigned to 4 treatment groups. The results at 1 and 2 years after injury showed that functional treatment with a newly designed brace appeared to be the method of choice. This g...
journal_title：International orthopaedics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00192302
更新日期：1991-01-01 00:00:00
abstract：PURPOSE:Endothelial dysfunction is a risk factor for osteonecrosis of femoral head (ONFH) and venous thromboembolism (VTE) [defined as deep venous thrombosis (DVT) or pulmonary embolism (PE)]. However, the risk of unprovoked VTE in non-traumatic ONFH patients remains unclear. METHODS:We investigated the relationship b...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-018-3866-2
更新日期：2018-07-01 00:00:00
abstract：:The measure of radiographic pelvic and spinal parameters for sagittal balance analysis has gained importance in reconstructive surgery of the spine and particularly in degenerative spinal diseases (DSD). Fusion in the lumbar spine may result in loss of lumbar lordosis (LL), with possible compensatory mechanisms: decre...
journal_title：International orthopaedics
pub_type： 杂志文章,评审
doi：10.1007/s00264-014-2516-6
更新日期：2015-01-01 00:00:00
