Surgical management of neuroblastoma.

Abstract:

:Neuroblastoma treatment remains challenging but has been advanced by the establishment of clinical and biological variables that determine prognostic risk. Risk-based therapy currently is the hallmark of neuroblastoma treatment. Initially, stage and age were the prime determinants of survival used in clinical practice. The Shimada histopathologic classification added to the former 2 and biochemical markers like the serum ferritin, lactic dehydrogenase, and neuron-specific enolase also provided information regarding prognosis. The current era of neuroblastoma therapy has been influenced heavily by advances in molecular biology, most notably the identification of the MYCN oncogene and the application of recombinant DNA methods to identification of chromosomal deletions. Current risk assessment includes age, stage, histopathology, and biochemical markers but also analyses performed on DNA extracted from fresh tumors. This places the onus of obtaining an adequate quantity and quality of fresh neuroblastoma tissue directly on the pediatric surgeon who performs the initial biopsy.

journal_name

Semin Pediatr Surg

authors

La Quaglia MP

doi

10.1053/spsu.2001.24889

keywords:

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

132-9

issue

3

eissn

1055-8586

issn

1532-9453

pii

S1055858601000294

journal_volume

10

pub_type

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