Abstract:
:Neuroblastoma treatment remains challenging but has been advanced by the establishment of clinical and biological variables that determine prognostic risk. Risk-based therapy currently is the hallmark of neuroblastoma treatment. Initially, stage and age were the prime determinants of survival used in clinical practice. The Shimada histopathologic classification added to the former 2 and biochemical markers like the serum ferritin, lactic dehydrogenase, and neuron-specific enolase also provided information regarding prognosis. The current era of neuroblastoma therapy has been influenced heavily by advances in molecular biology, most notably the identification of the MYCN oncogene and the application of recombinant DNA methods to identification of chromosomal deletions. Current risk assessment includes age, stage, histopathology, and biochemical markers but also analyses performed on DNA extracted from fresh tumors. This places the onus of obtaining an adequate quantity and quality of fresh neuroblastoma tissue directly on the pediatric surgeon who performs the initial biopsy.
journal_name
Semin Pediatr Surgjournal_title
Seminars in pediatric surgeryauthors
La Quaglia MPdoi
10.1053/spsu.2001.24889keywords:
subject
Has Abstractpub_date
2001-08-01 00:00:00pages
132-9issue
3eissn
1055-8586issn
1532-9453pii
S1055858601000294journal_volume
10pub_type
杂志文章abstract::The salivary glands comprise three main pairs of glands (ie, the parotid, the submandibular, and the sublingual) and a number of minor glands found in the mucosa of the upper aerodigestive tract. Lesions may be inflammatory or obstructive in nature or may stem from granulomatous or neoplastic disease. As such, establi...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/j.sempedsurg.2006.02.004
更新日期:2006-05-01 00:00:00
abstract::Minimally invasive surgical approaches to various pediatric surgical disease processes are becoming the standard of care. Laparoscopic Nissen fundoplication is transitioning toward the preferred method for the surgical correction of gastroesophageal reflux (GER) disease in infants and children that do not respond to m...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/spsu.2002.35349
更新日期:2002-11-01 00:00:00
abstract::Management strategies for infants with very low birth weight (VLBW) who have abdominal wall defects essentially are the same as for those in larger infants. The authors favor primary closure in infants with gastroschisis, and have achieved this goal in 91% of infants since 1985. Treatment of infants with omphalocele i...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章
doi:10.1016/s1055-8586(00)70022-9
更新日期:2000-05-01 00:00:00
abstract::Neuroblastoma is a heterogenous disease, with solid tumors arising in the adrenal gland or paraspinal regions in young children. Neuroblastoma is unique, with varied presentation and prognosis based on primary location and tumor stage. Tumor behavior and response to treatment ranges from spontaneous regression to diss...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1016/j.sempedsurg.2019.150859
更新日期:2019-12-01 00:00:00
abstract::The pathogenesis of necrotizing enterocolitis (NEC) is poorly understood, but appears to be multifactorial and highly associated with immaturity of the gastrointestinal tract, colonization of the intestinal microbiota, and immature innate immune system. The goal of this review is to provide an overview of some of thes...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/j.sempedsurg.2005.05.001
更新日期:2005-08-01 00:00:00
abstract::Most children with short bowel syndrome experience spontaneous small bowel adaptation over time. This allows the majority to be weaned from parenteral nutrition. There are, however, some children who cannot be weaned and are potential candidates for techniques to promote intestinal adaptation and intestinal lengthenin...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/spsu.2001.22855
更新日期:2001-05-01 00:00:00
abstract::Hirschsprung disease affects many children every year around the world. Currently, there is an extensive menu of diagnostic methods, and surgical treatments. This situation compels the physicians to follow the rationale of these interventions. The comprehensive diagnosis and treatment of Hirschsprung disease need sing...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/j.sempedsurg.2019.04.013
更新日期:2019-06-01 00:00:00
abstract::Identification of CDH infant populations at high risk for mortality postnatally may help to develop targeted care strategies, guide discussions surrounding palliation and contribute to standardizing reporting and benchmarking, so that care strategies at different centers can be compared. Clinical prediction rules are ...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/j.sempedsurg.2017.04.010
更新日期:2017-06-01 00:00:00
abstract::The practice of pediatric surgery is at the crossroads of 2 specialties, pediatrics and surgery. At that vantage point, many ethical dilemmas can be seen. It is important for the pediatric surgeon to understand the special place of ethics in the care of children and how that care is influenced by society. The purpose ...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/spsu.2001.26837
更新日期:2001-11-01 00:00:00
abstract::During the past 10 years, the minimally invasive technique has become the standard approach for many thoracic, abdominal, and pelvic procedures in adults and children. We now know there are well-defined benefits to this approach. However, when it was introduced, the laparoscopic technique was quickly adopted without a...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/j.sempedsurg.2011.05.008
更新日期:2011-11-01 00:00:00
abstract::Inflammatory bowel disease in childhood refers to ulcerative colitis, Crohn's disease, and colitis of an indeterminate type. Their gross and microscopic features are discussed along with the differential diagnosis from other childhood conditions associated with bloody diarrhea. ...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/j.sempedsurg.2007.04.005
更新日期:2007-08-01 00:00:00
abstract::Congenital diaphragmatic hernia (CDH) is a common structural birth defect that affects approximately 1 in 2500 live births. Although the exact etiology of most cases of CDH remains unknown, it is becoming increasingly clear that genetic factors play an important role in many cases of CDH. In this paper, we review crit...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/j.sempedsurg.2007.01.003
更新日期:2007-05-01 00:00:00
abstract::Biliary atresia (BA) remains an enigmatic disease with a degree of etiologic heterogeneity. A number of variants can be defined clinically, and these include the syndromic group (typically BA splenic malformation), cystic BA, and cytomegalovirus (CMV) IgM +ve associated BA. The remainder, and still the largest group, ...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/j.sempedsurg.2012.05.010
更新日期:2012-08-01 00:00:00
abstract::Nutritional management of infants and children differs from that of adults because of the extra requirements for growth and the limitations of physiological immaturity. Although parenteral nutrition (PN) is an accepted practice and a potentially life-saving therapy for pediatric patients who cannot be fed through thei...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:
更新日期:1992-08-01 00:00:00
abstract::The multi-disciplinary team is essential for the success of an adolescent bariatric surgical program. This article will describe the components of the team and their roles. Essential members include a pediatrician or pediatric subspecialist with an interest and expertise in adolescent obesity, a pediatric surgeon with...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/j.sempedsurg.2013.10.012
更新日期:2014-02-01 00:00:00
abstract::Pediatric heart transplantation has undergone major changes over the past two decades, marked by a substantial improvement in survival, reduction in posttransplant complications, and enhancement in quality of life for transplant recipients. Actuarial survival has improved substantially in the last decade. Indications ...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/j.sempedsurg.2006.03.011
更新日期:2006-08-01 00:00:00
abstract::Hemangiomas, cystic hygromas, and teratomas are the most common bulky lesions presenting in the head and neck of infants, but cystic hygromas and teratomas are rare, and most hemangiomas are initially small. Historically, hemangiomas have been watched with the belief that they all involute with good results. Recogniti...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:
更新日期:1994-08-01 00:00:00
abstract::The treatment of children who have major abdominal injuries has changed significantly during the past 2 decades. Surgical restraint has been the theme, and increased awareness of anatomic patterns and physiological responses has prompted successful nonoperative care of many solid organ injuries in children. The contri...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:
更新日期:1995-05-01 00:00:00
abstract::Disorders of sexual development (DSDs) are relatively rare congenital conditions in which the development of the chromosomal, gonadal, or anatomic sex is atypical. Some conditions may not manifest until puberty or adulthood. The examination and workup of either an infant or an older patient with suspected DSD should b...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/j.sempedsurg.2015.01.009
更新日期:2015-04-01 00:00:00
abstract::Necrotizing enterocolitis (NEC) continues to afflict approximately 7% of preterm infants born weighing less than 1500g, though recent investigations have provided novel insights into the pathogenesis of this complex disease. The disease has been a major cause of morbidity and mortality in neonatal intensive care units...
journal_title:Seminars in pediatric surgery
pub_type: 历史文章,杂志文章,评审
doi:10.1053/j.sempedsurg.2017.11.003
更新日期:2018-02-01 00:00:00
abstract::Obesity affects 50% of adults and 18% of children in the USA. It has wide-ranging comorbidities with clinical, psychosocial, and economic ramifications. Obesity refers to a condition of excess body fat. The basis for weight gain is a fundamental imbalance between caloric intake and output, but individual variation bas...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章
doi:10.1053/j.sempedsurg.2009.04.008
更新日期:2009-08-01 00:00:00
abstract::Telemedicine, the remote diagnosis and treatment of patients by means of technology, provides an alternative means for patients to gain access to health care services. Telemedicine is a general term that includes the use of various communication technologies, including telephone, email, or videoconferencing. Telemedic...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/j.sempedsurg.2018.02.007
更新日期:2018-04-01 00:00:00
abstract::Even if no large comparative studies enable us to definitely confirm the potential advantages of minimal retroperitoneoscopic access surgery, this new technique is now expanding in pediatric urology and considered today as feasible and safe in well-trained hands. The technique is described in detail; the main indicati...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章
doi:10.1053/j.sempedsurg.2007.06.010
更新日期:2007-11-01 00:00:00
abstract::Management of pediatric intestinal failure has evolved in recent decades, with improved survival since the advent of specialized multidisciplinary intestinal failure centers. Though sepsis and intestinal failure associated liver disease still contribute to mortality, we now have growing data on the long-term outcomes ...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/j.sempedsurg.2017.09.006
更新日期:2017-10-01 00:00:00
abstract::Traditionally, pediatric surgical education consisted of exposure to patients, textbooks, lectures, team-based education, congresses, and workshops. Over the last decades, however, new information technology (IT) and the internet revolutionized the sharing of information and communication. IT has become relevant in pa...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/j.sempedsurg.2015.02.012
更新日期:2015-06-01 00:00:00
abstract::Colorectal disease profiles for children in low- and middle-income settings (LMIC) are characterized by late presentation, increased complications and limited follow-up in many cases. There is a high prevalence of infectious conditions causing secondary colorectal disease such as Mycobacterium Tuberculosis(TB), Human ...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章
doi:10.1016/j.sempedsurg.2020.150989
更新日期:2020-12-01 00:00:00
abstract::Enterocolitis remains a relatively common complication of Hirschsprung's disease with significant morbidity and mortality. The etiology of Hirschsprung's enterocolitis (HEC) is multifactorial and remains poorly understood. Preventative measures and better treatment modalities will evolve out of a better understanding ...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/j.sempedsurg.2004.10.014
更新日期:2004-11-01 00:00:00
abstract::The management of conjoined twins falls into three distinct groups-non-operative, emergency separation and elective separation. Planning meetings involving all the personnel who will be required during the operation are held. The radiological findings are presented and the anaesthetic, nursing and intensive care requi...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章
doi:10.1053/j.sempedsurg.2015.06.004
更新日期:2015-10-01 00:00:00
abstract::This review of parathyroid surgery in children will briefly discuss parathyroid gland embryology and anatomy before focusing on the pathophysiology, clinical presentation, and treatment of hyperparathyroidism in children. Hyperparathyroidism (HPT) is the overproduction of PTH and it is rare in children, with an incide...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/j.sempedsurg.2014.03.003
更新日期:2014-04-01 00:00:00
abstract::The fallopian tubes are the essential genital ducts that convey the female sex cells for fertilization. They are differentiated and detectable early in fetal life. There are numerous paratubal and tubal abnormalities that can occur at any point in the female life. Some of these are rare but may initiate significant mo...
journal_title:Seminars in pediatric surgery
pub_type: 杂志文章,评审
doi:10.1053/j.sempedsurg.2005.01.009
更新日期:2005-05-01 00:00:00