Intestinal innate immunity: how does it relate to the pathogenesis of necrotizing enterocolitis.

Abstract:

:The pathogenesis of necrotizing enterocolitis (NEC) is poorly understood, but appears to be multifactorial and highly associated with immaturity of the gastrointestinal tract, colonization of the intestinal microbiota, and immature innate immune system. The goal of this review is to provide an overview of some of these risk factors and how they might lead to the genesis of NEC. A better understanding of these factors should help us prevent and treat this devastating disease.

journal_name

Semin Pediatr Surg

authors

Neu J,Chen M,Beierle E

doi

10.1053/j.sempedsurg.2005.05.001

keywords:

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

137-44

issue

3

eissn

1055-8586

issn

1532-9453

pii

S1055-8586(05)00029-6

journal_volume

14

pub_type

杂志文章,评审
  • Outcomes in pediatric trauma care.

    abstract::Variation in clinical practice patterns has attracted the attention of specialty organizations, payers, government health agencies, and the public. Such variation raises concerns about efficacy and cost relative to the care provided. Consequently, the establishment of national benchmarks has become an increasing prior...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章

    doi:10.1053/j.sempedsurg.2008.02.006

    authors: Stylianos S,Ford HR

    更新日期:2008-05-01 00:00:00

  • Pediatric germ cell tumors.

    abstract::Pediatric germ cell tumors represent a diverse group of tumors that present from in utero through adolescence at many nongonadal locations, from the neck to the sacrococcygeal region. Surgical resection remains the central element of management, and accurate surgical staging is essential to properly ascertain the corr...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1053/j.sempedsurg.2011.10.005

    authors: Rescorla FJ

    更新日期:2012-02-01 00:00:00

  • Gastrointestinal bleeding in infants and children: Meckel's diverticulum and intestinal duplication.

    abstract::Gastrointestinal bleeding in infants and children can be quite alarming and anxiety-provoking for parents and caregivers alike. In most cases the cause is benign, and the course self-limited. However, in the patient with significant bleeding, an aggressive diagnostic approach is warranted. The differential diagnosis c...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1016/s1055-8586(99)70027-2

    authors: Brown RL,Azizkhan RG

    更新日期:1999-11-01 00:00:00

  • Error traps and culture of safety in Hirschsprung disease.

    abstract::Hirschsprung disease affects many children every year around the world. Currently, there is an extensive menu of diagnostic methods, and surgical treatments. This situation compels the physicians to follow the rationale of these interventions. The comprehensive diagnosis and treatment of Hirschsprung disease need sing...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1053/j.sempedsurg.2019.04.013

    authors: De La Torre L,Wehrli LA

    更新日期:2019-06-01 00:00:00

  • MIBG in neuroblastoma diagnosis and treatment.

    abstract::Neuroblastoma is a heterogenous disease, with solid tumors arising in the adrenal gland or paraspinal regions in young children. Neuroblastoma is unique, with varied presentation and prognosis based on primary location and tumor stage. Tumor behavior and response to treatment ranges from spontaneous regression to diss...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.sempedsurg.2019.150859

    authors: Olecki E,Grant CN

    更新日期:2019-12-01 00:00:00

  • Telemedicine in the perioperative experience.

    abstract::Telemedicine, the remote diagnosis and treatment of patients by means of technology, provides an alternative means for patients to gain access to health care services. Telemedicine is a general term that includes the use of various communication technologies, including telephone, email, or videoconferencing. Telemedic...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1053/j.sempedsurg.2018.02.007

    authors: Lesher AP,Shah SR

    更新日期:2018-04-01 00:00:00

  • Enterocolitis complicating Hirschsprung's disease.

    abstract::Enterocolitis remains a relatively common complication of Hirschsprung's disease with significant morbidity and mortality. The etiology of Hirschsprung's enterocolitis (HEC) is multifactorial and remains poorly understood. Preventative measures and better treatment modalities will evolve out of a better understanding ...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1053/j.sempedsurg.2004.10.014

    authors: Vieten D,Spicer R

    更新日期:2004-11-01 00:00:00

  • Pancreatic islet transplantation.

    abstract::Pancreatic islet transplantation is a minimally invasive treatment that has the potential to prevent diabetes after total pancreatectomy for benign disease (islet autotransplantation) and to reverse diabetes in those with type 1 diabetes (islet allotransplantation). In both scenarios, the treatment involves extracting...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1053/j.sempedsurg.2012.05.012

    authors: Johnson PR,Jones KE

    更新日期:2012-08-01 00:00:00

  • Difficult esophageal atresia: trick and treat.

    abstract::Although most patients with esophageal atresia (EA) and tracheo-esophageal fistula (TEF) may benefit from "standard" management, which is deferred emergency surgery, some may present unexpected elements that change this paradigm. Birth weight, associated anomalies, and long gap can influence the therapeutic schedule o...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1053/j.sempedsurg.2014.09.006

    authors: Conforti A,Morini F,Bagolan P

    更新日期:2014-10-01 00:00:00

  • Delayed fistulization from esophageal replacement surgery.

    abstract::We present two patients who developed delayed fistulization following esophageal replacement surgery. The first is a 13-year-old child who, at the age of 3 years, underwent a trans-mediastinal colonic esophageal replacement for a refractory corrosive injury followed by a retrosternal reverse gastric tube after an earl...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章

    doi:10.1053/j.sempedsurg.2009.02.008

    authors: Abdalwahab A,Al Namshan M,Al Rabeeah A,Laberge JM

    更新日期:2009-05-01 00:00:00

  • How young for bariatric surgery in children?

    abstract::Obesity affects 50% of adults and 18% of children in the USA. It has wide-ranging comorbidities with clinical, psychosocial, and economic ramifications. Obesity refers to a condition of excess body fat. The basis for weight gain is a fundamental imbalance between caloric intake and output, but individual variation bas...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章

    doi:10.1053/j.sempedsurg.2009.04.008

    authors: Browne AF,Inge T

    更新日期:2009-08-01 00:00:00

  • Jejunum for bridging long-gap esophageal atresia.

    abstract:OBJECTIVE:Exploring pros and cons of bridging long-gap esophageal atresia with an orthotopic jejunal pedicle graft. Retrospective series of 19 patients. METHODS:From 1988 through 2005, 19 patients with long-gap esophageal atresia received a jejunal graft. Median age at reconstruction was 76 days. The technique involve...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章

    doi:10.1053/j.sempedsurg.2008.10.007

    authors: Bax KM

    更新日期:2009-02-01 00:00:00

  • Necrotizing enterocolitis: Pathophysiology from a historical context.

    abstract::Necrotizing enterocolitis (NEC) continues to afflict approximately 7% of preterm infants born weighing less than 1500g, though recent investigations have provided novel insights into the pathogenesis of this complex disease. The disease has been a major cause of morbidity and mortality in neonatal intensive care units...

    journal_title:Seminars in pediatric surgery

    pub_type: 历史文章,杂志文章,评审

    doi:10.1053/j.sempedsurg.2017.11.003

    authors: Hackam D,Caplan M

    更新日期:2018-02-01 00:00:00

  • Imaging techniques to assess the pelvis in young females.

    abstract::This article is designed to help the nonradiologist to form a logical imaging plan when presented with a diagnostic dilemma involving the pelvis of a young female. Common presenting problems are grouped under the categories of fetus, neonate and infant, child, and adolescent. Ultrasound is frequently the initial, and ...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1016/s1055-8586(98)70008-3

    authors: Barnewolt CE

    更新日期:1998-02-01 00:00:00

  • Modern burn care.

    abstract::In the United States nearly 2 million people are burned every year; about 100,000 burns are moderate to severe and require hospitalization and about 5,000 deaths occur because of burns. The overall improvement in mortality and outcome of patients with severe burn trauma over the last decades can be attributed to the f...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章

    doi:10.1053/spsu.2001.19389

    authors: Herndon DN,Spies M

    更新日期:2001-02-01 00:00:00

  • Radiologic diagnosis of a newborn with cloaca.

    abstract::When a female is born and has only a single perineal orifice on the newborn clinical examination, a diagnosis of cloaca type of anorectal malformation is made. Along with associated malformations which may initiate the ordering of radiologic imaging, there are a finite number of radiologic tests that are performed to ...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1053/j.sempedsurg.2015.11.007

    authors: Kraus SJ

    更新日期:2016-04-01 00:00:00

  • Biliary atresia: clinical aspects.

    abstract::Biliary atresia (BA) remains an enigmatic disease with a degree of etiologic heterogeneity. A number of variants can be defined clinically, and these include the syndromic group (typically BA splenic malformation), cystic BA, and cytomegalovirus (CMV) IgM +ve associated BA. The remainder, and still the largest group, ...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1053/j.sempedsurg.2012.05.010

    authors: Davenport M

    更新日期:2012-08-01 00:00:00

  • Pathology of inflammatory bowel disease.

    abstract::Inflammatory bowel disease in childhood refers to ulcerative colitis, Crohn's disease, and colitis of an indeterminate type. Their gross and microscopic features are discussed along with the differential diagnosis from other childhood conditions associated with bloody diarrhea. ...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1053/j.sempedsurg.2007.04.005

    authors: Gramlich T,Petras RE

    更新日期:2007-08-01 00:00:00

  • Contemporary interventional procedures for vascular disorders in children.

    abstract::Pediatric interventional radiology offers new treatment options not possible a few years ago. Interventional radiologists treat not only certain causes of hemorrhage but also symptomatic arteriovenous malformations, renovascular hypertension, and portal hypertension. Interventionalists help maintain liver and renal tr...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:

    authors: Iglesia KA,Fellows KE

    更新日期:1994-05-01 00:00:00

  • Fetal obstructive uropathy.

    abstract::Congenital obstructive uropathy is a relatively common developmental malformation, and severely affected fetuses die soon after birth from oligohydramnios-induced pulmonary hypoplasia or renal failure. Prenatal ultrasonography can reliably diagnose the specific anatomic defect, and using fetal urine sampling we can de...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:

    authors: Estes JM,Harrison MR

    更新日期:1993-05-01 00:00:00

  • Fetal surgery for spina bifida: past, present, future.

    abstract::Open spina bifida or myelomeningocele (MMC) is a common birth defect that is associated with significant lifelong morbidity. Little progress has been made in the postnatal surgical management of the child with spina bifida. Postnatal surgery is aimed at covering the exposed spinal cord, preventing infection, and treat...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1053/j.sempedsurg.2012.10.003

    authors: Adzick NS

    更新日期:2013-02-01 00:00:00

  • Surgical diversion of enterohepatic circulation in pediatric cholestasis.

    abstract::Progressive familial intrahepatic cholestasis (PFIC) and Alagille syndrome (AS) are conditions caused by either an autosomal recessive or an autosomal dominant genetic defect, and they are both characterized by cholestasis, jaundice, and severe debilitating pruritus refractory to medical management. Before the advent ...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.sempedsurg.2020.150946

    authors: Lemoine C,Superina R

    更新日期:2020-08-01 00:00:00

  • Long-term outcomes of pediatric intestinal failure.

    abstract::Management of pediatric intestinal failure has evolved in recent decades, with improved survival since the advent of specialized multidisciplinary intestinal failure centers. Though sepsis and intestinal failure associated liver disease still contribute to mortality, we now have growing data on the long-term outcomes ...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1053/j.sempedsurg.2017.09.006

    authors: Fullerton BS,Hong CR,Jaksic T

    更新日期:2017-10-01 00:00:00

  • Gene transfer to the tracheobronchial tree: implications for fetal gene therapy for cystic fibrosis.

    abstract::Gene transfer to the tracheobronchial tree has been an active area of investigation since the discovery of the genetic defect in the cystic fibrosis transmembrane conductance regulator over two decades ago. Cystic fibrosis (CF) is the most common lethal monogeneic disorder for which there is no cure short of lung tran...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1053/j.sempedsurg.2003.09.007

    authors: Keswani SG,Crombleholme TM

    更新日期:2004-02-01 00:00:00

  • Genetics of congenital diaphragmatic hernia.

    abstract::Congenital diaphragmatic hernia (CDH) is a common structural birth defect that affects approximately 1 in 2500 live births. Although the exact etiology of most cases of CDH remains unknown, it is becoming increasingly clear that genetic factors play an important role in many cases of CDH. In this paper, we review crit...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1053/j.sempedsurg.2007.01.003

    authors: Scott DA

    更新日期:2007-05-01 00:00:00

  • Insights into medical management of pediatric intestinal failure.

    abstract::Medical management of children with Intestinal failure continues to evolve. The development of specialized teams focused on the management of these children has made the most significant impact in improving outcomes. Medical management strategies are centered on the provision of adequate fluid electrolytes and calorie...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1053/j.sempedsurg.2018.07.006

    authors: Oliveira SB,Cole CR

    更新日期:2018-08-01 00:00:00

  • Adhesive small bowel obstruction--acute management and treatment in children.

    abstract::Adhesive small bowel obstruction is a significant cause of short- and long-term morbidity in infants and children. Unfortunately, the majority of scientific literature relative to adhesive obstructions continues to be dominated by adult studies. In this article, the existing literature for infant and pediatric adhesiv...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1053/j.sempedsurg.2014.06.006

    authors: Lautz TB,Barsness KA

    更新日期:2014-12-01 00:00:00

  • New tools in the treatment of motility disorders in children.

    abstract::Gastrointestinal motility disorders can develop in neurologically impaired children and those with congenital malformations of the gut. It is characterized by moderate to severe abdominal pain, vomiting, and failure to thrive. Antral dysmotility after fundoplication and increased sympathetic over activity are 2 factor...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1053/j.sempedsurg.2009.07.009

    authors: Carachi R,Currie JM,Steven M

    更新日期:2009-11-01 00:00:00

  • Laparoscopic splenectomy.

    abstract::Splenectomy in childhood usually is required for hematologic disorders such as hereditary spherocytosis, immune thrombocytopenic purpura, or sickle cell disease. The laparoscopic approach for splenectomy in children has been developed and advanced over the past 5 years. New techniques and equipment allow the procedure...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1016/s1055-8586(98)70032-0

    authors: Rescorla FJ

    更新日期:1998-11-01 00:00:00

  • Investigation in vomiting children.

    abstract::This article discusses how to investigate various surgical causes of vomiting. Particular emphasis is placed on plain radiographic, ultrasound, and contrast study findings. The article touches upon nineteen different diseases, and encompasses diseases found in neonates to adolescents. ...

    journal_title:Seminars in pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1053/j.sempedsurg.2003.08.002

    authors: Maclennan AC

    更新日期:2003-11-01 00:00:00