Necrotizing enterocolitis: Pathophysiology from a historical context.

Abstract:

:Necrotizing enterocolitis (NEC) continues to afflict approximately 7% of preterm infants born weighing less than 1500g, though recent investigations have provided novel insights into the pathogenesis of this complex disease. The disease has been a major cause of morbidity and mortality in neonatal intensive care units worldwide for many years, and our current understanding reflects exceptional observations made decades ago. In this review, we will describe NEC from a historical context and summarize seminal findings that underscore the importance of enteral feeding, the gut microbiota, and intestinal inflammation in this complex pathophysiology.

journal_name

Semin Pediatr Surg

authors

Hackam D,Caplan M

doi

10.1053/j.sempedsurg.2017.11.003

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

11-18

issue

1

eissn

1055-8586

issn

1532-9453

pii

S1055-8586(17)30136-1

journal_volume

27

pub_type

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