Abstract：
:Neuroblastoma is a heterogenous disease, with solid tumors arising in the adrenal gland or paraspinal regions in young children. Neuroblastoma is unique, with varied presentation and prognosis based on primary location and tumor stage. Tumor behavior and response to treatment ranges from spontaneous regression to disseminated, lethal disease depending on the individual biology of a patient's tumor. Stratification of the disease has changed, with patients now placed in low, intermediate, and high-risk categories depending on age, stage, and tumor biology. Long-term survival for the high-risk subset of patients with metastatic disease is <40% despite aggressive multimodal therapy. Derived from sympathoadrenal cells of the adrenal medulla and sympathetic nervous system, both malignant neuroblastoma and differentiated tumors have specialized norepinephrine transporter (NET) receptors which are naturally occurring in the sympathetic nervous system throughout the body. Metaiodobenzylguanidine (MIBG) is a norepinephrine analog that undergoes active uptake by NET receptors resulting in accumulation in neuroblastoma as well as tissues normally expressing the NET receptor. When radioiodine labeled, MIBG can be used for both diagnosis and treatment. This article describes the history of MIBG use in neuroblastoma, including its utility as an imaging modality for diagnosis as well as the varied ways in which is it included in the multimodal treatment algorithm.
journal_name
Semin Pediatr Surgjournal_title
Seminars in pediatric surgeryauthors
Olecki E,Grant CNdoi
10.1016/j.sempedsurg.2019.150859subject
Has Abstractpub_date
2019-12-01 00:00:00pages
150859issue
6eissn
1055-8586issn
1532-9453pii
S1055-8586(19)30117-9journal_volume
28pub_type
杂志文章,评审abstract：:Enhanced recovery after surgery (ERAS) has evolved over the past two decades. Originally aimed to standardize care among adults undergoing colorectal surgery, the tenets that developed have since been broadly accepted by a large number of adult surgical subspecialties, including bariatric surgery. This multidisciplina...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sempedsurg.2020.150885
更新日期：2020-02-01 00:00:00
abstract：:Prune belly is a lax, wrinkled abdominal wall and frequently is associated with other anomalies. The prune belly syndrome is a specific constellation of anomalies consisting of an abdominal wall deficient in muscular tissue, dilated urinary tract, and bilateral cryptorchidism. This group of anomalies is also called th...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：10.1053/spsu.2000.7556
更新日期：2000-08-01 00:00:00
abstract：:Congenital obstructive uropathy is a relatively common developmental malformation, and severely affected fetuses die soon after birth from oligohydramnios-induced pulmonary hypoplasia or renal failure. Prenatal ultrasonography can reliably diagnose the specific anatomic defect, and using fetal urine sampling we can de...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：
更新日期：1993-05-01 00:00:00
abstract：:Although the Worldwide Web has just blossomed this past decade, the origins of the Internet date to the late 1950s and Cold War concerns. The technological underpinning of the Internet rests with the concept of packet switching of data over dispersed routes of electronic intercommunication. Grounded in applications fo...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章
doi：10.1016/s1055-8586(00)70002-3
更新日期：2000-02-01 00:00:00
abstract：:Colorectal disease profiles for children in low- and middle-income settings (LMIC) are characterized by late presentation, increased complications and limited follow-up in many cases. There is a high prevalence of infectious conditions causing secondary colorectal disease such as Mycobacterium Tuberculosis(TB), Human ...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章
doi：10.1016/j.sempedsurg.2020.150989
更新日期：2020-12-01 00:00:00
abstract：:Congenital diaphragmatic hernia (CDH) is a congenital anomaly consisting of a posterolateral defect in the diaphragm also known as a Bochdalek hernia. It occurs in 1 in 2000 to 3000 newborns and is associated with a variable degree of pulmonary hypoplasia (PH) and persistent pulmonary hypertension (PPH). Despite remar...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：10.1053/j.sempedsurg.2010.03.001
更新日期：2010-08-01 00:00:00
abstract：:Adult and pediatric urologists, gynecologists, and surgeons are often faced with primary reconstruction of complex congenital defects of the vagina as seen in cloacal anomalies, disorders of sexual development (DSD), and vaginal agenesis as well as with the secondary repair of post-surgical or radiation-induced vagina...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章
doi：10.1016/j.sempedsurg.2019.150843
更新日期：2019-10-01 00:00:00
abstract：:Obesity affects 50% of adults and 18% of children in the USA. It has wide-ranging comorbidities with clinical, psychosocial, and economic ramifications. Obesity refers to a condition of excess body fat. The basis for weight gain is a fundamental imbalance between caloric intake and output, but individual variation bas...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章
doi：10.1053/j.sempedsurg.2009.04.008
更新日期：2009-08-01 00:00:00
abstract：:The outcome for children with congenital enteropathies or massive surgical resections has improved significantly over the past two decades. Advances in understanding of the pathophysiology of intractable diarrhea and of the mutations causing many of the congenital enteropathies have enabled initiation of preventive me...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：10.1053/j.sempedsurg.2009.11.003
更新日期：2010-02-01 00:00:00
abstract：:Increased portal pressure is the product of both increased resistance to splanchnic flow through the liver and increased blood flow in the portal circuit. Although portal hypertension in children is less common than in adults, the important clinical end results are the same, ie, esophageal variceal hemorrhage, ascites...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：
更新日期：1992-05-01 00:00:00
abstract：:The pediatric surgeon deals with a large number and variety of congenital defects in neonates that frequently involve early surgical intervention and care. Because the neonatal cardiac physiology is unique, starting with the transition from fetal circulation and including differences in calcium metabolism and myocardi...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：10.1053/j.sempedsurg.2013.10.004
更新日期：2013-11-01 00:00:00
abstract：:Traditional surgical attitude regarding error and complications has focused on individual failings. Human factors research has brought new and significant insights into the occurrence of error in healthcare, helping us identify systemic problems that injure patients while enhancing individual accountability and teamwo...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章
doi：10.1053/j.sempedsurg.2015.08.003
更新日期：2015-12-01 00:00:00
abstract：:Slipping rib syndrome (SRS) is an under-diagnosed cause of intermittent, yet often debilitating lower rib and abdominal pain. SRS is caused by a hypermobility of the anterior false ribs that allows the 8th-10th ribs to slip or click as the cartilaginous rib tip abuts or slips under the rib above. Pain occurs from impi...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：10.1053/j.sempedsurg.2018.05.009
更新日期：2018-06-01 00:00:00
abstract：:Pediatric interventional radiology offers new treatment options not possible a few years ago. Interventional radiologists treat not only certain causes of hemorrhage but also symptomatic arteriovenous malformations, renovascular hypertension, and portal hypertension. Interventionalists help maintain liver and renal tr...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：
更新日期：1994-05-01 00:00:00
abstract：:The neurologically or immunologically impaired child suspected of having an acute abdomen presents a formidable challenge. However, a thorough understanding of the underlying pathophysiology of the disease on the normal host response to an intraabdominal disease permits early recognition and initiation of treatment. C...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章
doi：
更新日期：1997-05-01 00:00:00
abstract：:The fallopian tubes are the essential genital ducts that convey the female sex cells for fertilization. They are differentiated and detectable early in fetal life. There are numerous paratubal and tubal abnormalities that can occur at any point in the female life. Some of these are rare but may initiate significant mo...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：10.1053/j.sempedsurg.2005.01.009
更新日期：2005-05-01 00:00:00
abstract：:Most children with short bowel syndrome experience spontaneous small bowel adaptation over time. This allows the majority to be weaned from parenteral nutrition. There are, however, some children who cannot be weaned and are potential candidates for techniques to promote intestinal adaptation and intestinal lengthenin...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：10.1053/spsu.2001.22855
更新日期：2001-05-01 00:00:00
abstract：:The increase in multiple gestation pregnancies has resulted in significant health care implications for both mother and child. Our ability to diagnose and intervene on an at-risk multi-gestation pregnancy has dramatically improved. It is important for the pediatric surgeon to be equipped with a basic fund of knowledge...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：10.1053/j.sempedsurg.2019.07.008
更新日期：2019-08-01 00:00:00
abstract：:The maintenance of long-term venous access is critical to the livelihood of children in a variety of clinical situations, especially those who are dependent on parenteral nutrition. Whereas the traditional routes of either peripheral or central venous access are initially adequate, most of these sites eventually succu...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：10.1016/s1055-8586(02)00024-0
更新日期：2003-05-01 00:00:00
abstract：:The practice of pediatric surgery is at the crossroads of 2 specialties, pediatrics and surgery. At that vantage point, many ethical dilemmas can be seen. It is important for the pediatric surgeon to understand the special place of ethics in the care of children and how that care is influenced by society. The purpose ...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：10.1053/spsu.2001.26837
更新日期：2001-11-01 00:00:00
abstract：:Recent advances in molecular biological techniques have increased our capability to distinguish the small differences in gene expression between subpopulations of cells found within specific tissues or tumor isolates. We use subtractive hybridization or subtractive cloning to generate information regarding genes that ...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：
更新日期：1996-08-01 00:00:00
abstract：:Neonatal surgery is recognized as an independent discipline in general surgery, requiring the expertise of pediatric surgeons to optimize outcomes in infants with surgical conditions. Survival following neonatal surgery has improved dramatically in the past 60 years. Improvements in pediatric surgical outcomes are in ...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：10.1053/j.sempedsurg.2016.10.005
更新日期：2016-12-01 00:00:00
abstract：:Appendectomy has been the standard of care for appendicitis since the late 1800s, and remains one of the most common operations performed in children. The advent of data-driven medicine has led to questions about every aspect of the operation-whether appendectomy is even necessary, when it should be performed (timing)...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：10.1053/j.sempedsurg.2016.05.003
更新日期：2016-08-01 00:00:00
abstract：:This article is designed to help the nonradiologist to form a logical imaging plan when presented with a diagnostic dilemma involving the pelvis of a young female. Common presenting problems are grouped under the categories of fetus, neonate and infant, child, and adolescent. Ultrasound is frequently the initial, and ...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：10.1016/s1055-8586(98)70008-3
更新日期：1998-02-01 00:00:00
abstract：:Pediatric heart transplantation has undergone major changes over the past two decades, marked by a substantial improvement in survival, reduction in posttransplant complications, and enhancement in quality of life for transplant recipients. Actuarial survival has improved substantially in the last decade. Indications ...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：10.1053/j.sempedsurg.2006.03.011
更新日期：2006-08-01 00:00:00
abstract：:The use of laparoscopic and thoracoscopic procedures in children continues to increase. Thus, anesthesiologists are faced with an increasing number of children for whom anesthetic care is required during these procedures. Significant physiological alterations may occur that are related to patient positioning and the i...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：
更新日期：1993-08-01 00:00:00
abstract：:The spectrum of complications associated with congenital lung malformation is wide. They can range from fetal hydrops in utero to postnatal problems of ventilation, obstruction and infection; presentation may occur from the neonatal period to adulthood. Many lesions will remain asymptomatic while at the other end of t...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：10.1053/j.sempedsurg.2015.02.002
更新日期：2015-08-01 00:00:00
abstract：:Management strategies for infants with very low birth weight (VLBW) who have abdominal wall defects essentially are the same as for those in larger infants. The authors favor primary closure in infants with gastroschisis, and have achieved this goal in 91% of infants since 1985. Treatment of infants with omphalocele i...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章
doi：10.1016/s1055-8586(00)70022-9
更新日期：2000-05-01 00:00:00
abstract：:Blunt cerebrovascular injury in children is an uncommon occurrence that if missed and left untreated can result in devastating long-term neurologic consequences. Diagnosis can be readily obtained by a computed tomographic angiogram of the head and neck. If confirmed, treatment with antithrombotic therapy dramatically ...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：10.1053/j.sempedsurg.2017.01.003
更新日期：2017-02-01 00:00:00
abstract：:The pathogenesis of necrotizing enterocolitis (NEC) is poorly understood, but appears to be multifactorial and highly associated with immaturity of the gastrointestinal tract, colonization of the intestinal microbiota, and immature innate immune system. The goal of this review is to provide an overview of some of thes...
journal_title：Seminars in pediatric surgery
pub_type： 杂志文章,评审
doi：10.1053/j.sempedsurg.2005.05.001
更新日期：2005-08-01 00:00:00
