Abstract:
:Reported incidence rates of carcinoma in patients with achalasia and the prevalence of achalasia in patients with esophageal cancer vary widely in the literature. The prognosis of an "achalasia-carcinoma" is generally considered poor, although systematic studies assessing the incidence, prevalence, and prognosis of patients with "achalasia-carcinoma" are scant. We investigated the incidence of esophageal cancer in a large series of patients with known achalasia, assessed the prevalence of achalasia in patients presenting with esophageal cancer, and evaluated the prognosis of these patients compared to that of patients with esophageal cancer without achalasia. Between 1982 and 1998 a total of 124 patients with primary achalasia were treated and followed at our department. During the same time period 1366 patients presented with esophageal cancer (879 esophageal squamous cell carcinomas, 487 adenocarcinomas). Of the 124 patients with primary achalasia, 4 developed a carcinoma during a mean follow-up of 5.6 years (i.e., an incidence of one carcinoma per 173.6 patient-years of follow-up). Altogether, 13 of 879 patients (1.5%) presenting with esophageal squamous cell carcinoma and 1 of 487 patients (0.2%), presenting with esophageal adenocarcinoma had a history of primary achalasia. Seven patients with achalasia-carcinoma (50%) had early-stage disease (stage I, IIA, or IIB). There was no difference in the prognosis of patients with resected achalasia-carcinoma versus those with esophageal carcinoma but no achalasia. Thus in our population of patients with long-standing achalasia the risk for developing an esophageal cancer was increased about 140-fold over that of the general population. With liberal use of surveillance, carcinoma could often be detected at an early stage in these patients, with a prognosis that was not worse than that of patients with squamous cell esophageal cancer but no achalasia.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Brücher BL,Stein HJ,Bartels H,Feussner H,Siewert JRdoi
10.1007/s00268-001-0026-3keywords:
subject
Has Abstractpub_date
2001-06-01 00:00:00pages
745-9issue
6eissn
0364-2313issn
1432-2323journal_volume
25pub_type
杂志文章abstract:BACKGROUND:This study was designed to asses the predictive factors of postoperative complications in patients who underwent a laparoscopic elective approach for recurrent diverticulitis and to determine the relationship between the number of acute episodes and surgical morbidity. METHODS:A retrospective analysis was p...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-0162-8
更新日期:2009-11-01 00:00:00
abstract:INTRODUCTION:Von Hippel-Lindau disease (VHL) is a dominantly inherited multi-system syndrome. Although pheochromocytoma is the hallmark endocrine neoplasm, pancreatic lesions occur frequently, and their management can be complex. This report describes 26 patients from a single institution with pancreatic or adrenal les...
journal_title:World journal of surgery
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abstract:BACKGROUND:Trauma is the third leading cause of death worldwide after cardiovascular and oncologic diseases. Predominant causes of trauma-related death (TD) are severe traumatic brain injury (sTBI), hemorrhagic shock, and multiple organ failure. An analysis of TD is required in order to review the quality of trauma car...
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doi:10.1007/s00268-019-05347-7
更新日期:2020-04-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章,已发布勘误
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更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Intestinal epithelial cell apoptosis has been reported in sepsis as a mechanism of organ failure. The aim of this study was to clarify the role of apoptosis-regulating proteins (bcl-2, bax, cytochrome-c, and caspase-8) in septic rats by studying their expression in gastric and intestinal epithelial cells. M...
journal_title:World journal of surgery
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abstract:BACKGROUND:Many patients who undergo emergency laparotomy are working, which is a key determinant for an individual's socio-economic status and financial security. The objectives of this study were to compare labour market participation and sick leave in a nationwide patient population undergoing non-malignant emergenc...
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abstract:BACKGROUND:Given surgery's inherent risks, a patient should be able to make the most informed decisions possible in selecting surgical treatment. However, there is little information on what factors patients deem important when choosing a surgeon. We performed a systematic review of the literature focused on how patien...
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pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:World journal of surgery
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-005-0076-z
更新日期:2005-12-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
abstract:: ...
journal_title:World journal of surgery
pub_type: 评论,信件
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF00295914
更新日期:1995-09-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-002-6654-4
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:Pancreatic cancer has higher concentrations of angiotensin II compared with other cancers. This study sought to assess the effect of angiotensin II receptor blockers (ARBs) on survival of patients undergoing resection using a large, nationally representative dataset. METHODS:Patients undergoing pancreatic c...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-017-4021-8
更新日期:2017-09-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900118
更新日期:1996-09-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-007-9286-x
更新日期:2008-01-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-012-1629-6
更新日期:2012-09-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-003-7010-z
更新日期:2003-12-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF00353738
更新日期:1994-07-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-020-05912-5
更新日期:2021-01-13 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-010-0493-5
更新日期:2010-07-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-010-0648-4
更新日期:2010-10-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-013-1959-z
更新日期:2013-05-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-020-05708-7
更新日期:2020-11-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章,评审
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更新日期:2000-10-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
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更新日期:2013-02-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-020-05495-1
更新日期:2020-07-01 00:00:00
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journal_title:World journal of surgery
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1997-01-01 00:00:00