Abstract:
AIM:To examine the effects of calcium hydroxide (Ca(OH)2), transforming growth factor-beta (TGF-beta 1), and Ca(OH)2/TGF-beta 1 coadministration on TGF-beta 1 and interleukin-6 (IL-6) synthesis by early (subculture 1) and late (subculture 5) osteoblast cultures. METHODOLOGY:Early and late cultures were established using bone cells harvested from 21-day-old fetal rat calvaria. Cell cultures of both early and late osteoblasts were divided into four groups: group 1, control; group 2, cells challenged with Ca(OH)2; group 3, cells challenged with TGF-beta 1; and group 4, cells challenged with Ca(OH)2 and TGF-beta 1 in combination. TGF-beta 1 and IL-6 levels for all groups were determined using ELISA methodology. RESULTS:ANOVA and Tukey HS analyses revealed that osteoblasts of groups 3 and 4 significantly increased (P < 0.001) TGF-beta 1 synthesis in both early and late cultures of osteoblasts. IL-6 was not detected in any of the groups considered in this study. CONCLUSIONS:Exogenous TGF-beta 1 has an autocrine effect on cell cultures of osteoblasts. Administration of TGF-beta 1 alone or in combination with Ca(OH)2 increases the synthesis of TGF-beta 1 in osteoblast cultures. Ca(OH)2 and TGF-beta 1 are compatible when placed in a culture of osteoblasts. Ca(OH)2 provides a favourable environment for the anabolic effects of TGF-beta 1.
journal_name
Int Endod Jjournal_title
International endodontic journalauthors
Jaunberzins A,Gutmann JL,Witherspoon DE,Harper RPdoi
10.1046/j.1365-2591.2000.00326.xkeywords:
subject
Has Abstractpub_date
2000-09-01 00:00:00pages
421-6issue
5eissn
0143-2885issn
1365-2591journal_volume
33pub_type
杂志文章abstract::The purpose of this study was to observe the quality of seal of the glass ionomer cement, Ketac-Endo, after treatment of the root canal wall. The root canals of 140 extracted human teeth were prepared biomechanically. The root canals were treated with either EDTA or received an intracanal dressing of calcium hydroxide...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.1995.tb00298.x
更新日期:1995-07-01 00:00:00
abstract:AIM:To compare the efficacy of different solutions (1% sodium hypochlorite, 10% citric acid and 20% EDTA) in the removal of calcium hydroxide from root canals. METHODOLOGY:One hundred single-rooted maxillary incisors were prepared to size 50 and split longitudinally. Two standardized grooves were cut into the apical a...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2010.01709.x
更新日期:2010-06-01 00:00:00
abstract:AIM:The aim of this study was to determine the percentage of anatomical canal configurations of the mesiobuccal root of the maxillary first molar in Japanese patients. METHODOLOGY:Three hundred teeth were obtained from general dentists who knew absolutely that they were extracted from Japanese patients. The distobucca...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1046/j.1365-2591.1999.00186.x
更新日期:1999-03-01 00:00:00
abstract:AIM:To evaluate the accuracy of the Root ZX and Elements-Diagnostic electronic apex locators when compared with radiographs for locating the canal terminus or minor foramen. METHODOLOGY:The canal terminus of 482 canals in 160 maxillary and mandibular teeth was located in vivo with both locators and radiographically. A...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2009.01620.x
更新日期:2010-01-01 00:00:00
abstract:AIM:To evaluate the neurotoxic effects of two endodontic sealers, AH-26 and Roth 801, on firing excitability and action potential configuration of F1 neural cells in the suboesophageal ganglia of Helix aspersa. METHODOLOGY:A conventional intracellular current clamp technique was used to study the blocking effects of A...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2003.00751.x
更新日期:2003-12-01 00:00:00
abstract::The purpose of this study was to compare the dentine-removing characteristics of size 25 K-files activated by the Cavi-Endo and Piezon-Endo units. The influence of power-setting, direction of file oscillation, interfacial force and operator-assisted movement were studied. Filing was performed on flat surfaces of denti...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.1993.tb00539.x
更新日期:1993-01-01 00:00:00
abstract::The effect on coronal leakage of the use of either a single gutta-percha cone or cold lateral condensation of gutta-percha, with a glass ionomer sealer cement was studied. In addition, the effect of the removal of the smear layer was also determined. Eighty-eight single-rooted teeth were prepared chemomechanically usi...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.1994.tb00255.x
更新日期:1994-07-01 00:00:00
abstract:AIM:To assess the impact of motion artefacts and motion-artefact correction on diagnostic accuracy of apical periodontitis (AP) in CBCT images. METHODOLOGY:Based on clinical and radiographic inspection of 40 formalin-fixated human jaw specimens, 77 roots in 45 teeth (molars and premolars), with various disease and tre...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.13326
更新日期:2020-09-01 00:00:00
abstract::This European Society of Endodontology (ESE) position statement on surgical extrusion, intentional replantation and tooth autotransplantation represents the consensus of an expert committee, convened by the ESE. A narrative review in the International Endodontic Journal (Plotino et al. 2020, international Endodontic J...
journal_title:International endodontic journal
pub_type: 杂志文章,评审
doi:10.1111/iej.13456
更新日期:2021-01-26 00:00:00
abstract:AIM:To assess the effectiveness of an active application of liquid etching, compared with the standard gel formulation on smear layer removal from post space walls and push-out bond strength of luted fibre posts. METHODOLOGY:Human extracted teeth were collected and root filled. After post space preparation and cleanin...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.12096
更新日期:2013-11-01 00:00:00
abstract:AIM:To present a scientometric analysis of the entire body of scientific publications in the field of vital pulp therapy (VPT) and analyse the research trends and popular topics. METHODOLOGY:A comprehensive literature search was conducted in the Web of Science and Scopus databases on 21 August 2020 to identify all art...
journal_title:International endodontic journal
pub_type: 杂志文章,评审
doi:10.1111/iej.13422
更新日期:2021-02-01 00:00:00
abstract:AIM:To evaluate lymphocyte-like cell activation (CD5-positive cells) and the expression of interleukin (IL)-6 and IL-17 in the pulp after tooth bleaching with two concentrations of hydrogen peroxide (H2 O2 ). METHODOLOGY:The right and left maxillary molars from 40 rats were treated randomly with bleaching gel with 20%...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.12891
更新日期:2018-07-01 00:00:00
abstract:AIM:To evaluate the apical extrusion of debris associated with several root canal preparation systems in vitro. METHODOLOGY:Forty-five extracted human mandibular premolars with single canals and similar lengths were used. The root canals were instrumented using ProTaper Next (Dentsply Maillefer, Ballaigues, Switzerlan...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.12369
更新日期:2015-07-01 00:00:00
abstract:AIM:To evaluate connective tissue reactions to iRoot SP (Innovative Bioceramics, Vancouver, BC, Canada), mineral trioxide aggregate (MTA) Fillapex (FLPX) (Angelus Soluções Odontológicas, Londrina, Brazil), DiaRoot Bioaggregate (DiaDent Group International, Burnaby, BC, Canada) and white MTA (Angelus, Londrina, Brazil) ...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.12203
更新日期:2014-07-01 00:00:00
abstract:AIM:To compare the push-out bond strength exhibited by root fillings performed with either C-Point and Endosequence® BC sealer™ (BC Sealer) or gutta-percha and AH Plus® after the instrumentation of oval canals with either the Self-Adjusting File (SAF) System or WaveOne (WO) reciprocating file. METHODOLOGY:Eighty extra...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.12455
更新日期:2016-04-01 00:00:00
abstract:AIM:To compare canal and isthmus debris debridement efficacies of the manual dynamic irrigation (MDI) and apical negative pressure (ANP) techniques in the mesial root of mandibular first molars with narrow isthmi, using a closed canal design. METHODOLOGY:Micro-computed tomography was employed to select 20 teeth, each ...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2010.01778.x
更新日期:2010-12-01 00:00:00
abstract:AIM:To identify, search for and critically interpret the results from clinical studies on single- versus multiple-visit root canal treatment in the light of an evidence-based paradigm. For that purpose, the quality of the available body of evidence was assessed using the SORT 'grade' - Strength of Recommendation Taxono...
journal_title:International endodontic journal
pub_type: 杂志文章,评审
doi:10.1111/iej.12621
更新日期:2017-03-01 00:00:00
abstract:AIM:To examine the role of stromal cell-derived factor 1 (SDF-1) signalling during odontogenic differentiation in human dental pulp cells (HDPCs). METHODOLOGY:Human dental pulp cells were treated with differentiation medium, recombinant human SDF-1, neutralizing antibody for SDF-1 or CXCR4, pertussis toxin (PTX) and A...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.12182
更新日期:2014-06-01 00:00:00
abstract:AIM:To examine plaque accumulation on silk and polyvinylidene fluoride (PVDF) sutures at different time intervals. METHODOLOGY:Twenty-one male albino rabbits received sutures under general and local anaesthesia. After 3, 5 and 7 days sutures were removed and processed for scanning electron microscope (SEM) observation...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2004.00873.x
更新日期:2004-11-01 00:00:00
abstract:AIM:To assay the toxicity of the single-methacrylate-based sealer urethane dimethacrylate (UDMA) (EndoRez) in terms of cell growth and pro-inflammatory cytokines release, in expanded ex vivo human dental pulp stem cells (hDPSCs), human periodontal ligament stem cells (hPDLSCs), human gingival fibroblasts (hGFs) and hum...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.12230
更新日期:2014-09-01 00:00:00
abstract:AIM:To evaluate the influence of delayed scanning on images obtained with two PSPs digital systems and on the diagnostic accuracy of vertical root fracture (VRF) by means of objective and subjective analyses. METHODOLOGY:Forty single-rooted human teeth were divided into two groups, one without VRFs and another with VR...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.12547
更新日期:2016-10-01 00:00:00
abstract:AIM:To evaluate the physical and mechanical properties of two cements with a similar chemical composition to mineral trioxide aggregate and to attempt to improve their properties by producing a composite material. METHODOLOGY:Two cement types were used: a mixture of calcium sulpho-aluminate cement and Portland cement ...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2008.01435.x
更新日期:2008-10-01 00:00:00
abstract::The aim of designing and fabricating the surgical templates was to assist the surgical component of premolar transplantation, by establishing and replicating the root dimensions of the donor premolar tooth. The correct template could be used to assess the socket preparation (width and depth) prior to placement of the ...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2012.02077.x
更新日期:2012-11-01 00:00:00
abstract:AIM:To evaluate the adhesive strength of Resilon to Next root canal sealant (Heraeus-Kulzer), a methacrylate-based root canal sealer, using a modified microshear bond testing design. METHODOLOGY:Flat Resilon surfaces of different roughnesses (smooth surface and surface roughness equivalent to 320-grit and 180-grit) we...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2005.01012.x
更新日期:2005-10-01 00:00:00
abstract:AIM:To compare the cyclic fatigue resistance of ProTaper Next files (PTN; Dentsply Maillefer, Ballaigues, Switzerland) with Twisted Files (TF; SybronEndo, Orange, CA, USA), HyFlex CM (HF; ColténeEndo/Whaledent, Inc, Cuyahoga Falls, OH, USA) and ProTaper Universal (PT; Dentsply Maillefer). METHODOLOGY:Size 25, .06 tape...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.12244
更新日期:2014-11-01 00:00:00
abstract:AIM:To investigate the role of the Ca(2+) -Mg(2+) ion channel TRPM7 in the proliferation, migration and osteogenic differentiation of human dental pulp stem cells (hDPSCs). METHODOLOGY:Immunohistochemistry was used to localize expression of TRPM7 in human dental pulp tissues and in cultured hDPSCs. Isolated hDPSCs wer...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.12193
更新日期:2014-06-01 00:00:00
abstract:AIM:To develop a suitable protocol for screening extracted teeth so as to create anatomically well-balanced experimental groups for endodontic studies. METHODOLOGY:Sixty pairs (120 teeth) of contralateral premolars (CLPs) were collected. The evaluation of samples for anatomical features was performed in the following ...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.12553
更新日期:2016-10-01 00:00:00
abstract:AIM:To quantify Substance P (SP) and Calcitonin gene-related peptide (CGRP) expression in healthy human periodontal ligament from premolars after root canal preparation with Reciproc Blue, WaveOne Gold, XP EndoShaper and hand files. METHODOLOGY:A total of 50 human periodontal ligament samples were obtained from health...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.12952
更新日期:2018-12-01 00:00:00
abstract::A light-cured ionomer cement was investigated as a retrograde root seal, without a retrograde cavity. This was compared with the material used in a retrograde cavity, and with a conventional glass ionomer cement, as a seal. The adaptation and sealing ability of the test materials were assessed using a confocal optical...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.1993.tb00562.x
更新日期:1993-07-01 00:00:00
abstract:AIM:The aim of this in vitro study was to evaluate the shear bond strength of commercially available and experimental glass ionomer cement (GIC) sealers to dentine exposed to common endodontic irrigants. METHODOLOGY:The enamel of 90 bovine incisor crowns, randomly divided into nine equal groups, was ground to expose t...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1046/j.1365-2591.1999.00238.x
更新日期:1999-11-01 00:00:00