Abstract：
:Telomerase adds hexameric repeats of 5'-TTAGGG-3' to the ends of chromosomal DNA (telomere) and has been implicated in cell immortalization and cellular senescence. The aim of this study was to measure quantitatively the telomerase activity and human telomerase RNA component (hTR) content in gastric cancer and to examine the relation between these values and histologic factors including Helicobacter pylori as a risk factor for gastric cancer. Telomerase activity was measured by a modified telomeric repeat amplification protocol in cancerous and noncancerous tissues (intestinal metaplasia, chronic gastritis, normal mucosa) from 27 gastric cancer patients; hTR expression was examined by the quantitative reverse transcriptase-polymerase chain reaction using fluorescent probes. Telomerase activity was higher in cancers (total product generated: 33.7) than in noncancerous tissues. Telomerase activity was higher in intestinal metaplasia (16.7) and chronic gastritis (10.6) than in normal mucosa (3.5). In patients with intestinal-type gastric cancer, telomerase activity was higher in intestinal metaplasia with H. pylori infection than in that without infection. hTR expression was not correlated with telomerase activity. H. pylori infection may influence telomerase activity in cancer and noncancerous tissues.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Kameshima H,Yagihashi A,Yajima T,Kobayashi D,Denno R,Hirata K,Watanabe Ndoi
10.1007/s002680010246keywords:
subject
Has Abstractpub_date
2000-10-01 00:00:00pages
1243-9issue
10eissn
0364-2313issn
1432-2323journal_volume
24pub_type
杂志文章abstract：BACKGROUND:The role of neutrophil-to-lymphocyte ratio (NLR) and preoperative prediction model in gastric cancer is controversial, while postoperative prognostic models are available. This study investigated NLR as a preoperative prognostic indicator in gastric cancer. METHODS:We reviewed patients with primary gastric ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4510-4
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:The appropriate surgical approach for hepatocellular carcinoma (HCC) patients of Child-Pugh class B is unclear. The aim of this study was to clarify the prognostic factors after hepatectomy in Child-Pugh class B patients and to delineate the selection criteria for hepatectomy. METHODS:One hundred fifty pati...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0929-y
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:A recent analysis found bradycardia during laparoscopy as a potential early warning sign of cardiac arrest. Knowledge regarding bradycardia frequency and its consequences during laparoscopy is limited. METHODS:Using the computerized record database, files of 9915 patients undergoing laparoscopic surgery, be...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-04935-x
更新日期：2019-06-01 00:00:00
abstract：:Treacher Collins Syndrome is a rare bilateral congenital deformity occurring in 1 in 10,000 births. It is also known, in the European literature, as Franceschetti Syndrome, and is additionally known as mandibulofacial dysostosis. It is a syndrome with a very wide spectrum of manifestations characterized by distortions...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01660753
更新日期：1989-07-01 00:00:00
abstract：:Frequently, several multiple abdominal reexplorations are needed in patients with acute necrotizing hemorrhagic pancreatitis (ANP) or with persistent intraabdominal sepsis (PIAS). Residual undrained necrotic and septic foci lead to multiple organ failure. To provide wide-open drainage of the abdominal cavity, since 19...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01658968
更新日期：1991-01-01 00:00:00
abstract：:The radiological features of common benign conditions of the breast and the radiological procedures used in the investigation of benign breast disorders are presented. ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01658415
更新日期：1989-11-01 00:00:00
abstract：BACKGROUND:Although various complications after hepatectomy have been reported, there have been no large studies on postoperative portal vein thrombosis (PVT) as a complication. This study evaluated the incidence, risk factors, and clinical outcomes of PVT after hepatectomy. METHODS:The preoperative and postoperative ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2440-8
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:The only potential cure for neuroendocrine tumors (NETs) is operative resection, which may also offer a survival benefit for advanced disease. We aimed to assess the role of 68Ga-DOTATATE PET/CT in preoperative planning and compared its performance to CT with IV contrast and MRI with Eovist®, for abdominal N...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05216-3
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Up to 50% of patients in intensive care units develop intraabdominal hypertension (IAH) in the course of medical treatment. If not detected on time and treated adequately, IAH may develop into an abdominal compartment syndrome (ACS) which is associated with a high mortality rate. Patients undergoing cardiac ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05917-0
更新日期：2021-01-22 00:00:00
abstract：BACKGROUND:Congenital diaphragmatic hernia (CDH) continues to be associated with significant mortality and morbidity rates despite advances in neonatal care. Fetal intervention for CDH has been studied for 25 years. After initial difficulties encountered with open fetal repair, attention has turned to tracheal occlusio...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9074-7
更新日期：2007-08-01 00:00:00
abstract：:Medical errors from communication failures are enormous during the perioperative period of cardiac surgical patients. As caregivers change shifts or surgical patients change location within the hospital, key information is lost or misconstrued. After a baseline cognitive study of information need and caregiver workflo...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0319-5
更新日期：2010-04-01 00:00:00
abstract：:We conducted a prospective case series study to investigate the causes of and factors influencing morbidity and mortality in 102 consecutive patients after elective infrarenal abdominal aneurysm (AAA) surgery between 1992 and 1995. Preoperative factors (demographics, risk factor indexes, electrocardiographic findings,...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900382
更新日期：1998-03-01 00:00:00
abstract：:This study aims to examine the frequency of the pheochromocytoma (pheo), defined as a "benign, intra-adrenal, hypertensive, sporadic, unilateral tumor." Three large series amounting to 310 subphrenic chromaffin tumors operated over periods of 17, 23, and 41 years, respectively, have been reviewed. Among those combined...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF00353738
更新日期：1994-07-01 00:00:00
abstract：BACKGROUND:Reported results of incisional hernia repair are poor with high recurrence rates unless prosthetic mesh is used. Mesh gives improved results, but certain techniques are associated with a high incidence of infections, fistulas, and seromas. This study reports the results of a consecutive series of incisional ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9118-z
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate the feasibility of liver resection in hepatocellular carcinoma (HCC) patients with preoperative renal dysfunction (RD). METHODS:Data from 735 patients undergoing primary liver resection for HCC between 2002 and 2014 were analyzed. Short- and long-term outcomes were comp...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4698-3
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:The recent development and spread of ultrasonography and ultrasonography-guided fine needle aspiration biopsy (FNAB) has facilitated the detection of small papillary microcarcinomas of the thyroid measuring 1 cm or less (PMC). The marked difference in prevalence between clinical thyroid carcinoma and PMC det...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0303-0
更新日期：2010-01-01 00:00:00
abstract：:We investigated the effect of radiofrequency ablation (RFA) of the liver on cell-mediated immunity in rats. Sprague-Dawley rats were divided into five groups: control group that did not have any procedure, a sham-operation group that underwent laparotomy, a lobectomy group that had left lateral lobectomy of the liver,...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-7728-x
更新日期：2005-06-01 00:00:00
abstract：:Although palpable axillary lymphadenopathy is most often related to benign disorders, it may be a harbinger of an underlying advanced malignancy. Fewer than 1% of patients diagnosed with breast cancer initially present with axillary metastases as their only clinical manifestation. This study represents the Mayo Clinic...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7290-y
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:The aim of the study was to compare the changes in health-related quality of life (QOL) after lung surgery between young and old patients. METHODS:We performed a prospective, population-based, cohort study to investigate health-related QOL before and 6 months after lung surgery. We used the validated instru...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0430-7
更新日期：2010-04-01 00:00:00
abstract：:The present study documents the indications and results of endoscopic sphincterotomy (ES) performed over 7 years in a surgical endoscopy unit. Potential improvement of results over this time period was analyzed. ES was associated with rare but undesirable morbidity and mortality. Specific improvement of results over t...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900195
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:There have been no reports on the impact of preoperative biliary MRSA infection on the outcome of major hepatectomy. The aim of this study was to review the surgical outcome of patients who underwent hepatobiliary resection after biliary drainage and to evaluate the impact of preoperative biliary MRSA infect...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-0990-1
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:The histone deacetylase (HDAC) inhibitors have emerged as the useful reagents that epigenetically modulate the expression of various genes. In the present study, the effects of HDAC inhibitors on the expression of inflammation-related genes and lung injury during sepsis were investigated. METHODS:Mice were ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0493-5
更新日期：2010-07-01 00:00:00
abstract：:Lower esophageal sphincter pressure has been assessed pre-operatively, intra-operatively,and more than 6 months postoperatively in 34 patients having antireflux surgery for gastro-esophageal reflux disease. The sphincter pressures associated with the outcome in relation to pH measured reflux and the symptoms of recurr...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF02071543
更新日期：1992-03-01 00:00:00
abstract：:Although HLA matching can improve organ graft survival, well matched grafts fail and poorly matched ones survive. Recently evidence has been found that perinatal exposure to noninherited antigens (NIMAs) has a lifelong impact on the immune repertoire of the individual. The state of the art of the influence of NIMAs on...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002680010132
更新日期：2000-07-01 00:00:00
abstract：:We reviewed our experience with 34 patients with metastatic endocrine tumors (METs) who were treated by different modalities. Eight patients were treated by chemotherapy or chemoembolization because of stable disease or surgical contraindications. Seventeen patients underwent curative or cytoreductive surgical resecti...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900138
更新日期：1996-09-01 00:00:00
abstract：:In a retrospective study the clinical course of 40 patients with symptomatic persistent or recurrent parathyroid cancer was analyzed in order to assess the value of aggressive surgical intervention. Recurrence was diagnosed after a median period of 33 months (1-228 months). Twenty-two patients had locoregional disease...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF00353773
更新日期：1994-07-01 00:00:00
abstract：BACKGROUND:LLR is widely adapted for HCC, while LLR in PS segments is still challenging. With recent improvement of techniques and accumulation of experiences, LLR in PS segments is feasible, but studies investigating the result after the modifications are lacking. METHODS:In this single-center, retrospective study, 1...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05912-5
更新日期：2021-01-13 00:00:00
abstract：INTRODUCTION:Despite formal definitions of mucinous cystic neoplasms (MCNs) and intraductal papillary neoplasms (IPMNs) by the World Health Organization (WHO) and Armed Forces Institute of Pathology (AFIP), several controversies with regard to MCNs remain. The aim of this review was to determine the clinicopathological...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-006-0126-1
更新日期：2006-12-01 00:00:00
abstract：INTRODUCTION:The association between socioeconomic status (SES) and relative survival of rectal cancer is little investigated. We hypothesized that the impact on risk of death by SES would be much smaller when differences in background mortality (comorbidity, lifestyle factors) were taken into account, i.e. in modellin...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2735-4
更新日期：2014-12-01 00:00:00
abstract：:The release of the neuronal protein S-100B into the circulation has been suggested as an early indication of cellular brain damage. The objective of this prospective pilot study was to determine S-100B serum levels in patients undergoing cross-clamping during carotid endarterectomy (CEA) and to correlate the results w...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6547-6
更新日期：2002-10-01 00:00:00
