[The influence of perinatal risk factors on the number of CD3+ lymphocytes and CD25+ cells in full-term neonates].

Abstract:

:In 39 full-term neonates aged from 1 to 7 days of life, among them 24 with perinatal risk factors and 15 healthy as the control group, immunophenotyping of CD3+ and CD25+ cells using Becton Dickinson flow cytometer and monoclonal antibodies and CD3+ and CD25+ was performed. It was stated, that the mean relative and absolute number of CD3+ T lymphocytes in high risk neonates did not differ from the mean values in control group. The premature rupture of fetal membranes in mothers caused a significant increase of mean relative number of CD3+, whereas it did not influence on the absolute number of these cells. Significant increase of mean relative and absolute number of CD25+ cells in neonates with perinatal risk factors in comparison with the control group was noted. Mean relative and absolute number of CD25+ cells were significantly higher in neonates with non-infectious risk factors than in neonates with infectious risk factors. Authors emphasize that, evaluation of CD25+ cells is useful in the assessment of immunological changes in high risk neonates.

journal_name

Ginekol Pol

journal_title

Ginekologia polska

authors

Ziecina-Krawiec B,Mazur B,Godula-Stuglik U,Stojewska M

keywords:

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

550-8

issue

6

eissn

0017-0011

issn

2543-6767

journal_volume

71

pub_type

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