Age-related changes in muscle.

Abstract:

:Sarcopenia is a debilitating condition that occurs with senescence. The present study places this entity in the context of life expectancy, then discusses the mechanism of muscle loss. The findings show deficits in muscle protein synthesis with advancing age and suggest that these deficits are specific to certain muscle protein components. Synthesis rates of myosin heavy chain and mitochondrial protein decline with advancing age; however, there are no specific conclusions as to causation of these reduced muscle protein syntheses. The utility of protein dynamic measurements in evaluating potential therapies is discussed.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Nair KS

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

S14-8

eissn

0025-6196

issn

1942-5546

journal_volume

75 Suppl

pub_type

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