Sarcoplasmic reticulum Ca(2+)ATPase and cell contraction in developing rabbit heart.

abstract：:Studies of hemodynamics and intrinsic left ventricular myocardial function are carried out to investigate the transition from stable hypertrophy to cardiac decompensation in the aging (18-24 months) spontaneously hypertensive rat (SHR). Echocardiographic data in awake animals demonstrate increased end-diastolic and en...

journal_title：Journal of molecular and cellular cardiology

authors： Bing OH,Brooks WW,Robinson KG,Slawsky MT,Hayes JA,Litwin SE,Sen S,Conrad CH

更新日期：1995-01-01 00:00:00

abstract：:Mild or low doses of oxidants are known to prime cells towards resistance against further damage. In cardiomyocytes, we found that pretreatment with 100 microM H(2)O(2) prevents the cells from apoptosis induced by doxorubicin (Dox). Affymetrix microarray analyses of 28,000 genes reveal that H(2)O(2) treated cells redu...

journal_title：Journal of molecular and cellular cardiology

authors： Purdom-Dickinson SE,Lin Y,Dedek M,Morrissy S,Johnson J,Chen QM

更新日期：2007-01-01 00:00:00

abstract：:The mechanisms responsible for myocardial dysfunction in the setting of sepsis remain undefined. Fas ligation with its cognate ligand (FasL) induces apoptosis and activates cellular inflammatory responses associated with tissue injury. We determined whether interruption of Fas/FasL interaction by cardiac-specific expr...

journal_title：Journal of molecular and cellular cardiology

authors： Niu J,Azfer A,Kolattukudy PE

更新日期：2008-01-01 00:00:00

abstract：:To understand better the pathophysiological roles of the vagal efferent system in ischemic heart diseases, we examined endogenous acetylcholine (ACh) release in the myocardium in vivo. Acute myocardial ischemia was induced in anesthetized cats by a 60-min occlusion of the left anterior descending coronary artery (LAD)...

journal_title：Journal of molecular and cellular cardiology

authors： Kawada T,Yamazaki T,Akiyama T,Sato T,Shishido T,Inagaki M,Takaki H,Sugimachi M,Sunagawa K

更新日期：2000-03-01 00:00:00

abstract：:The lack of pathological consequences of cardiac ATP-sensitive potassium channel (K(ATP)) channel gene manipulation is in stark contrast to the effect of similar perturbations in the pancreatic beta-cell. Because the pancreatic and cardiac channel share the same pore-forming subunit (Kir6.2), the different effects of ...

journal_title：Journal of molecular and cellular cardiology

authors： Flagg TP,Remedi MS,Masia R,Gomes J,McLerie M,Lopatin AN,Nichols CG

更新日期：2005-10-01 00:00:00

abstract：:Adaptive cardiac hypertrophy in the rat has been characterized as pathological or physiological reflecting the nature of the inciting stimulus. These two adaptations are distinguished by alterations in contractility and in the myosin ATPase composition of the affected muscle. We investigated the relative amounts of th...

journal_title：Journal of molecular and cellular cardiology

authors： Buttrick PM,Kaplan M,Leinwand LA,Scheuer J

更新日期：1994-01-01 00:00:00

abstract：:The progression of cardiomyopathy to congestive heart failure is often associated with the expression of fetal cardiac-specific genes. In mice, the basic helix-loop-helix transcription factors, dHAND and eHAND, are expressed in a cardiac chamber-specific fashion and are essential for fetal cardiac development, but are...

journal_title：Journal of molecular and cellular cardiology

authors： Natarajan A,Yamagishi H,Ahmad F,Li D,Roberts R,Matsuoka R,Hill S,Srivastava D

更新日期：2001-09-01 00:00:00

abstract：:Beta-adrenergic receptor kinase 1 (beta ARK1) participates in the desensitization of beta-adrenergic receptors by uncoupling the signal transduction. The present study was designed to examine whether neurohumoral increase is crucial for the activation of beta ARK1 in heart failure. Four weeks after the ligation of rat...

journal_title：Journal of molecular and cellular cardiology

authors： Ishigai Y,Mori T,Moriyama S,Shibano T

更新日期：1999-06-01 00:00:00

abstract：:The Ca(2+) dependent interaction between troponin I (cTnI) and troponin C (cTnC) triggers contraction in heart muscle. Heart failure is characterized by a decrease in cardiac output, and compounds that increase the sensitivity of cardiac muscle to Ca(2+) have therapeutic potential. The Ca(2+)-sensitizer, levosimendan,...

journal_title：Journal of molecular and cellular cardiology

authors： Robertson IM,Sun YB,Li MX,Sykes BD

更新日期：2010-12-01 00:00:00

abstract：:The sulfonylurea receptor SUR is an ATP binding cassette (ABC) protein of the ABCC/MRP family. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ATP-sensitive potassium (K(ATP)) channel. Within ...

journal_title：Journal of molecular and cellular cardiology

authors： Moreau C,Prost AL,Dérand R,Vivaudou M

更新日期：2005-06-01 00:00:00

abstract：:31P-NMR was used to monitor myocardial bioenergetics in compensated and failing SHHF/MCC-fa(cp) (SHF) rat hearts. The SHHF/Mcc-fa(cp) (spontaneous hypertension and heart failure) rat is a relatively new genetic model in which all individuals spontaneously develop congestive heart failure, most during the second year o...

journal_title：Journal of molecular and cellular cardiology

authors： Michael O'Donnell J,Narayan P,Bailey MQ,Abduljalil AM,Altschuld RA,McCune SA,Robitaille PM

更新日期：1998-02-01 00:00:00

abstract：:Myocardium which has been preconditioned by one or several brief episodes of ischemia has much slower energy utilization during a subsequent sustained episode of ischemia. Since preconditioned tissue also is 'stunned', the reduced energy utilization of preconditioned tissue may be due to reduced contractile effort. Th...

journal_title：Journal of molecular and cellular cardiology

authors： Jennings RB,Murry CE,Reimer KA

更新日期：1991-12-01 00:00:00

abstract：:Chronic pressure overload to the heart leads to cardiac hypertrophy and failure through processes that involve reorganization of subcellular compartments and alteration of established signaling mechanisms. To identify proteins contributing to this process, we examined changes in nuclear-associated myofilament proteins...

journal_title：Journal of molecular and cellular cardiology

authors： Paulsson AK,Franklin S,Mitchell-Jordan SA,Ren S,Wang Y,Vondriska TM

更新日期：2010-06-01 00:00:00

abstract：:Recently discovered endothelin is a powerful vasoconstrictor of vascular smooth muscle in vitro, which also profoundly affects the mechanical function of the heart. An increased level of plasma endothelin in patients with acute myocardial infarction suggests the enhanced release of endothelin from vascular endothelium...

journal_title：Journal of molecular and cellular cardiology

authors： Prasad MR,Jones RM,Kreutzer DL

更新日期：1991-06-01 00:00:00

abstract：:The cardiac voltage-gated Na(+) channel, Na(V)1.5, is responsible for the upstroke of the action potential in cardiomyocytes and for efficient propagation of the electrical impulse in the myocardium. Even subtle alterations of Na(V)1.5 function, as caused by mutations in its gene SCN5A, may lead to many different arrh...

journal_title：Journal of molecular and cellular cardiology

authors： Marionneau C,Abriel H

更新日期：2015-05-01 00:00:00

abstract：:Clinical studies suggest increased arrhythmia risk associated with cell therapy for myocardial infarction (MI); however, the underlying mechanisms are poorly understood. We hypothesize that the degree of electrical viability in the infarct and border zone associated with skeletal myoblast (SKMB) or mesenchymal stem ce...

journal_title：Journal of molecular and cellular cardiology

authors： Mills WR,Mal N,Kiedrowski MJ,Unger R,Forudi F,Popovic ZB,Penn MS,Laurita KR

更新日期：2007-02-01 00:00:00

abstract：:We compared myocardial mechanics and myosin isozymes of right and left ventricular papillary muscles from adult (6 to 8 month old) male rats. Analysis of force velocity relations indicate that right ventricular papillary muscles contract more rapidly than left at light loads (2.68 +/- 0.13 vs 2.18 +/- 0.07 muscle leng...

journal_title：Journal of molecular and cellular cardiology

authors： Brooks WW,Bing OH,Blaustein AS,Allen PD

更新日期：1987-05-01 00:00:00

abstract：:Studies to test whether superoxide dismutase (SOD), with or without catalase, limits myocardial infarct size have produced conflicting results. Positive results following short periods of reperfusion vs negative results following longer periods of reperfusion could be explained if either: (1) myocytes, initially salva...

journal_title：Journal of molecular and cellular cardiology

authors： Tanaka M,Richard VJ,Murry CE,Jennings RB,Reimer KA

更新日期：1993-04-01 00:00:00

abstract：:The incidence of ventricular arrhythmias is higher in failing hearts than in control hearts, especially during acute ischemia. Electrophysiological and extracellular ionic changes during acute ischemia in normal and failing rabbit myocardium were assessed. Heart failure was induced in rabbits by combined volume and pr...

journal_title：Journal of molecular and cellular cardiology

authors： Vermeulen JT,Tan HL,Rademaker H,Schumacher CA,Loh P,Opthof T,Coronel R,Janse MJ

更新日期：1996-01-01 00:00:00

abstract：:In mammalian myocardium, muscle contraction is regulated by the rapid release of Ca2+ ions through ryanodine-sensitive Ca2+ release channels present in the intracellular membrane compartment, sarcoplasmic reticulum (SR). In this study, the effects of regional ischemia on intrinsic SR Ca2+ release channel function were...

journal_title：Journal of molecular and cellular cardiology

authors： Darling EM,Lai FA,Meissner G

更新日期：1992-10-01 00:00:00

abstract：:Since angiotensin-converting enzyme (ACE) produces angiotensin II in the heart, ACE inhibitors may prevent coronary vasoconstriction and increase coronary blood flow. On the other hand, since ACE inhibitors also inhibit kininase II which results in reduced degradation of bradykinin, ACE inhibitors may increase cardiac...

journal_title：Journal of molecular and cellular cardiology

authors： Kitakaze M,Node K,Minamino T,Asanuma H,Ueda Y,Kosaka H,Kuzuya T,Hori M

更新日期：1998-11-01 00:00:00

abstract：:Diabetic cardiomyopathy has been documented as an underlying etiology of heart failure (HF) among diabetics. Although oxidative stress has been proposed to contribute to diabetic cardiomyopathy, much of the evidence lacks specificity. Furthermore, whether alterations occur at the cardiac proteome level in diabetic car...

journal_title：Journal of molecular and cellular cardiology

authors： Hamblin M,Friedman DB,Hill S,Caprioli RM,Smith HM,Hill MF

更新日期：2007-04-01 00:00:00

abstract：:Diabetic cardiomyopathy is responsible for substantial morbidity and mortality in the diabetic population. Increased oxidative stress has been associated with the pathogenesis of chronic diabetic complications including cardiomyopathy. Multiple biochemical mechanisms have been proposed to increase oxidative stress in ...

journal_title：Journal of molecular and cellular cardiology

authors： Farhangkhoee H,Khan ZA,Mukherjee S,Cukiernik M,Barbin YP,Karmazyn M,Chakrabarti S

更新日期：2003-12-01 00:00:00

abstract：:The electrophysiological heterogeneity that exists across the ventricular wall in the mammalian heart has long been recognized, but remains an area that is incompletely understood. Experimental studies of the mechanisms of arrhythmogenesis in the whole heart often examine the epicardial surface in isolation and thereb...

journal_title：Journal of molecular and cellular cardiology

authors： Di Diego JM,Sicouri S,Myles RC,Burton FL,Smith GL,Antzelevitch C

更新日期：2013-01-01 00:00:00

abstract：:Immediate post-receptor events following alpha-adrenoceptor stimulation in cardiac ventricular muscle are still largely unknown. Since membrane redox systems appear to be present in cell plasma membranes and may be involved in trans-sarcolemma electron efflux, the possibility that Ca2+ inflow was controlled by electro...

journal_title：Journal of molecular and cellular cardiology

authors： Clark MG,Rattigan S

更新日期：1986-11-01 00:00:00

abstract：:A newly developed method was used to make a direct study of the influence of lanthanum on the subcellular distribution of isotopic and elemental calcium in the isolated perfused dog heart. The trivalent cation was introduced into the heart for the last 5 min of a 60 min perfusion period. Developed pressure and dP/dt w...

journal_title：Journal of molecular and cellular cardiology

authors： Kolbeck RC,Speir WA Jr

更新日期：1986-07-01 00:00:00

abstract：:The importance of endogenous and exogenous estrogen levels to the development of cardiovascular disease in women in controversial. The purpose of our study was to examine the effect of estrogen on the development of hypertension, cardiac hypertrophy, ventricular function, and gene expression for atrial natriuretic pep...

journal_title：Journal of molecular and cellular cardiology

authors： Sharkey LC,Holycross BJ,Park S,Shiry LJ,Hoepf TM,McCune SA,Radin MJ

更新日期：1999-08-01 00:00:00

abstract：:Satellite cells from adult mouse tongue, diaphragm, vastus lateralis, rectus femoris, tibialis anterior, soleus, and extensor digitorum longus muscles were isolated, expanded, and differentiated under identical culture conditions. Proliferating myoblasts and differentiated myofiber cultures were analyzed via SDS-PAGE,...

journal_title：Journal of molecular and cellular cardiology

authors： LaFramboise WA,Guthrie RD,Scalise D,Elborne V,Bombach KL,Armanious CS,Magovern JA

更新日期：2003-10-01 00:00:00

abstract：:The effects of class I antiarrhythmic drugs (quinidine, lidocaine, ethmozin) on the maximum upstroke velocity (Vmax) of the action potential (AP) of guinea-pig papillary muscles were investigated in the presence and absence of nifedipine and a potassium-free solution. Nifedipine (10 microM) decreased AP duration from ...

journal_title：Journal of molecular and cellular cardiology

authors： Jurevicius J,Muckus K,Macianskiene R,Chmel-Dunaj GN

更新日期：1991-02-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in genes encoding sarcomere proteins. The mechanisms involved in the development of cardiac hypertrophy and heart failure remain poorly understood. Global proteomic profiling was used to study the cardiac proteome of mice predisposed to develo...

journal_title：Journal of molecular and cellular cardiology

authors： Lam L,Tsoutsman T,Arthur J,Semsarian C

更新日期：2010-05-01 00:00:00