当前位置： SCI文献检索 > JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY期刊下所有文献 > Induction of antioxidant and detoxification response by oxidants in cardiomyocytes: evidence from gene expression profiling and activation of Nrf2 transcription factor.

Induction of antioxidant and detoxification response by oxidants in cardiomyocytes: evidence from gene expression profiling and activation of Nrf2 transcription factor.

Abstract：

:Mild or low doses of oxidants are known to prime cells towards resistance against further damage. In cardiomyocytes, we found that pretreatment with 100 microM H(2)O(2) prevents the cells from apoptosis induced by doxorubicin (Dox). Affymetrix microarray analyses of 28,000 genes reveal that H(2)O(2) treated cells reduced expression of genes encoding cytochrome c, mitochondrial complex I, III, IV and V and several contractile proteins. Elevated expression of antioxidant and detoxification genes appears as a dominant feature of the gene expression profile of H(2)O(2) treated cells. Most of the genes in this category contain an Antioxidant Response Element (ARE) in their promoters. Measurements of ARE promoter-reporter gene activity indicate a dose- and time-dependent activation of the ARE by H(2)O(2). Since the Nrf2 transcription factor regulates ARE-mediated gene expression, we overexpressed Nrf2 to test whether activation of Nrf2 is sufficient to induce cytoprotection. High levels of Nrf2 expression were achieved via adenovirus mediated gene delivery. Transduced Nrf2 was present in the nuclei and caused an increase in the expression of NAD(P)H:quinone oxidoreductase 1 (NQO1), a representative downstream target of Nrf2. Unlike H(2)O(2) pretreated cells, the cells expressing high levels of Nrf2 were not resistant to Dox-induced apoptosis. Therefore, the cytoprotective effect of H(2)O(2) pretreatment is not reliant upon Nrf2 activation alone as measured by resistance against Dox-induced apoptosis.

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Purdom-Dickinson SE,Lin Y,Dedek M,Morrissy S,Johnson J,Chen QM

doi

10.1016/j.yjmcc.2006.09.012

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

159-76

issue

1

eissn

0022-2828

issn

1095-8584

pii

S0022-2828(06)00920-5

journal_volume

42

pub_type

杂志文章

相关文献

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY文献大全
  • SAG attenuates apoptotic cell death caused by simulated ischaemia/reoxygenation in rat cardiomyocytes.

    abstract：:Sensitive to apoptosis gene (SAG) is a novel RING finger protein that has been shown to be involved in protection against apoptotic cell death induced by oxidative stress in various cell types. As SAG has been previously shown to be expressed in the heart, we assessed its role in cardiac myocytes exposed to ischaemic ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(03)00003-8

    authors： Chanalaris A,Sun Y,Latchman DS,Stephanou A

    更新日期：2003-03-01 00:00:00

  • Effects of myosin heavy chain manipulation in experimental heart failure.

    abstract：:The myosin heavy chain (MHC) isoforms, alpha- and beta-MHC, are expressed in developmental- and chamber-specific patterns. Healthy human ventricle contains approximately 2-10% alpha-MHC and these levels are reduced even further in the failing ventricle. While down-regulation of alpha-MHC in failing myocardium is consi...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2009.10.013

    authors： James J,Hor K,Moga MA,Martin LA,Robbins J

    更新日期：2010-05-01 00:00:00

  • 'Calcium paradox' in the heart is modulated by cell sodium during the calcium-free period.

    abstract：:We hypothesized that after a Ca2+-free period the magnitude of the Na+ gradient at the onset of Ca2+ reperfusion would grade the ensuing cell Ca2+ gain. Rabbit interventricular septa perfused with Hepes buffered solution (pH 7.4, [Ca2+] = 1.0 mM) and stimulated to contract isometrically at 60 min-1 at 30 degrees C wer...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(84)80002-4

    authors： Ruaño-Arroyo G,Gerstenblith G,Lakatta EG

    更新日期：1984-09-01 00:00:00

  • Reduced expression of mitochondrial electron transport chain proteins from hibernating hearts relative to ischemic preconditioned hearts in the second window of protection.

    abstract：:Although protection against necrosis has been observed in both hibernating (HIB) and ischemic preconditioned hearts in the second window of protection (SWOP), a comparison of the mitochondrial proteome between the two entities has not been previously performed. Anesthetized swine underwent instrumentation with a fixed...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2013.03.018

    authors： Cabrera JA,Butterick TA,Long EK,Ziemba EA,Anderson LB,Duffy CM,Sluiter W,Duncker DJ,Zhang J,Chen Y,Ward HB,Kelly RF,McFalls EO

    更新日期：2013-07-01 00:00:00

  • Dose/response curves of lipoic acid R-and S-forms in the working rat heart during reoxygenation: superiority of the R-enantiomer in enhancement of aortic flow.

    abstract：:Micromolar concentrations of lipoic acid racemate added to a working rat heart during hypoxia have been previously found to improve aortic flow during subsequent reoxygenation. Since the R-form represents the naturally occurring form of lipoic acid, and the S-form does not reveal a positive influence on ATP synthesis ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(95)90012-8

    authors： Zimmer G,Beikler TK,Schneider M,Ibel J,Tritschler H,Ulrich H

    更新日期：1995-09-01 00:00:00

  • The calcium paradox phenomenon: a flow rate and volume response study of calcium-free perfusion.

    abstract：:A dose-response study concerning the importance of the flow rate (0.5 to 12 ml/min) and volume (2.5 to 60 ml) of calcium-free coronary perfusion (duration 5 min) in the induction of a calcium paradox on reperfusion (duration 15 min) with calcium-containing medium has been performed in the isolated rat heart (37 degree...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(85)80076-6

    authors： Oksendal AN,Jynge P,Sellevold OF,Rotevatn S,Saetersdal T

    更新日期：1985-10-01 00:00:00

  • Nitric oxide-dependent vasodilation maintains blood flow in true hibernating myocardium.

    abstract：:Patients with chronic coronary artery disease may exhibit chronically depressed regional myocardial function, which can be reversed by revascularization. This was called hibernating myocardium, since it was thought that myocardial blood flow was also chronically reduced and since animals during true hibernation are th...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(03)00174-3

    authors： Kudej RK,Vatner SF

    更新日期：2003-08-01 00:00:00

  • Dual effect of the heart-targeting cytokine cardiotrophin-1 on glucose transport in cardiomyocytes.

    abstract：:Cardiotrophin-1 (CT-1) is a heart-targeting cytokine that is increased in the metabolic syndrome due to overexpression in the adipocytes. The effects of CT-1 on cardiomyocyte substrate metabolism remain unknown. We therefore determined the effects of CT-1 on basal and stimulated glucose transport in cardiomyocytes exp...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2012.12.015

    authors： Asrih M,Gardier S,Papageorgiou I,Montessuit C

    更新日期：2013-03-01 00:00:00

  • Non-coding RNAs as modulators of the cardiac fibroblast phenotype.

    abstract：:Cardiac fibroblasts represent one of the most frequent cell type in the heart of rodents and humans and alterations of their phenotype have a great impact on cardiac function. Due to aging, ischemic injuries, valvular dysfunctions, hypertension and aortic stenosis, multiple signals trigger the accumulation of extracel...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2015.12.023

    authors： Piccoli MT,Bär C,Thum T

    更新日期：2016-03-01 00:00:00

  • Contractile responses of isolated adult rat and rabbit cardiac myocytes to isoproterenol and calcium.

    abstract：:Myocytes were isolated by Langendorff perfusion of rat or rabbit hearts with low calcium solution followed by collagenase and hyaluronidase, or by incubation of chunks of rat ventricular tissue in similar media. Cells were then placed in a bath on a microscope stage, superfused and electrically stimulated. Contraction...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(88)80121-4

    authors： Harding SE,Vescovo G,Kirby M,Jones SM,Gurden J,Poole-Wilson PA

    更新日期：1988-07-01 00:00:00

  • Control of intracellular ionized calcium concentration by sarcolemmal and intracellular mechanisms.

    abstract：:The regulation of the resting intracellular ionized calcium concentration [( Ca2+]i) has been studied in ferret papillary muscle using the photoprotein aequorin to measure [Ca2+]i. Elevating [Ca2+]o produced an initial rapid increase of [Ca2+]i and tension which then decayed to a steady level. This secondary fall of [...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(84)80702-6

    authors： Eisner DA,Orchard CH,Allen DG

    更新日期：1984-02-01 00:00:00

  • Myocardial adenosine formation during hypoxia: effects of ecto-5'-nucleotidase inhibition.

    abstract：:Release of adenosine and AMP into epicardial fluid and coronary venous effluent of isovolumic guinea-pig hearts was examined during normoxic (95% O2) and hypoxic (30% O2) perfusion with and without the ecto-5'-nucleotidase inhibitor alpha,beta-methylene adenosine diphosphate (AOPCP)*. Normoxic epicardial and venous ad...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(92)93166-h

    authors： Headrick JP,Matherne GP,Berne RM

    更新日期：1992-03-01 00:00:00

  • Homocysteine accelerates senescence and reduces proliferation of endothelial progenitor cells.

    abstract：:Our previous studies showed that homocysteine (Hcy) reduces endothelial progenitor cell (EPC) numbers and impairs functional activity. However, the mechanisms by which Hcy reduces EPCs numbers and activity remain to be determined. Recent studies have demonstrated that reduced EPCs numbers and activity was associated w...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2006.01.011

    authors： Zhu JH,Chen JZ,Wang XX,Xie XD,Sun J,Zhang FR

    更新日期：2006-05-01 00:00:00

  • Effect of muscle origin and phenotype on satellite cell muscle-specific gene expression.

    abstract：:Satellite cells from adult mouse tongue, diaphragm, vastus lateralis, rectus femoris, tibialis anterior, soleus, and extensor digitorum longus muscles were isolated, expanded, and differentiated under identical culture conditions. Proliferating myoblasts and differentiated myofiber cultures were analyzed via SDS-PAGE,...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(03)00245-1

    authors： LaFramboise WA,Guthrie RD,Scalise D,Elborne V,Bombach KL,Armanious CS,Magovern JA

    更新日期：2003-10-01 00:00:00

  • Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D.

    abstract：RATIONALE:How ischemic postconditioning can inhibit opening of the mitochondrial permeability transition pore (PTP) and subsequent cardiac myocytes death at reperfusion remains unknown. Recent studies have suggested that de-acetylation of cyclophilin D (CyPD) by sirtuin 3 (SIRT3) can modulate its binding to the PTP. O...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2015.03.017

    authors： Bochaton T,Crola-Da-Silva C,Pillot B,Villedieu C,Ferreras L,Alam MR,Thibault H,Strina M,Gharib A,Ovize M,Baetz D

    更新日期：2015-07-01 00:00:00

  • Extracellular signal-regulated kinase activation during cardiac hypertrophy reduces sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) transcription.

    abstract：:Pathologic cardiac hypertrophy can lead to heart failure, but the mechanisms involved are poorly understood. SERCA2 is critical for normal cardiac calcium handling and function and SERCA2 mRNA and protein levels are reduced by cardiac hypertrophy. We hypothesized that extracellular signal-regulated kinase (ERK) 1/2 ac...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2014.06.018

    authors： Huang H,Joseph LC,Gurin MI,Thorp EB,Morrow JP

    更新日期：2014-10-01 00:00:00

  • Angiotensin II potentiates DNA synthesis in AT-1 transformed cardiomyocytes.

    abstract：:Angiotensin II has been shown to be mitogenic in various cell types. In cultured neonatal cardiomyocytes, we have demonstrated that angiotensin II causes hypertrophy, not hyperplasia. However, fetal or neonatal cardiomyocytes exhibit limited proliferation in primary culture, and are mitotically less potent. In order t...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1998.0770

    authors： Fukuda K,Izumo S

    更新日期：1998-10-01 00:00:00

  • Age-related decrease in cardiac tolerance to oxidative stress.

    abstract：:Oxygen radical-mediated injury has been implicated in the process of cardiac aging. We investigated the tolerance to oxidative stress of hearts from rats of different age. Langendorff-perfused hearts from 3-12-month-old rats received a 30 min infusion of the reactive oxygen specie hydrogen peroxide (H2O2, 60 microM), ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1998.0862

    authors： Abete P,Napoli C,Santoro G,Ferrara N,Tritto I,Chiariello M,Rengo F,Ambrosio G

    更新日期：1999-01-01 00:00:00

  • Microtubules in the heart muscle of the postnatal and adult rat.

    abstract：:In the postnatal rat heart, muscle cells continue to divide as well as increase in size. At the same time the cells in the soleus muscle (a slow skeletal muscle) do not divide, although they continue to grow in size. Since microtubules may have a role in orienting intracellular structures in muscle, we determined the ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(85)80087-0

    authors： Cartwright J Jr,Goldstein MA

    更新日期：1985-01-01 00:00:00

  • Local control of β-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca(2+)-transient.

    abstract：:Local signaling domains and numerous interacting molecular pathways and substrates contribute to the whole-cell response of myocytes during β-adrenergic stimulation (βARS). We aimed to elucidate the quantitative contribution of substrates and their local signaling environments during βARS to the canine epicardial vent...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2011.02.007

    authors： Heijman J,Volders PG,Westra RL,Rudy Y

    更新日期：2011-05-01 00:00:00

  • Novel deletions in MYH7 and MYBPC3 identified in Indian families with familial hypertrophic cardiomyopathy.

    abstract：:Mutations causing familial hypertrophic cardiomyopathy (HCM) have been described in at least 11 genes encoding cardiac sarcomeric proteins. In this study, three previously unknown deletions have been identified in the human cardiac genes coding for beta-myosin heavy chain (MYH7 on chromosome 14) and myosin-binding pro...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(03)00050-6

    authors： Waldmüller S,Sakthivel S,Saadi AV,Selignow C,Rakesh PG,Golubenko M,Joseph PK,Padmakumar R,Richard P,Schwartz K,Tharakan JM,Rajamanickam C,Vosberg HP

    更新日期：2003-06-01 00:00:00

  • Expression of perlecan proteoglycan in the infarct zone of mouse myocardial infarction.

    abstract：:Perlecan, a basal lamina proteoglycan, has been shown to interact with other extracellular matrix (ECM) components, especially type IV collagen, and is thus involved in ECM formation. Perlecan has also been postulated to promote growth factor-receptor interactions, including the binding of basic fibroblast growth fact...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.2000.1146

    authors： Nakahama M,Murakami T,Kusachi S,Naito I,Takeda K,Ohnishi H,Komatsubara I,Oka T,Ninomiya Y,Tsuji T

    更新日期：2000-06-01 00:00:00

  • Comparative study on isolation and mitochondrial function of adult mouse and rat cardiomyocytes.

    abstract：BACKGROUND:Cultured adult mouse and rat cardiomyocytes are the best and low-cost cell model for cardiac cellular physiology, pathology, drug toxicity screening, and intervention. The functions of mouse cardiomyocytes decline faster than rat cardiomyocytes in culture conditions. However, little is known about the differ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2019.09.006

    authors： Liu B,Li A,Qin Y,Tian X,Gao M,Jiang W,Gong G

    更新日期：2019-11-01 00:00:00

  • Increased myocyte fragility following anoxic injury.

    abstract：:The ability of cells in anoxic-perfused hearts to withstand two types of physical stresses (stretching and swelling), in the absence of reoxygenation was determined. Isolated rat hearts were perfused for 20, 40, or 60 mins with anoxic buffer after which hearts were either reoxygenated for 20 mins or exposed for 15 s t...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(87)80353-x

    authors： Vander Heide RS,Ganote CE

    更新日期：1987-11-01 00:00:00

  • Contractile function of cardiomyocytes from the spontaneously hypertensive rat.

    abstract：:In essential hypertension it has been hypothesized that there is a generalized derangement in cellular Ca2+ homeostasis. The aim of this study was to assess whether there is functional evidence for increased vulnerability to Ca overload in cardiomyocytes derived from age-matched (11-week) normotensive Wistar-Kyoto (WK...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1996.0067

    authors： Delbridge LM,Connell PJ,Morgan TO,Harris PJ

    更新日期：1996-04-01 00:00:00

  • Development of novel method of non-viral efficient gene transfer into neonatal cardiac myocytes.

    abstract：:To establish new treatment for cardiovascular disease, the development of safe and highly efficient vectors is necessary. Especially, non-viral vectors are considered to be ideal for human gene therapy, since recent adverse events with retroviral or adenoviral vectors have highlighted the issue of safety. Although we ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2005.06.007

    authors： Tashiro H,Aoki M,Isobe M,Hashiya N,Makino H,Kaneda Y,Ogihara T,Morishita R

    更新日期：2005-09-01 00:00:00

  • Coronary vasodilation shifts the diastolic pressure-dimension curve of the left ventricle.

    abstract：:The volume of blood in the left ventricular wall increases as coronary perfusion pressure or coronary blood flow increase, but it is unclear whether such an increase in volume can acutely alter the diastolic pressure-dimension relationship of the intact, working left ventricle. In 19 dogs, we measured left ventricular...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(86)80966-x

    authors： Verrier ED,Bristow JD,Hoffman JI

    更新日期：1986-06-01 00:00:00

  • Myocardial DNA content, ploidy level and cell number in geriatric hearts: post-mortem examinations of human myocardium in old age.

    abstract：:A reduced adaptation rate of the myocardium must, in many cases, be made responsible for heart insufficiency of old patients. The present investigations are aimed towards the question whether heart in old age is accompanied by a loss of myocardial cells and whether a polyploidisation of heart muscle cells takes place ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(86)80981-6

    authors： Adler CP,Friedburg H

    更新日期：1986-01-01 00:00:00

  • Directed expression of dominant-negative p73 enables proliferation of cardiomyocytes in mice.

    abstract：:Previous studies have shown that p53 plays an important role in maintaining cell cycle arrest of cardiomyocytes, which might account for the inability of human hearts to regenerate adequately after injury. Therefore, inhibition of p53 represents an attractive strategy to restore cell cycle progression in cardiomyocyte...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2008.06.006

    authors： Ebelt H,Zhang Y,Köhler K,Xu J,Gajawada P,Boettger T,Hollemann T,Müller-Werdan U,Werdan K,Braun T

    更新日期：2008-09-01 00:00:00

  • Therapeutic targeting of autophagy in cardiovascular disease.

    abstract：:Autophagy is an evolutionarily ancient process of intracellular catabolism necessary to preserve cellular homeostasis in response to a wide variety of stresses. In the case of post-mitotic cells, where cell replacement is not an option, finely tuned quality control of cytoplasmic constituents and organelles is especia...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2015.11.019

    authors： Schiattarella GG,Hill JA

    更新日期：2016-06-01 00:00:00