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Non-coding RNAs as modulators of the cardiac fibroblast phenotype.

Abstract：

:Cardiac fibroblasts represent one of the most frequent cell type in the heart of rodents and humans and alterations of their phenotype have a great impact on cardiac function. Due to aging, ischemic injuries, valvular dysfunctions, hypertension and aortic stenosis, multiple signals trigger the accumulation of extracellular matrix in the cardiac interstitium and perivascular space, leading to structural and functional detrimental changes in the heart. Cardiac fibroblasts are the principal orchestrators of matrix formation and degradation and indirectly regulate cardiac hypertrophy and inflammation. Understanding the molecular bases of their action could provide tools for the treatment of cardiac remodeling. This review summarizes recent evidences on non-coding RNAs, including microRNAs and long non-coding RNAs that modulate the phenotype of cardiac fibroblasts and may serve in the future as targets for novel therapeutic strategies against cardiac fibrosis.

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Piccoli MT,Bär C,Thum T

doi

10.1016/j.yjmcc.2015.12.023

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

75-81

eissn

0022-2828

issn

1095-8584

pii

S0022-2828(15)30161-9

journal_volume

92

pub_type

杂志文章,评审

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