当前位置： SCI文献检索 > JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY期刊下所有文献 > Maturational differences in bioenergetic state and purine formation during "supply" and "demand" ischemia.

Maturational differences in bioenergetic state and purine formation during "supply" and "demand" ischemia.

Abstract：

:We examined metabolic effects of "supply" and "demand" ischemia in immature and mature rabbit hearts. Moderate supply ischemia was produced by a 50% reduction in coronary flow (to approximately 5.0 ml min-1 g-1 giving a 50-55% rise in O2 extraction and a 35% drop in O2 supply/demand). Demand ischemia was produced by stimulation of workload and O2 demand with 30 microM norepinephrine at constant coronary flow (55-60% rise in O2 extraction, 35-40% fall in O2 supply/demand). Basal energy state ([ATP]/[ADP].[Pi]) was lower in immature compared to mature hearts, primarily due to reduced [PCr]. Despite a lower energy state, basal purine efflux was lowest in immature hearts. During supply ischemia reductions in [ATP]/[ADP]. [Pi] and elevations in [H+] were greatest in mature compared to immature hearts (P < 0.05). Despite this depressed energy state purine efflux did not increase significantly during supply ischemia. In contrast, during demand ischemia reductions in energy state were greatest in immature compared to mature hearts. Moreover, purine efflux increased more than 30-fold in immature and only four-fold in mature hearts, resulting in two-fold greater purine washout in immature hearts. The data indicate that: (i) maturation increases basal energy state and, paradoxically, purine efflux, (ii) in immature hearts demand ischemia has a greater impact on energy state than supply ischemia, whereas there are minimal differences in the metabolic effects of supply and demand ischemia in mature hearts, (iii) consequently while maturation is associated with a reduction in metabolic/bioenergetic resistance to supply ischemia it is associated with increased resistance to demand ischemia, (iv) markedly reduced purine wash-out from mature myocardium may contribute to this increased resistance during demand ischemia, and (v) control of adenosine formation and purine efflux changes with maturation, and appears to involve mechanisms unrelated to cytosolic energy metabolism.

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Matherne GP,Ely SW,Headrick JP

doi

10.1006/jmcc.1996.0105

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

1143-55

issue

5

eissn

0022-2828

issn

1095-8584

pii

S0022282896901054

journal_volume

28

pub_type

杂志文章

相关文献

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY文献大全
  • On the nature of cell death during remodeling of hypertrophied human myocardium.

    abstract：:Cardiocyte loss during myocardial hypertrophy leads to progressive dysfunction in human hearts with chronic hemodynamic overload. The mechanism for such cell elimination is unknown. We examined lysosomal participation in cardiocytic degradation present in human cardiac biopsies, utilizing electron microscopic cytochem...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1999.1064

    authors： Yamamoto S,Sawada K,Shimomura H,Kawamura K,James TN

    更新日期：2000-01-01 00:00:00

  • Selective activation of the "b" splice variant of phospholipase Cbeta1 in chronically dilated human and mouse atria.

    abstract：:Atrial fibrillation (AF) is commonly associated with chronic dilatation of the left atrium, both in human disease and animal models. The immediate signaling enzyme phospholipase C (PLC) is activated by mechanical stretch to generate the Ca2+-releasing messenger inositol(1,4,5)trisphosphate (Ins(1,4,5)P3) and sn-1,2-di...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2009.08.020

    authors： Woodcock EA,Grubb DR,Filtz TM,Marasco S,Luo J,McLeod-Dryden TJ,Kaye DM,Sadoshima J,Du XJ,Wong C,McMullen JR,Dart AM

    更新日期：2009-11-01 00:00:00

  • Cardiac morphogenetic defects and conduction abnormalities in mice homozygously deficient for connexin40 and heterozygously deficient for connexin45.

    abstract：:Connexin40 (Cx40) and connexin45 (Cx45) are involved in both cardiac morphogenesis and propagation of electrical activity. We found that Cx40/Cx45 double deficiency (Cx40(-/-)/Cx45(+/-)) causes a variety of cardiac defects leading to high mortality during embryonic development and at birth. The majority of Cx40(-/-)/C...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2006.07.005

    authors： Krüger O,Maxeiner S,Kim JS,van Rijen HV,de Bakker JM,Eckardt D,Tiemann K,Lewalter T,Ghanem A,Lüderitz B,Willecke K

    更新日期：2006-11-01 00:00:00

  • Structural vs. contractile protein remodeling and myocardial stiffness in hypertrophied rat left ventricle.

    abstract：:Left ventricular pressure overload will result in the hypertrophic growth of the myocardium and in the rat may include a remodeling of both the structural and contractile proteins. As a result, an adaptive rise in active stiffness, or the force generating capacity of the myocardium, may occur. The relative importance ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(88)90597-4

    authors： Jalil JE,Doering CW,Janicki JS,Pick R,Clark WA,Abrahams C,Weber KT

    更新日期：1988-12-01 00:00:00

  • Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells reduces neointimal hyperplasia.

    abstract：:The activation of vascular smooth muscle cells (SMCs) in neointimal hyperplasia involves signaling through receptor tyrosine kinases as well as G protein-coupled receptors. Overexpression of G protein-coupled receptor kinase-2 (GRK2) in SMCs can attenuate mitogenic signaling and proliferation in response to not only s...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.2002.2092

    authors： Peppel K,Zhang L,Huynh TT,Huang X,Jacobson A,Brian L,Exum ST,Hagen PO,Freedman NJ

    更新日期：2002-10-01 00:00:00

  • Manipulation of intracellular sodium by extracellular divalent cations: a 23Na and 31P NMR study on intact rat hearts.

    abstract：:23Na and 31P NMR spectroscopy were used to follow intracellular [Na+] ([Na+]i) and energy metabolism in isolated, perfused rat hearts. During 30 min of Ca(2+)-free perfusion no significant change in [Na+]i could be detected, but during a subsequent 45 min period of ischemia [Na+]i rose significantly as expected, from ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1997.0578

    authors： Van Echteld CJ,Van Emous JG,Jansen MA,Schreur JH,Ruigrok TJ

    更新日期：1998-01-01 00:00:00

  • Shear stress-induced activation of Tie2-dependent signaling pathway enhances reendothelialization capacity of early endothelial progenitor cells.

    abstract：:Although endothelial progenitor cells (EPCs) play a pivotal role in the endothelial repair following arterial injury and shear stress has a beneficial effect on EPCs, however, the molecular mechanism underlying the influence of EPCs on the endothelial integrity and the regulation of shear stress on the EPC signaling r...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2012.01.019

    authors： Yang Z,Xia WH,Zhang YY,Xu SY,Liu X,Zhang XY,Yu BB,Qiu YX,Tao J

    更新日期：2012-05-01 00:00:00

  • The influence of lanthanum on the subcellular distribution of calcium in the perfused dog heart.

    abstract：:A newly developed method was used to make a direct study of the influence of lanthanum on the subcellular distribution of isotopic and elemental calcium in the isolated perfused dog heart. The trivalent cation was introduced into the heart for the last 5 min of a 60 min perfusion period. Developed pressure and dP/dt w...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(86)80944-0

    authors： Kolbeck RC,Speir WA Jr

    更新日期：1986-07-01 00:00:00

  • Metabolism, hypoxia and the diabetic heart.

    abstract：:The diabetic heart becomes metabolically remodelled as a consequence of exposure to abnormal circulating substrates and hormones. Fatty acid uptake and metabolism are increased in the type 2 diabetic heart, resulting in accumulation of intracellular lipid intermediates and an increased contribution of fatty acids towa...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2011.01.007

    authors： Heather LC,Clarke K

    更新日期：2011-04-01 00:00:00

  • Stretch-induced regulation of angiotensinogen gene expression in cardiac myocytes and fibroblasts: opposing roles of JNK1/2 and p38alpha MAP kinases.

    abstract：:The cardiac renin-angiotensin system (RAS) has been implicated in mediating myocyte hypertrophy, remodeling, and fibroblast proliferation in the hemodynamically overloaded heart. However, the intracellular signaling mechanisms responsible for regulation of angiotensinogen (Ao), a substrate of the RAS system, are large...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2008.09.121

    authors： Lal H,Verma SK,Golden HB,Foster DM,Smith M,Dostal DE

    更新日期：2008-12-01 00:00:00

  • Mitochondrial instability during regional ischemia-reperfusion underlies arrhythmias in monolayers of cardiomyocytes.

    abstract：:Regional depolarization of the mitochondrial network can alter cellular electrical excitability and increase the propensity for reentry, in part, through the opening of sarcolemmal KATP channels. Mitochondrial inner membrane potential (ΔΨm) instability or oscillation can be induced in myocytes by exposure to reactive ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2014.09.024

    authors： Solhjoo S,O'Rourke B

    更新日期：2015-01-01 00:00:00

  • De-novo collateral formation following acute myocardial infarction: Dependence on CCR2⁺ bone marrow cells.

    abstract：:Wide variation exists in the extent (number and diameter) of native pre-existing collaterals in tissues of different strains of mice, with supportive indirect evidence recently appearing for humans. This variation is a major determinant of the wide variation in severity of tissue injury in occlusive vascular disease. ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2015.07.020

    authors： Zhang H,Faber JE

    更新日期：2015-10-01 00:00:00

  • Influence of isoproterenol on contractile protein function, excitation-contraction coupling, and energy turnover of isolated nonfailing human myocardium.

    abstract：:Previous animal experiments indicated that the effects of catecholamines on myocardial function and subcellular systems vary considerably depending on the species and type of myocardium investigated. In the present study, we used isometric force and heat measurements to investigate the influence of isoproterenol on en...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1994.1165

    authors： Hasenfuss G,Mulieri LA,Leavitt BJ,Alpert NR

    更新日期：1994-11-01 00:00:00

  • Acute AT1R blockade prevents isoproterenol-induced injury in mdx hearts.

    abstract：BACKGROUND:Duchenne muscular dystrophy (DMD) is an X-linked disease characterized by skeletal muscle degeneration and a significant cardiomyopathy secondary to cardiomyocyte damage and myocardial loss. The molecular basis of DMD lies in the absence of the protein dystrophin, which plays critical roles in mechanical mem...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2019.01.013

    authors： Meyers TA,Heitzman JA,Krebsbach AM,Aufdembrink LM,Hughes R,Bartolomucci A,Townsend D

    更新日期：2019-03-01 00:00:00

  • Soluble epoxide hydrolase activation by S-nitrosation contributes to cardiac ischemia-reperfusion injury.

    abstract：:Cardiac ischemia-reperfusion (I/R) injury always accompanies recanalization treatment for myocardial infarction. Here we found soluble epoxide hydrolase (sEH), which metabolizes cardioprotective epoxyeicosatrienoic acids into less effective diols, was rapidly activated during myocardial reperfusion in both mouse and r...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2017.07.006

    authors： Ding Y,Li Y,Zhang X,He J,Lu D,Fang X,Wang Y,Wang J,Zhang Y,Qiao X,Gan LM,Chen C,Zhu Y

    更新日期：2017-09-01 00:00:00

  • The effects of trimetoquinol on the intact rabbit heart and myocardial adenylate cyclase activity: evidence for spare myocardial beta receptors.

    abstract：:We have compared and contrasted the actions of (-)isoproterenol and (+/-) trimetoquinol on rabbit heart preparations. In the presence of either GTP or Gpp[NH]p (guanosine-5'-(beta, gamma imino) triphosphate), trimetoquinol displayed partial agonist activity in stimulating adenylate cyclase activity in a particulate ra...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(85)80025-0

    authors： Babich M,Atkinson J,Piascik MT

    更新日期：1985-06-01 00:00:00

  • In vivo expression of a conditional TGF-beta1 transgene: no evidence for TGF-beta1 transgene expression in SM22alpha-tTA transgenic mice.

    abstract：:Transforming growth beta-1 (TGF-beta1) appears to play a critical role in the regulation of arterial intimal growth and the development of atherosclerosis. TGF-beta1 is expressed at increased levels in diseased arteries; however, its role in disease development remains controversial. Experiments in which TGF-beta1 is ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2005.09.015

    authors： Lee S,Agah R,Xiao M,Frutkin AD,Kremen M,Shi H,Dichek DA

    更新日期：2006-01-01 00:00:00

  • Non-coding RNAs as orchestrators of autophagic processes.

    abstract：:Autophagy is an important quality control mechanism present in all cells to maintain their cellular homeostasis. An imbalance in the autophagic process had been reported in numerous diseases including cardiovascular disease and is associated with serious consequences. Thus, knowledge of key regulators of cardiac autop...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2015.11.012

    authors： Gupta SK,Thum T

    更新日期：2016-06-01 00:00:00

  • Taurine antagonizes the increase in intracellular calcium concentration induced by alpha-adrenergic stimulation in freshly isolated guinea-pig cardiomyocytes.

    abstract：:The effect of taurine on phenylephrine alpha-adrenergic action was studied in freshly-isolated guinea-pig ventricular myocytes. Intracellular calcium concentration was measured at nearly physiological extracellular CaCl2 in both cell suspension using quin-2 (mean intracellular calcium concentration 154.0 +/- 8.0 nM, n...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(92)93092-x

    authors： Failli P,Fazzini A,Franconi F,Stendardi I,Giotti A

    更新日期：1992-11-01 00:00:00

  • Differential stress protein mRNA expression during early ischaemic preconditioning in the rabbit heart and its relationship to adenosine receptor function.

    abstract：:The aim of this study was: (1) to elucidate in more detail the relationship between stress protein expression and brief periods of ischaemia and reperfusion, such as occur during early (classical) ischaemic preconditioning (PC) in the rabbit myocardium; (2) to determine whether stress protein expression is affected by...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(95)91299-1

    authors： Heads RJ,Latchman DS,Yellon DM

    更新日期：1995-10-01 00:00:00

  • Localisation of cardiac GS alpha in transgenic mice overexpressing GS alpha.

    abstract：:The biochemical and physiological effects of GS alpha activation are well known; however, little is known about the anatomical localisation of GS alpha in the myocardium. Knowledge of the localisation might yield insights into G protein function in heart. The utility of immunocytochemistry using immunofluorescent meth...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1997.0400

    authors： Muntz KH,Ishikawa Y,Wagner T,Homcy CJ,Vatner SF,Vatner DE

    更新日期：1997-06-01 00:00:00

  • Norepinephrine pretreatment attenuates Ca2+ overloading in rat trabeculae during subsequent metabolic inhibition: improved contractile recovery via an alpha 1-adrenergic, PKC-dependent signaling mechanism.

    abstract：:The present study was designed in order to investigate more precisely the role of calcium homeostasis maintenance in protein kinase C (PKC) mediated preconditioning. We used a 15 min pre-incubation period, with 1 mumol/l exogenous norepinephrine (NE) to pharmacologically precondition isolated, superfused rat trabecula...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1996.0368

    authors： Musters RJ,van der Meulen ET,van der Laarse WJ,van Hardeveld C

    更新日期：1997-05-01 00:00:00

  • Contractile function of cardiomyocytes from the spontaneously hypertensive rat.

    abstract：:In essential hypertension it has been hypothesized that there is a generalized derangement in cellular Ca2+ homeostasis. The aim of this study was to assess whether there is functional evidence for increased vulnerability to Ca overload in cardiomyocytes derived from age-matched (11-week) normotensive Wistar-Kyoto (WK...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1996.0067

    authors： Delbridge LM,Connell PJ,Morgan TO,Harris PJ

    更新日期：1996-04-01 00:00:00

  • Evidence for electrogenic Na+ pumping in human atrial myocardium.

    abstract：:The resting potential of "sodium-loaded' cardiac cells can transiently hyperpolarize to levels negative to the steady state resting potential [3,5,6]. Hyperpolarization is associated with the coupled efflux of Na+ and influx of K+ driven by an active transport process and may result from an increased K+ equilibrium po...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(84)80660-4

    authors： Rasmussen HH,TenEick RE,McCullough JR,Singer DH

    更新日期：1984-08-01 00:00:00

  • Chemokine expression in myocardial ischemia: MIP-2 dependent MCP-1 expression protects cardiomyocytes from cell death.

    abstract：:Chemokines are small molecular weight proteins that play important roles in inflammation. Originally described as chemotactic cytokines, chemokines stimulate the influx of leukocytes into specific tissue compartments. These molecules also modulate gene expression in both infiltrating and resident cells to mediate a va...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.2001.1503

    authors： Tarzami ST,Cheng R,Miao W,Kitsis RN,Berman JW

    更新日期：2002-02-01 00:00:00

  • Isogenic models of hypertrophic cardiomyopathy unveil differential phenotypes and mechanism-driven therapeutics.

    abstract：BACKGROUND:Hypertrophic cardiomyopathy (HCM) is a prevalent and complex cardiovascular condition. Despite being strongly associated with genetic alterations, wide variation of disease penetrance, expressivity and hallmarks of progression complicate treatment. We aimed to characterize different human isogenic cellular m...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2020.06.003

    authors： Bhagwan JR,Mosqueira D,Chairez-Cantu K,Mannhardt I,Bodbin SE,Bakar M,Smith JGW,Denning C

    更新日期：2020-08-01 00:00:00

  • Targeting cardiac fibroblasts to treat fibrosis of the heart: focus on HDACs.

    abstract：:Cardiac fibrosis is implicated in numerous physiologic and pathologic conditions, including scar formation, heart failure and cardiac arrhythmias. However the specific cells and signaling pathways mediating this process are poorly understood. Lysine acetylation of nucleosomal histone tails is an important mechanism fo...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2014.02.015

    authors： Schuetze KB,McKinsey TA,Long CS

    更新日期：2014-05-01 00:00:00

  • β-Adrenergic induced SR Ca2+ leak is mediated by an Epac-NOS pathway.

    abstract：:Cardiac β-adrenergic receptors (β-AR) and Ca2+-Calmodulin dependent protein kinase (CaMKII) regulate both physiological and pathophysiological Ca2+ signaling. Elevated diastolic Ca2+ leak from the sarcoplasmic reticulum (SR) contributes to contractile dysfunction in heart failure and to arrhythmogenesis. β-AR activati...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2017.04.005

    authors： Pereira L,Bare DJ,Galice S,Shannon TR,Bers DM

    更新日期：2017-07-01 00:00:00

  • Effect of ATP depletion on kinetics of Na/Ca exchange-mediated Ca influx in Na-loaded heart cells.

    abstract：:The kinetics of Ca influx by Na/Ca exchange into adult rat heart cells loaded with Na and depleted of ATP were investigated, to further elucidate how ATP regulates exchanger properties in the intact heart cell. We found an eight-fold reduction in Vmax for Ca uptake by ATP depletion, with no significant change in the K...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1996.0294

    authors： Haworth RA,Biggs AV

    更新日期：1997-02-01 00:00:00

  • Regulation of L-type calcium channels of vascular smooth muscle cells.

    abstract：:Vascular tone is regulated by a variety of neurotransmitters, vasoactive hormones and autacoids, and vasoactive drugs. These actions are mediated, at least in part, by actions on the membrane ion channels, exerted either directly or indirectly. In this article, we described evidence that four different protein kinase ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/s0022-2828(08)80009-0

    authors： Xiong Z,Sperelakis N

    更新日期：1995-01-01 00:00:00