Abstract：
:HLA-DQA1 and polymarker (LDLR, GYPA, HBGG, D7S8, and GC) genotypic and allelic frequencies are determined for a population sample of 102 unrelated Basque individuals using PCR-based methodology. All six loci met Hardy-Weinberg expectations in at least two of the three analyses performed (HLA-DQA1 failed to meet Hardy-Weinberg requirements in the heterozygote deficiency test). Three linkage analysis programs (GDA, GENEPOP and LINKDOS) detected possible linkage disequilibrium between LDLR and HBGG and results from one (GDA) indicated a possible non-random association between HBGG and HLA-DQA1 as well. Allelic data for the six loci are compared to that previously established for other populations (18 for polymarker alone, 16 for polymarker plus HLA-DQA1) to determine homogeneity between the Basque sample and these groups. According to the results of G-tests based on these loci, the Tadjik, a nomadic Caucasian group from western Asia, and the Basque residents are the only sample populations surveyed that are homogenous with the Basque sample. Phylogenetic analysis places the Basque sample correctly within the Caucasian cluster.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Brown RJ,Rowold D,Tahir M,Barna C,Duncan G,Herrer RJdoi
10.1016/s0379-0738(99)00202-9keywords:
subject
Has Abstractpub_date
2000-02-14 00:00:00pages
145-51issue
2eissn
0379-0738issn
1872-6283pii
S0379073899002029journal_volume
108pub_type
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