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Direct determination of surface tension in the lung.

Abstract：

:We have used the spreading behavior of small drops of several fluorocarbon fluids and silicone oil on air-liquid interfaces to measure the surface tension of lungs in situ. The test fluids were calibrated in a surface balance at 37 degrees on monolayers of dipalmitoylphosphatidylcholine. At particular surface tensions characteristic of each fluid used, an increase in the tension of 1 mN/m or less caused the droplets to spread reversibly from a sphere to a lens shape. Using micropipettes we placed such droplets on the alveolar surfaces of excised rat lungs held at functional residual capacity and 37 degrees and found that the surface tension remained below 9 mN/m for at least 30 min. The surface tension-volume relationship was linear for tensions ranging from 9 to 20 mN/m.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Schürch S,Goerke J,Clements JA

doi

10.1073/pnas.73.12.4698

keywords:

subject

Has Abstract

pub_date

1976-12-01 00:00:00

pages

4698-702

issue

12

eissn

0027-8424

issn

1091-6490

journal_volume

73

pub_type

杂志文章

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