Expression and regulation of a molecular marker, SPR1, in multistep bronchial carcinogenesis.

abstract：:We have previously identified two integrins, alpha 9 beta 1 and alpha v beta 6, from guinea pig airway epithelium. The extracellular matrix protein tenascin is a ligand for both of these receptors, and fibronectin is also a ligand for alpha v beta 6. In the present study, we used immunohistochemistry to examine the ex...

journal_title：American journal of respiratory cell and molecular biology

authors： Weinacker A,Ferrando R,Elliott M,Hogg J,Balmes J,Sheppard D

更新日期：1995-05-01 00:00:00

abstract：:Cigarette smoke-induced apoptosis and necrosis contribute to the pathogenesis of chronic obstructive pulmonary disease. The induction of heme oxygenase-1 provides cytoprotection against oxidative stress, and may protect in smoking-related disease. Since mitochondria regulate cellular death, we examined the functional ...

journal_title：American journal of respiratory cell and molecular biology

authors： Slebos DJ,Ryter SW,van der Toorn M,Liu F,Guo F,Baty CJ,Karlsson JM,Watkins SC,Kim HP,Wang X,Lee JS,Postma DS,Kauffman HF,Choi AM

更新日期：2007-04-01 00:00:00

abstract：:Human rhinovirus (HRV) infections are associated with exacerbations of lower-airway diseases. HRV-induced production of proinflammatory chemokines, such as CXCL10, from infected airway epithelial cells may play a role in the pathogenesis of exacerbations. We have previously shown that the MAP/ERK kinase (MEK) pathway ...

journal_title：American journal of respiratory cell and molecular biology

authors： Zaheer RS,Proud D

更新日期：2010-10-01 00:00:00

abstract：:The dynamics and mechanisms of extracellular release of hydrogen peroxide (H2O2) from bovine pulmonary artery endothelial cells (EC) subjected to anoxia, hypoxia, and hypoxia followed by reoxygenation were examined using various inhibitors of enzymatic systems in intact cells and by direct measurement of H2O2 producti...

journal_title：American journal of respiratory cell and molecular biology

authors： Zulueta JJ,Yu FS,Hertig IA,Thannickal VJ,Hassoun PM

更新日期：1995-01-01 00:00:00

abstract：:To better understand asthma pathogenesis, we characterized airway responsiveness, lung inflammation, and mediator production of alveolar macrophages (AM) after allergen sensitization and challenge in two strains of rats showing different susceptibilities in developing airway allergic reactions. Airway responsiveness t...

journal_title：American journal of respiratory cell and molecular biology

authors： Careau E,Sirois J,Bissonnette EY

更新日期：2002-05-01 00:00:00

abstract：:Hexavalent chromium (Cr[VI]) is classified by the International Agency for Research on Cancer as a group I carcinogen. Although the U.S. Occupational Safety and Health Administration was obliged to reduce the permissible exposure limit (PEL), it was reported that U.S. workers continue to be exposed to dangerously high...

journal_title：American journal of respiratory cell and molecular biology

authors： Russo P,Catassi A,Cesario A,Imperatori A,Rotolo N,Fini M,Granone P,Dominioni L

更新日期：2005-12-01 00:00:00

abstract：:Tissue inhibitors of metalloproteinases (TIMPs) are multifunctional proteins that have the capacity to modify cellular activities and to modulate matrix turnover. We demonstrate that TIMP-1 messenger RNA (mRNA) and protein expression are selectively and markedly increased in a murine model of bleomycin-induced pulmona...

journal_title：American journal of respiratory cell and molecular biology

authors： Madtes DK,Elston AL,Kaback LA,Clark JG

更新日期：2001-05-01 00:00:00

abstract：:Two isoforms of the human glucocorticoid receptor (hGR) have been described, hGRalpha and hGRbeta. We analyzed the expression and regulation of both hGR isoforms in human respiratory epithelial cells (BEAS-2B, A549, and primary nasal epithelial cells). In BEAS-2B cells, the expression of hGRalpha messenger RNA (mRNA) ...

journal_title：American journal of respiratory cell and molecular biology

authors： Pujols L,Mullol J,Pérez M,Roca-Ferrer J,Juan M,Xaubet A,Cidlowski JA,Picado C

更新日期：2001-01-01 00:00:00

abstract：:Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are major causes of acute respiratory failure with high rates of morbidity and mortality. Although surfactant protein (SP)-D plays a critical role in pulmonary innate immunity and several clinical studies suggest that this protein...

journal_title：American journal of respiratory cell and molecular biology

authors： King BA,Kingma PS

更新日期：2011-05-01 00:00:00

abstract：:Macrophages are key orchestrators of the inflammatory and repair responses in the lung, and the diversity of their function is indicated by their polarized states and distinct subpopulations and localization in the lung. Here, we characterized the pulmonary macrophage populations in the interstitial and alveolar compa...

journal_title：American journal of respiratory cell and molecular biology

authors： Johnston LK,Rims CR,Gill SE,McGuire JK,Manicone AM

更新日期：2012-10-01 00:00:00

abstract：:Lung transplantation remains the only therapeutic option for many patients suffering from end-stage pulmonary disease. Long-term success after lung transplantation is severely limited by the development of bronchiolitis obliterans. The murine heterotopic tracheal transplantation model has been widely used for studies ...

journal_title：American journal of respiratory cell and molecular biology

authors： Okazaki M,Gelman AE,Tietjens JR,Ibricevic A,Kornfeld CG,Huang HJ,Richardson SB,Lai J,Garbow JR,Patterson GA,Krupnick AS,Brody SL,Kreisel D

更新日期：2007-12-01 00:00:00

abstract：:Cystic fibrosis (CF) is characterized by a dramatic neutrophil recruitment and repeated Pseudomonas infections in the lungs. To evaluate cytokine releasibility by airway epithelial cells in the context of CF, we studied primary nasal epithelial cells isolated from the upper airways and continuous epithelial cell lines...

journal_title：American journal of respiratory cell and molecular biology

authors： Bédard M,McClure CD,Schiller NL,Francoeur C,Cantin A,Denis M

更新日期：1993-10-01 00:00:00

abstract：:Interleukin (IL)-4 and (IL)-13 induce immunoglobulin (Ig)E synthesis via activation of the transcription factor signal transducer and activator of transcription (Stat)6. The present study describes the identification and characterization of antisense oligonucleotides to Stat6 as an approach to interrupt IL-4 and IL-13...

journal_title：American journal of respiratory cell and molecular biology

authors： Hill S,Herlaar E,Le Cardinal A,van Heeke G,Nicklin P

更新日期：1999-12-01 00:00:00

abstract：:Airway neutrophilia is a prominent feature of chronic obstructive pulmonary disease. As cigarette smoke (CS) and epidermal growth factor (EGF) both cause release of interleukin-8 (IL-8) from epithelial cells in vitro, we investigated whether autocrine ligands for the EGF receptor (EGFR) are involved in this proinflamm...

journal_title：American journal of respiratory cell and molecular biology

authors： Richter A,O'Donnell RA,Powell RM,Sanders MW,Holgate ST,Djukanović R,Davies DE

更新日期：2002-07-01 00:00:00

abstract：:Pulmonary carbonic anhydrase (CA) activity plays important roles in carbon dioxide exchange, fluid secretion, and pH regulation. This study reports the use of molecular and immunologic techniques to characterize expression of the high-activity cytosolic isoenzyme CA II in rat lung tissue. Northern blot analysis of RNA...

journal_title：American journal of respiratory cell and molecular biology

authors： Fleming RE,Moxley MA,Waheed A,Crouch EC,Sly WS,Longmore WJ

更新日期：1994-05-01 00:00:00

abstract：:Studies in animals and in human atopic skin suggest that allergen challenge may activate acute tissue remodeling changes via transforming growth factor-beta pathways. We determined whether inhalational allergen challenge in subjects with mild asthma induces similar acute changes to the airway epithelial mesenchymal tr...

journal_title：American journal of respiratory cell and molecular biology

authors： Phipps S,Benyahia F,Ou TT,Barkans J,Robinson DS,Kay AB

更新日期：2004-12-01 00:00:00

abstract：:The objective of this study was to define phenotypic changes of antigen-presenting cells (APCs) and T cells in a murine model of antigen-induced airways inflammation that involves intraperitoneal sensitization with ovalbumin (OVA)/adjuvant followed by antigen aerosolization. We investigated the APC and T-cell compartm...

journal_title：American journal of respiratory cell and molecular biology

authors： Gajewska BU,Swirski FK,Alvarez D,Ritz SA,Goncharova S,Cundall M,Snider DP,Coyle AJ,Gutierrez-Ramos JC,Stämpfli MR,Jordana M

更新日期：2001-09-01 00:00:00

abstract：:Cigarette smoking and aging are major risk factors for chronic obstructive pulmonary disease. An unsolved question is whether elderly lungs are particularly vulnerable to cigarette smoke (CS) exposure. In this study, we used a mouse model to test the hypothesis that aging increases the susceptibility to CS-induced pul...

journal_title：American journal of respiratory cell and molecular biology

authors： Moriyama C,Betsuyaku T,Ito Y,Hamamura I,Hata J,Takahashi H,Nasuhara Y,Nishimura M

更新日期：2010-03-01 00:00:00

abstract：:IL-11 and IL-11 receptor (R)alpha are induced by Th2 cytokines. However, the role(s) of endogenous IL-11 in antigen-induced Th2 inflammation has not been fully defined. We hypothesized that IL-11, signaling via IL-11Ralpha, plays an important role in aeroallergen-induced Th2 inflammation and mucus metaplasia. To test ...

journal_title：American journal of respiratory cell and molecular biology

authors： Lee CG,Hartl D,Matsuura H,Dunlop FM,Scotney PD,Fabri LJ,Nash AD,Chen NY,Tang CY,Chen Q,Homer RJ,Baca M,Elias JA

更新日期：2008-12-01 00:00:00

abstract：:Specific changes in composition and content of lung extracellular matrix (ECM) proteoglycans (PGs) and hyaluronan (HA) have been observed during the acute response to damage in several forms of injury including infant respiratory distress syndrome (IRDS). These ECM components are thought to modulate the healing respon...

journal_title：American journal of respiratory cell and molecular biology

authors： Juul SE,Krueger RC Jr,Scofield L,Hershenson MB,Schwartz NB

更新日期：1995-12-01 00:00:00

abstract：:Laminins are heterotrimeric proteins that are secreted by the alveolar epithelium into the basement membrane, and their expression is altered in extracellular matrices from patients with pulmonary fibrosis. In a small number of patients with pulmonary fibrosis, we found that the normal basement membrane distribution o...

journal_title：American journal of respiratory cell and molecular biology

authors： Morales-Nebreda LI,Rogel MR,Eisenberg JL,Hamill KJ,Soberanes S,Nigdelioglu R,Chi M,Cho T,Radigan KA,Ridge KM,Misharin AV,Woychek A,Hopkinson S,Perlman H,Mutlu GM,Pardo A,Selman M,Jones JC,Budinger GR

更新日期：2015-04-01 00:00:00

abstract：:The nose is an attractive source of airway epithelial cells, particularly in populations in which bronchoscopy may not be possible. However, substituting nasal cells for bronchial epithelial cells in the study of airway inflammation depends upon comparability of responses, and evidence for this is lacking. Our objecti...

journal_title：American journal of respiratory cell and molecular biology

authors： McDougall CM,Blaylock MG,Douglas JG,Brooker RJ,Helms PJ,Walsh GM

更新日期：2008-11-01 00:00:00

abstract：:Fibroblasts are the central target cell in pulmonary fibrotic diseases, and their proliferation is mediated largely by platelet-derived growth factor (PDGF) isoforms secreted by activated lung macrophages. Several other macrophage-derived cytokines that are increased during fibrogenesis, including interleukin-1 beta a...

journal_title：American journal of respiratory cell and molecular biology

authors： Bonner JC,Badgett A,Lindroos PM,Osornio-Vargas AR

更新日期：1995-10-01 00:00:00

abstract：:We have reported that von Hippel-Lindau protein (pVHL) expression is elevated in human and mouse fibrotic lungs and that overexpression of pVHL stimulates fibroblast proliferation. We sought to determine whether loss of pVHL in fibroblasts prevents injury and fibrosis in mice that are treated with bleomycin. We genera...

journal_title：American journal of respiratory cell and molecular biology

authors： Zhou Q,Chen T,Zhang W,Bozkanat M,Li Y,Xiao L,van Breemen RB,Christman JW,Sznajder JI,Zhou G

更新日期：2016-05-01 00:00:00

abstract：:Receptors for advanced glycation end-products (RAGEs) are multiligand cell surface receptors highly expressed in the lung that contribute to alveolar epithelial cell differentiation during embryogenesis and the modulation of pulmonary inflammation during disease. When RAGEs are overexpressed throughout embryogenesis, ...

journal_title：American journal of respiratory cell and molecular biology

authors： Stogsdill JA,Stogsdill MP,Porter JL,Hancock JM,Robinson AB,Reynolds PR

更新日期：2012-07-01 00:00:00

abstract：:A murine model was used to assess the role of cytokines in initiating protective T-cell-mediated immunity in the lung. A pulmonary infection was initiated by intratracheal inoculation of Cryptococcus neoformans (Cne). Previously, we had established that Cne lung clearance was mouse-strain-specific: C.B-17 mice were re...

journal_title：American journal of respiratory cell and molecular biology

authors： Hoag KA,Lipscomb MF,Izzo AA,Street NE

更新日期：1997-12-01 00:00:00

abstract：:Type 2 alveolar epithelial cells (AEC2) are regarded as the progenitor population of the alveolus responsible for injury repair and homeostatic maintenance. Depletion of this population is hypothesized to underlie various lung pathologies. Current models of lung injury rely on either uncontrolled, nonspecific destruct...

journal_title：American journal of respiratory cell and molecular biology

authors： Garcia O,Hiatt MJ,Lundin A,Lee J,Reddy R,Navarro S,Kikuchi A,Driscoll B

更新日期：2016-03-01 00:00:00

abstract：:Platelet-activating factor (PAF), a proinflammatory lipid mediator, is a potent airway mucin secretagogue. This study assessed the role of protein kinase C (PKC) in PAF-induced mucin release from primary cultures of feline tracheal epithelial cells (FTEC). Mucin secretion was quantitated by enzyme-linked immunosorbent...

journal_title：American journal of respiratory cell and molecular biology

authors： Larivée P,Levine SJ,Martinez A,Wu T,Logun C,Shelhamer JH

更新日期：1994-08-01 00:00:00

abstract：:The capacity of Mycobacterium tuberculosis (MTB) to induce production of chemokines with known chemotactic activity for monocytes and lymphocytes, the cellular building blocks of granulomas, was investigated. These chemokines included regulated upon activation, normal T cell expressed and secreted (RANTES), monocyte c...

journal_title：American journal of respiratory cell and molecular biology

authors： Sadek MI,Sada E,Toossi Z,Schwander SK,Rich EA

更新日期：1998-09-01 00:00:00

abstract：:Endotoxin lipopolysaccharide and the cytokines, tumor necrosis factor (TNF) and interleukin-1 (IL-1), are known to protect adult rats against O2 toxicity. However, whether the effect of endotoxin is mediated by these cytokines is not clear. We have previously demonstrated that depletion of 84% rat alveolar macrophages...

journal_title：American journal of respiratory cell and molecular biology

authors： Tang G,White JE,Lumb PD,Lawrence DA,Tsan MF

更新日期：1995-03-01 00:00:00