Neuromyotonia, myocloni, sensory neuropathy and cerebellar symptoms in a patient with antibodies to neuronal nucleoproteins (anti-Hu-antibodies).

Abstract:

:A middle-aged patient presented with subacute muscular stiffness, myocloni of both extremity and facial muscles, gait ataxia and symmetrical distal painful paraesthesias. Electrophysiologically, neuromyotonia was confirmed. High titer anti-Hu antibodies were detected, but no other paraneoplastic antibodies were found. Small-cell lung cancer was diagnosed. Under chemotherapy tumor remission was achieved and, except for minor sensory deficits, neurological symptoms disappeared. This report shows that paraneoplastic syndromes associated with antibodies to neuronal nucleoproteins (anti-Hu antibodies) may be associated with a syndrome including neuromyotonia, sensory neuropathy, cerebellar symptoms and myocloni.

journal_name

Clin Neurol Neurosurg

authors

Toepfer M,Schroeder M,Unger JW,Lochmüller H,Pongratz D,Müller-Felber W

doi

10.1016/s0303-8467(99)00037-2

keywords:

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

207-9

issue

3

eissn

0303-8467

issn

1872-6968

pii

S0303846799000372

journal_volume

101

pub_type

杂志文章
  • Miller Fisher syndrome associated with Mycoplasma pneumoniae infection: report of a case.

    abstract::We report a 38-year-old male patient who developed a Miller Fisher syndrome following a respiratory tract disorder associated with a serologically proven Mycoplasma pneumoniae infection. Although several neurologic manifestations have been reported after Mycoplasma pneumonia infection, Miller Fisher syndrome has not b...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/0303-8467(94)90038-8

    authors: Merkx H,De Keyser J,Ebinger G

    更新日期:1994-02-01 00:00:00

  • Treatment of sleep disorders may improve fatigue in multiple sclerosis.

    abstract:OBJECTIVE:In a previous polysomnographic cross-sectional study we found a significant relationship between sleep disorders and multiple sclerosis (MS) related fatigue. The purpose of this open follow-up observation was to compare the impact of treatment of sleep disorders on MS related fatigue measured with the Modifie...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.clineuro.2013.05.018

    authors: Veauthier C,Gaede G,Radbruch H,Gottschalk S,Wernecke KD,Paul F

    更新日期:2013-09-01 00:00:00

  • Progressive multifocal leukoencephalopathy developed in incomplete Heerfordt syndrome, a rare manifestation of sarcoidosis, without steroid therapy responding to cidofovir.

    abstract::Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system caused by the JC virus; the mortality rate is high and it is usually refractory to treatment. In non-HIV patients, PML occurs as a late consequence of hematologic malignancies or during prolonged immunosupp...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.clineuro.2009.10.005

    authors: Yagi T,Hattori H,Ohira M,Nakamichi K,Takayama-Ito M,Saijo M,Shimizu T,Ito D,Takahashi K,Suzuki N

    更新日期:2010-02-01 00:00:00

  • Reduction of shunt obstructions by using a peel-away sheath technique? A multicenter prospective randomized trial.

    abstract:OBJECTIVE:Shunt obstructions may partly be caused by brain debris, which intrude into the ventricular catheter during ventricle puncture. Avoiding contact between the catheter and brain tissue, by using a peel-away sheath, should reduce the number of shunt failures caused by obstruction. To test this hypothesis, we con...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.clineuro.2011.11.020

    authors: Kehler U,Langer N,Gliemroth J,Meier U,Lemcke J,Sprung C,Schlosser HG,Kiefer M,Eymann R,Heese O

    更新日期:2012-05-01 00:00:00

  • Results and risk factors for recurrence following endoscopic endonasal transsphenoidal surgery for pituitary adenoma.

    abstract:BACKGROUND:Endoscopic endonasal (EE) transsphenoidal surgery is an important surgical approach to the treatment of sellar pathology, particularly for pituitary adenomas. Risk factors for the radiographic recurrence of pituitary adenomas resected using a purely endoscopic approach have not been established. This study i...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.clineuro.2014.01.020

    authors: Bodhinayake I,Ottenhausen M,Mooney MA,Kesavabhotla K,Christos P,Schwarz JT,Boockvar JA

    更新日期:2014-04-01 00:00:00

  • The impact of the international subarachnoid aneurysm trial (ISAT) on the management of aneurysmal subarachnoid haemorrhage in a neurosurgical unit in the UK.

    abstract:OBJECTIVE:To review the changes in the management of aneurysmal subarachnoid haemorrhage (SAH) in a single neurosurgical unit in the UK, following the publication of the international subarachnoid aneurysm trial (ISAT). METHODS:The presentation, investigations, treatments and outcome data of all patients admitted with...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.clineuro.2005.11.001

    authors: Gnanalingham KK,Apostolopoulos V,Barazi S,O'Neill K

    更新日期:2006-02-01 00:00:00

  • Surgical management of arrested hydrocephalus: Case report, literature review, and 18-month follow-up.

    abstract:OBJECTIVE:Arrested hydrocephalus is stable ventriculomegaly without evidence of neurologic deterioration or symptoms. Management of arrested hydrocephalus in asymptomatic adults is controversial, with little clinical data. This case highlights the potential for decompensation in adults with arrested hydrocephalus and r...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.clineuro.2016.10.017

    authors: Hong J,Barrena BG,Lollis SS,Bauer DF

    更新日期:2016-12-01 00:00:00

  • Successful treatment of amoebic meningoencephalitis in a Chinese living in Hong Kong.

    abstract::Primary amoebic meningoencephalitis due to Naegleria fowleri was found in a 38-year-old Chinese man living in Hong Kong who presumably acquired the infection from swimming in a hot spring in neighbouring China. Amoebic cysts were identified in tissue taken from a brain abscess. The patient responded to surgical draina...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/0303-8467(93)90132-z

    authors: Wang A,Kay R,Poon WS,Ng HK

    更新日期:1993-09-01 00:00:00

  • Differentiating pseudo-occlusion from true occlusion of proximal internal carotid artery in acute ischemic stroke on CT angiography.

    abstract:OBJECTIVE:A lack of visualization of the proximal internal carotid artery (ICA) on computed tomography angiography (CTA) in acute ischemic stroke may be caused by an atherosclerotic occlusion or a pseudo-occlusion by a massive thrombus in the ICA. Pseudo-occlusion of the proximal ICA is caused by stagnant flow from a d...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.clineuro.2019.105495

    authors: Kim H,Kwak HS,Chung GH,Hwang SB

    更新日期:2019-10-01 00:00:00

  • Hypothalamic Hamartomas: A Comprehensive Review of Literature - Part 3: Updates on Radiotherapy Management.

    abstract::Hypothalamic hamartomas (HH) are rare, non-neoplastic heterotopic tissues which contains normal neurons and glia including oligodendrocytes and fibrillary astrocytes but in an abnormal distribution. They arise from the floor of the third ventricle, tuber cinereum, or mammillary bodies. Estimated incidence ranges from ...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.clineuro.2020.106077

    authors: Alomari SO,El Houshiemy MN,Bsat S,Moussalem CK,Allouh M,Omeis IA

    更新日期:2020-10-01 00:00:00

  • Bilateral ethmoidal dural arteriovenous fistula: unexpected surgical diagnosis.

    abstract::Dural arteriovenous fistulae (DAVFs) are infrequent lesions, the most common locations of which are the cavernous, sigmoid and transverse sinuses. The cribiform plate is one of the less frequent sites for DAVFs, where they entail a high hemorrhage risk. Feeding arteries for ethmoidal DAVFs can be uni- or bilateral. Ho...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.clineuro.2010.07.006

    authors: Ros de San Pedro J,Pérez CJ,Parra JZ,López-Guerrero AL,Sánchez JF

    更新日期:2010-12-01 00:00:00

  • Does postoperative PI-LL mismatching affect surgical outcomes in thoracolumbar kyphosis associated with ankylosing spondylitis patients?

    abstract:OBJECTIVE:To investigate if pelvic incidence (PI) and lumbar lordosis (LL) mismatching affects surgical outcomes for ankylosing spondylitis (AS) related kyphosis following 1-level lumbar pedicle subtraction osteotomy (PSO). PATIENTS AND METHODS:AS patients with thoracolumbar kyphosis, who underwent 1-level lumbar PSO ...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.clineuro.2018.04.006

    authors: Liu ZJ,Qian BP,Qiu Y,Mao SH,Jiang J,Wang B

    更新日期:2018-06-01 00:00:00

  • Assessment of the effect of short-term factors on surgical treatments for hypertensive intracerebral haemorrhage.

    abstract:BACKGROUND:Hypertension is the most common cause of intracerebral haemorrhages (ICHs), yet the short-term impact factors associated with hypertensive intracerebral haemorrhages (HICHs) in patients who undergo different surgical treatments are still unknown. MATERIALS AND METHODS:All consecutive patients with acute HIC...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.clineuro.2016.08.023

    authors: Zhao Z,Wang H,Li Z,Wang X,Zhang W,Feng K,Fan J

    更新日期:2016-11-01 00:00:00

  • Traumatic atypical Brown-Sequard syndrome: case report and literature review.

    abstract::A man was kicked on the neck, 10 days after which he noted right-sided numbness. Clinically, he had diminished deep tendon reflexes over the left upper limb, absent left superficial abdominal reflexes, a left extensor plantar response, mild left hemiparesis, diminished pinprick, temperature and vibratory sensation up ...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/s0303-8467(03)00009-x

    authors: Lim E,Wong YS,Lo YL,Lim SH

    更新日期:2003-04-01 00:00:00

  • Does kyphotic configuration on upright lateral radiograph correlate with instability in patients with degenerative lumbar spondylolisthesis?

    abstract:OBJECTIVE:To investigate the segmental instability of degenerative lumbar spondylolisthesis (DLS) with a kyphotic configuration at the involved segment, and to determine the most useful diagnostic modalities in the evaluation of instability. PATIENTS AND METHODS:This study reviewed a consecutive series of patients wit...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.clineuro.2018.07.020

    authors: Chen X,Zhou QS,Xu L,Chen ZH,Zhu ZZ,Li S,Qiu Y,Sun X

    更新日期:2018-10-01 00:00:00

  • Intraoperative bilateral cavernous sinus sampling for ACTH measurements during transsphenoidal pituitary surgery in patients with Cushing's disease.

    abstract::Intraoperative bilateral cavernous sinus sampling combined with rapid ACTH measurement was performed in a pilot study in seven patients with Cushing's disease during transsphenoidal pituitary surgery before and immediately after removal of the ACTH-producing pituitary microadenoma. Before tumor removal a gradient in A...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/s0303-8467(02)00028-8

    authors: Czirják S,Bezzegh A,Gál A,Rácz K

    更新日期:2002-09-01 00:00:00

  • The potential use of adult stem cells for the treatment of multiple sclerosis and other neurodegenerative disorders.

    abstract::No specific treatment exists for patients with multiple sclerosis (MS) who fail to respond to conventional immunosuppressive and immunomodulating modalities. Furthermore, no method is available for regeneration of existing defect in the central nervous system (CNS). The ultimate goals of MS treatment, similarly to oth...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.clineuro.2008.01.014

    authors: Slavin S,Kurkalli BG,Karussis D

    更新日期:2008-11-01 00:00:00

  • Recurrent forms of sporadic brachial plexus neuropathy. A report of two cases.

    abstract::Two patients presenting a relapsing form of sporadic brachial plexus neuropathy, the so-called Parsonage Turner syndrome, are reported. The diagnosis is based on clinical and electromyographic features. Recurrent attacks, although infrequently encountered, have been well described in the past. Sporadic cases of this s...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/s0303-8467(88)80014-3

    authors: Michotte A,Dierckx R,Deleu D,Herregodts P,Schmedding E,Bruyland M,Ebinger G

    更新日期:1988-01-01 00:00:00

  • Ulcerative colitis and interstitial myositis.

    abstract::Amongst the protean extra-intestinal manifestations of inflammatory bowel disease, scant mention is made of muscle involvement. This report outlines the clinical features, electrodiagnostic and muscle biopsy findings in a patient with ulcerative colitis who developed progressive proximal muscle weakness. The demonstra...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/s0303-8467(87)80026-4

    authors: Bhigjee AI,Bill PL,Cosnett JE

    更新日期:1987-01-01 00:00:00

  • Anatomico-radiologic study of the distribution of the suboccipital artery of Salmon.

    abstract:OBJECTIVES:The frequency of suboccipital injections to treat headaches has increased. The third segment of the vertebral artery is located in the suboccipital triangle and its main muscular branch, the suboccipital artery of Salmon (SAS), supplies blood to the suboccipital muscles. The purpose of this study was to radi...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.clineuro.2013.11.020

    authors: Macchi V,Porzionato A,Morra A,D'Antoni AV,Tubbs RS,De Caro R

    更新日期:2014-02-01 00:00:00

  • Subacute pancerebellar syndrome associated with systemic lupus erythematosus.

    abstract::A pancerebellar syndrome of subacute progression associated with cerebellar atrophy is highly suggestive of a paraneoplastic cerebellar degeneration (PCD). We describe a 27-year-old woman with systemic lupus erythematosus (SLE) that presented with a subacute pancerebellar syndrome. Serum and CSF anti-Yo, anti-Hu and a...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/0303-8467(96)00013-3

    authors: Manto MU,Rondeaux P,Jacquy J,Hildebrand JG

    更新日期:1996-05-01 00:00:00

  • Hypofractionated stereotactic radiotherapy combined with chemotherapy or not in the management of recurrent malignant gliomas: A systematic review and meta-analysis.

    abstract::Hypofractionated stereotactic radiotherapy (HFSRT) is a common salvage treatment for recurrent malignant glioma (MG). However, it remains controversial whether the combination of HFSRT and chemotherapy could improve survival for patients with recurrent MG compared to HFSRT alone. The present systematic review and meta...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.clineuro.2019.105401

    authors: Hu YJ,Zhang LF,Ding C,Chen D,Chen J

    更新日期:2019-08-01 00:00:00

  • The change of cervical sagittal alignment after surgery for adolescent idiopathic scoliosis.

    abstract:OBJECTIVE:The postoperative change in cervical sagittal alignment has an impact on health-related quality of life in adolescent idiopathic scoliosis (AIS) patients who have undergone deformity correction. However, the effect of deformity correction on sagittal cervical profile is still controversial in the literatures....

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.clineuro.2018.04.019

    authors: Luo SG,Zhong ZM,Zhu SY,Chen JT

    更新日期:2018-08-01 00:00:00

  • A detailed analysis of intracerebral hemorrhages in DBS surgeries.

    abstract:OBJECTIVES:Deep brain stimulation is nowadays a frequently performed surgery in patients with movement disorders, intractable epilepsy, and severe psychiatric disorders. The most feared complication of this surgery is an intracerebral hemorrhage due to the electrode placement, either for intraoperative electrophysiolog...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.clineuro.2015.10.017

    authors: Tonge M,Ackermans L,Kocabicak E,van Kranen-Mastenbroek V,Kuijf M,Oosterloo M,Kubben P,Temel Y

    更新日期:2015-12-01 00:00:00

  • New onset of idiopathic bilateral ear tics in an adult.

    abstract::Tic disorders are commonly considered to be childhood syndromes. Newly presenting tic disorders during adulthood are uncommon and mostly described in relation to an acquired brain lesion or as incidental tics, particularly in context with other neurological or psychiatric diseases. Tic disorder involving the ears is e...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.clineuro.2008.11.014

    authors: Agrawal A,Shrestha R

    更新日期:2009-04-01 00:00:00

  • Optic nerve MRI enhancement in posterior ischaemic optic neuropathy due to internal carotid artery dissection.

    abstract::Posterior ischaemic neuropathy (PION) is characterized by infarction in the retrobulbar optic nerve. A 73-year-old man suddenly experienced blurred vision in his left eye and intermittent weakness in his right hand. He had visual defects of superior lateral quarter and inferior medial quarter areas in the left eye. Ga...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.clineuro.2009.12.008

    authors: Kawabe K,Nagaoka T,Iguchi H,Ikeda K,Iwasaki Y

    更新日期:2010-05-01 00:00:00

  • Next generation sequencing for neurological diseases: new hope or new hype?

    abstract::Over the past year huge advances have been made in our ability to determine the genetic aetiology of many neurological diseases through the utilisation of next generation sequencing platforms. This technology is, on a daily basis, providing new breakthroughs in neurological disease. The aim of this article is to clear...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.clineuro.2012.09.030

    authors: Keogh MJ,Chinnery PF

    更新日期:2013-07-01 00:00:00

  • Tacrolimus-related polyneuropathy: case report and review of the literature.

    abstract::Patients, in particular recipients of orthotopic liver transplants, receiving the immunosuppressant tacrolimus (FK-506), are at risk for developing central neurotoxic adverse events. We report the occurrence of a tacrolimus-induced peripheral neurotoxic event, i.e. pure motor axonal polyneuropathy of the lower limbs i...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.clineuro.2007.10.014

    authors: De Weerdt A,Claeys KG,De Jonghe P,Ysebaert D,Chapelle T,Roeyen G,Jorens PG

    更新日期:2008-03-01 00:00:00

  • Syndrome of continuous muscle fibre activity confined to the legs.

    abstract::We report a 35-year-old woman with painful muscle cramps in both legs, this being the only symptom of the syndrome of continuous muscle fibre activity. Diagnosis was confirmed by electromyography during sleep. ...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/0303-8467(90)90035-4

    authors: de Waal M,Bertelsmann FW,Strijers RL

    更新日期:1990-01-01 00:00:00

  • Pregnancy and multiple sclerosis: the influence on long term disability.

    abstract::We studied 200 female patients with multiple sclerosis (MS) to investigate whether pregnancy after the onset of disease influences long term disability. As an index of progression, we used the time between disease onset and wheelchair dependence. Patients who had at least one pregnancy after onset were wheelchair depe...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章

    doi:10.1016/0303-8467(94)90027-2

    authors: Verdru P,Theys P,D'Hooghe MB,Carton H

    更新日期:1994-02-01 00:00:00