Abstract:
:Hb-Alberta has been found in a 51 year old Caucasian male with erythrocytosis. The substitution in this variant involves the glutamyl residue in position 101(G3) of the beta chain which is replaced by a glycyl residue. Hb-Alberta accounts for about 45% in the heterozygote, and readily forms hybrid tetramers with other hemoglobins. The oxygen affinity of Hb-Alberta is greatly increased, its Bohr effect reduced, and its subunit interaction greatly diminished.
journal_name
Hemoglobinjournal_title
Hemoglobinauthors
Mant MJ,Salkie ML,Cope N,Appling F,Bolch K,Jayalakshmi M,Gravely M,Wilson JB,Huisman THdoi
10.3109/03630267608991679keywords:
subject
Has Abstractpub_date
1976-01-01 00:00:00pages
183-94issue
2eissn
0363-0269issn
1532-432Xjournal_volume
1pub_type
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