Abstract：
:Backcross populations are often used to study quantitative trait loci (QTL) after they are initially discovered in balanced populations, such as F(2), BC(1), or recombinant inbreds. While the latter are more powerful for mapping marker loci, the former have the reduced background genetic variation necessary for more precise estimation of QTL effects. Many populations of inbred backcross lines (IBLs) have been developed in plant and animal systems to permit simultaneous study and dissection of quantitative genetic variation introgressed from one source to another. Such populations have a genetic structure that can be used for linkage estimation and discovery of QTL. In this study, four populations of IBLs of oilseed Brassica napus were developed and analyzed to map genomic regions from the donor parent (a winter-type cultivar) that affect agronomic traits in spring-type inbreds and hybrids. Restriction fragment length polymorphisms (RFLPs) identified among the IBLs were used to calculate two-point recombination fractions and LOD scores through grid searches. This information allowed the enrichment of a composite genetic map of B. napus with 72 new RFLP loci. The selfed and hybrid progenies of the IBLs were evaluated during two growing seasons for several agronomic traits. Both pedigree structure and map information were incorporated into the QTL analysis by using a regression approach. The number of QTL detected for each trait and the number of effective factors calculated by using biometrical methods were of similar magnitude. Populations of IBLs were shown to be valuable for both marker mapping and QTL analysis.
journal_name
Geneticsjournal_title
Geneticsauthors
Butruille DV,Guries RP,Osborn TCkeywords:
subject
Has Abstractpub_date
1999-10-01 00:00:00pages
949-64issue
2eissn
0016-6731issn
1943-2631journal_volume
153pub_type
杂志文章相关文献
GENETICS文献大全abstract：:In somatic cells of Drosophila, the ratio of X chromosomes to autosomes (X:A ratio) determines sex and dosage compensation. The present paper addresses the question of whether germ cells also use the X:A ratio for sex determination and dosage compensation. Triploid female embryos were generated which, through the loss...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1985-03-01 00:00:00
abstract：:There are two naturally occurring functional alleles of the recombination hotspot cog, which is located 3.5 kb from the his-3 locus of Neurospora crassa. The presence of the cog+ allele in a cross significantly increases recombination in the his-3 region compared to a cross homozygous for the cog allele. Data obtained...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.103.025080
更新日期：2004-07-01 00:00:00
abstract：:The r-X1 deficiency in maize induces nondisjunction at the second mitotic division during embryo sac formation. However, it was not known if this deficiency also induces nondisjunction during the microspore divisions. Microsporogenesis in plants lacking or containing this deficiency was compared using two approaches. ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:Wolbachia-induced cytoplasmic incompatibility (CI) is expressed when infected males are crossed with either uninfected females or females infected with Wolbachia of different CI specificity. In diploid insects, CI results in embryonic mortality, apparently due to the the loss of the paternal set of chromosomes, usuall...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.086488
更新日期：2008-04-01 00:00:00
abstract：:The conserved histone variant H2A.Z fulfills many functions by being an integral part of the nucleosomes placed at specific regions of the genome. Telomeres cap natural ends of chromosomes to prevent their recognition as double-strand breaks. At yeast telomeres, H2A.Z prevents the spreading of silent chromatin into pr...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.095547
更新日期：2008-12-01 00:00:00
abstract：:Apomixis (asexual seed formation) is the result of a plant gaining the ability to bypass the most fundamental aspects of sexual reproduction: meiosis and fertilization. Without the need for male fertilization, the resulting seed germinates a plant that develops as a maternal clone. This dramatic shift in reproductive ...
journal_title：Genetics
pub_type： 杂志文章,评审
doi：10.1534/genetics.114.163105
更新日期：2014-06-01 00:00:00
abstract：:Dissecting the genes involved in complex traits can be confounded by multiple factors, including extensive epistatic interactions among genes, the involvement of epigenetic regulators, and the variable expressivity of traits. Although quantitative trait locus (QTL) analysis has been a powerful tool for localizing the ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.090175
更新日期：2008-12-01 00:00:00
abstract：:The nonparametric bootstrap approach is known to be suitable for calculating central confidence intervals for the locations of quantitative trait loci (QTL). However, the distribution of the bootstrap QTL position estimates along the chromosome is peaked at the positions of the markers and is not tailed equally. This ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2002-04-01 00:00:00
abstract：:A novel method of RNA secondary structure prediction based on a comparison of nucleotide sequences is described. This method correctly predicts nearly all evolutionarily conserved secondary structures of five different RNAs: tRNA, 5S rRNA, bacterial ribonuclease P (RNase P) RNA, eukaryotic small subunit rRNA, and the ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2000-02-01 00:00:00
abstract：:In S. commune the frequency of recombination between the two subunits, alpha and beta, of the B incompatibility factor is genetically controlled. Analysis of the progeny obtained from crosses between high- and low-recombining strains indicates that the gene controlling recombination frequency in the B factor is linked...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1973-05-01 00:00:00
abstract：:Lineage specification in early development is the basis for the exquisitely precise body plan of multicellular organisms. It is therefore critical to understand cell fate decisions in early development. Moreover, for regenerative medicine, the accurate specification of cell types to replace damaged/diseased tissue is ...
journal_title：Genetics
pub_type： 杂志文章,评审
doi：10.1534/genetics.119.302661
更新日期：2019-12-01 00:00:00
abstract：:A subset of cancers rely on telomerase-independent mechanisms to maintain their chromosome ends. The predominant "alternative lengthening of telomeres" pathway appears dependent on homology-directed repair (HDR) to maintain telomeric DNA. However, the molecular changes needed for cells to productively engage in telome...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.119.302606
更新日期：2019-10-01 00:00:00
abstract：:Genetic adaptation to external stimuli occurs through the combined action of mutation and selection. A central problem in genetics is to identify loci responsive to specific selective constraints. Many tests have been proposed to identify the genomic signatures of natural selection by quantifying the skew in the site ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.113.152587
更新日期：2013-09-01 00:00:00
abstract：:Great interest was aroused by reports, based on microsatellite markers, of high levels of statistically significant long-range and nonsyntenic linkage disequilibrium (LD) in livestock. Simulation studies showed that this could result from population family structure. In contrast, recent SNP-based studies of livestock ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.097402
更新日期：2009-02-01 00:00:00
abstract：:An elevated mutation rate can provide cells with a source of mutations to adapt to changing environments. We identified a negative epistatic interaction involving naturally occurring variants in the MLH1 and PMS1 mismatch repair (MMR) genes of Saccharomyces cerevisiae We hypothesized that this MMR incompatibility, cre...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.116.199513
更新日期：2017-04-01 00:00:00
abstract：:During meiotic prophase, assembly of the synaptonemal complex (SC) brings homologous chromosomes into close apposition along their lengths. The Zip1 protein is a major building block of the SC in Saccharomyces cerevisiae. In the absence of Zip1, SC fails to form, cells arrest or delay in meiotic prophase (depending on...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.071100
更新日期：2007-06-01 00:00:00
abstract：:Circadian clocks organize the metabolism, physiology, and behavior of organisms throughout the day-night cycle by controlling daily rhythms in gene expression at the transcriptional and post-transcriptional levels. While many transcription factors underlying circadian oscillations are known, the splicing factors that ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.117.300139
更新日期：2017-10-01 00:00:00
abstract：:A multivariate quantitative genetic model is analyzed that is based on the assumption that the genetic variation at a locus j primarily influences an underlying physiological variable yj, while influence on the genotypic values is determined by a kind of "developmental function" which is not changed by mutations at th...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：:Frequent nonhomologous recombination has been previously postulated to explain the 1045-bp insertion in one mitochondrial sperm-transmitted haplotype of Mytilus galloprovincialis. Such recombination would lead to the disruption of gene order and so the existence of a specific mechanism for maintaining the same gene or...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.065698
更新日期：2007-02-01 00:00:00
abstract：:Microarray experiments have been used recently in genetical genomics studies, as an additional tool to understand the genetic mechanisms governing variation in complex traits, such as for estimating heritabilities of mRNA transcript abundances, for mapping expression quantitative trait loci, and for inferring regulato...
journal_title：Genetics
pub_type： 杂志文章,评审
doi：10.1534/genetics.106.057281
更新日期：2006-10-01 00:00:00
abstract：:The distribution of genetic polymorphisms in a population contains information about evolutionary processes. The Poisson random field (PRF) model uses the polymorphism frequency spectrum to infer the mutation rate and the strength of directional selection. The PRF model relies on an infinite-sites approximation that i...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.087361
更新日期：2008-12-01 00:00:00
abstract：:The spatial model of Levene (1953) was examined in a finite population and compared to a temporal model. The spatial model was much more effective in retaining genetic variation in a finite population. Furthermore, the haploid spatial model was more effective in retaining genetic variation than the analogous diploid a...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1978-06-01 00:00:00
abstract：:Persistence time of a mutant allele, the expected number of generations before its elimination from the population, can be estimated as the ratio of the number of segregating mutations per individual over the mutation rate per generation. We screened two natural populations of Drosophila melanogaster for mutations cau...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.046094
更新日期：2005-12-01 00:00:00
abstract：:In the yeast Saccharomyces cerevisiae, rim1, 8, 9, or 13 mutations cause four phenotypes: poor growth at low temperature, altered colony morphology, inefficient sporulation due to reduced expression of the meiotic activator IME1, and, as shown here, defective invasive growth. In this report, we have determined the rel...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:The fine-scale pattern of correlated paternity was characterized within a population of the narrow-endemic model plant species, Centaurea corymbosa, using microsatellites and natural progeny arrays. We used classical approaches to assess correlated mating within sibships and developed a new method based on pairwise ki...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.027714
更新日期：2004-11-01 00:00:00
abstract：:The involvement of Schizosaccharomyces pombe prm1(+) in cell fusion during mating and its relationship with other genes required for this process have been addressed. S. pombe prm1Δ mutant exhibits an almost complete blockade in cell fusion and an abnormal distribution of the plasma membrane and cell wall in the area ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.113.159558
更新日期：2014-04-01 00:00:00
abstract：:Though much has been learned about the process of ovarian follicle maturation through studies of oogenesis in both vertebrate and invertebrate systems, less is known about how follicles form initially. In Drosophila, two somatic follicle stem cells (FSCs) in each ovariole give rise to all polar cells, stalk cells, and...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.109.109538
更新日期：2010-02-01 00:00:00
abstract：:Promoter proximal pausing (PPP) of RNA polymerase II has emerged as a crucial rate-limiting step in the regulation of gene expression. Regulation of PPP is brought about by complexes 7SK snRNP, P-TEFb (Cdk9/cycT), and the negative elongation factor (NELF), which are highly conserved from Drosophila to humans. Here, we...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.120.303419
更新日期：2020-09-01 00:00:00
abstract：:Two protocols are presented that allow the selection of mutations mapping to micronuclear chromosome 5 in Tetrahymena thermophilia. One protocol involves crossing mutagenized diploid cells directly to a strain nullisomic for chromosome 5 and screening the monosomic progeny for a mutant phenotype. The second protocol f...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
abstract：:Mutant alleles of two genetic regulatory elements, which underlie a three- to sixfold reduction in beta-glucuronidase (GUS) activity levels, distinguish mice of the H haplotype from those of the other two common GUS haplotypes, A and B. Both elements are tightly linked to the GUS structural gene over which they exert ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
