Abstract:
:Several data indicate that the activation of oncogenes and growth factors as well as inactivation of the tumor suppressor genes are implicated in the development of human neoplasms, including sarcomas. In the present study we described a case of the extremely rare, but highly malignant neoplasm of the female genital tract known as sarcoma botryoides of the uterine cervix and assessed, using molecular and an immunohistochemical analysis, p53 and K-ras alterations in the tumor. A point mutation in exon 6 of the p53 tumor suppressor gene was found but no K-ras gene point mutations at codons 12, 13 and 61 were detected using molecular analysis. p53 protein was overexpressed in more than half of the neoplastic cells, however, ras p21 protein expression was not immunohistochemically detected. Our data indicate that p53, but not K-ras gene alterations may play a role in the development and progression of sarcoma botryoides of the uterine cervix.
journal_name
Eur J Gynaecol Oncoljournal_title
European journal of gynaecological oncologyauthors
Semczuk A,Baranowski W,Berbeć H,Marzec B,Skomra D,Miturski Rkeywords:
subject
Has Abstractpub_date
1999-01-01 00:00:00pages
311-4issue
4eissn
0392-2936issn
2709-0086journal_volume
20pub_type
杂志文章abstract::This study deals with the monitoring of plasmatic levels of malondialdehyde, as the main indicator of oxidative damage to biomembranes. Malondialdehyde is determined by high-performance liquid chromatography (HPLC) after derivatization employing 2,4-dinitrophenylhydrazine. A clinical study involving 20 female patients...
journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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更新日期:2007-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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更新日期:1982-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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doi:
更新日期:1988-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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更新日期:1990-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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更新日期:2010-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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doi:
更新日期:1996-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2017-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章,评审
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journal_title:European journal of gynaecological oncology
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更新日期:1999-01-01 00:00:00
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更新日期:2003-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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更新日期:2002-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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doi:
更新日期:2005-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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更新日期:2014-01-01 00:00:00
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