The effect of vitamin E on plasmatic malondialdehyde levels during surgical removal of ovarian and endometrial carcinomas.

Abstract:

:This study deals with the monitoring of plasmatic levels of malondialdehyde, as the main indicator of oxidative damage to biomembranes. Malondialdehyde is determined by high-performance liquid chromatography (HPLC) after derivatization employing 2,4-dinitrophenylhydrazine. A clinical study involving 20 female patients suffering from ovarian and endometrial carcinomas has demonstrated elevated levels of malondialdehyde (10.1 +/- 1.1 microM), compared with the control group (7.5 +/- 2.7 microM). It has been further verified that surgical removal of the tumor leads to an additional increase in the plasmatic malondialdehyde content. This unfavourable situation can be effectively eliminated by administration of a single dose of vitamin E prior to surgery.

journal_name

Eur J Gynaecol Oncol

authors

Matejcková J,Samec M,Samcová E,Rokyta R,Tůma P

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

329-31

issue

4

eissn

0392-2936

issn

2709-0086

journal_volume

34

pub_type

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