Abstract:
:Reports on the detection of genome human papillomaviruses (HPV) in genital neoplasia differ to a great extent either in the overall prevalence or in the frequency of certain types. The aim of the study was to determine the correlation between the HPV infection and the occurrence of premalignant and malignant diseases of the uterine cervix and to investigate the ratio between clinical features and infection findings starting from the assumption that infection by human papillomaviruses is a key factor in the occurrence of premalignant and malignant disease of the uterine cervix. The investigation was carried out on 48 patients who formed the study group (Group I). Based on suspicious colposcopy findings, a Papanicolaou (Pap) smear and biopsy were performed and a histopathological analysis of the sample was carried out. A cervical smear was done on all the patients for HPV detection and typing. The patients in whom HPV infection was not found formed a control group (C Group). In spite of certain divergences it has not been proved that the ratio between colposcopy findings and HPV type has any statistical importance (chi2 = 3.305; p > 0.05). The distribution of Pap smear results did not shown a significant difference with respect to HPV type (chi2 = 0.105; p > 0.05). When the data are analyzed the diagnosis of low-grade squamous intraepithelial lesions (LGSIL) is evident in 20% of the HPV cases whereas it is significantly lower with respect to the group where HPV was not detected (42.5%). Histopathological (HP) findings of a high-grade squamous intraepithelial lesions (HGSIL) in both groups are diagnosed in approximately the same percentage while 6.7% of cancer in situ was registered in the group of HPV positive patients. Based on this it can be concluded that if a diagnosis of LGSIL or HGSIL in particular has been made on the basis of HP findings there is a great probability that the infection was due to one or more joined types of human papillomaviruses.
journal_name
Eur J Gynaecol Oncoljournal_title
European journal of gynaecological oncologyauthors
Perovic M,Berisavac M,Kuljic-Kapulica N,Jovanovic Tkeywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
42-4issue
1eissn
0392-2936issn
2709-0086journal_volume
23pub_type
杂志文章abstract::All malignant cells appear to have increased needs for glucose in vitro as well as in vivo. The enhanced glucose uptake is mediated through transporters (Gluts), whose action and expression are regulated by oncogenes and growth factors. Cyclin D1 is a nuclear protein that plays an important role in regulating the cell...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To assess the relation between expressions of human nonmetastatic clone 23 (nm23-H1) and p53 in cervical cancer, their relationships with lymph node metastasis, and further to examine their predictive of lymph node metastases. MATERIALS AND METHODS:nm23-H1 and p53 expression profiles were visualized by immun...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::Ovarian carcinoma is a malignancy with a poor prognosis especially in patients with advanced disease. The majority of patients with ovarian serous carcinoma are diagnosed in advanced stages. Palpable extraabdominal lymphadenopathy at the time of presentation is distinctly uncommon. This case report addresses a patient...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Vulvar dermatofibrosarcoma is a rare fibrous tumor of intermediate grade malignancy, with a tendency for local recurrence, and rarely metastasizes. Management should be multidisciplinary. This is a report of an apparently benign vulvar mass with delayed diagnosis of vulvar dermatofibrosarcoma. CASE REPORT:A...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the relationship between the hematocrit (HCT), serum erythropoietin (EPO) and insulin-like growth factor-1 (ILGF-1) levels in breast cancer patients receiving non-nephrotoxic chemotherapy. METHODS:Seventeen patients with stage II breast cancer were included. All received 6 cycles of non-nephrotox...
journal_title:European journal of gynaecological oncology
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Endometrial adenocarcinoma is the most common malignant neoplasm of the female genital tract and, despite its relative frequency, the molecular events that contribute to the development and progression of the lesion remain poorly understood. The normal human endometrium is characterized by hormone-dependent variations...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
abstract::Ten patients with Sertoli-Leydig cell tumors of the ovary treated consecutively were analyzed retrospectively for clinicopathological characteristics, treatment modalities and survival. All patients were subjected to a surgical procedure including unilateral salpingoophorectomy (USO) in 5, total abdominal hysterectomy...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To establish whether information leaflets and appointment reminders improve attendance for diagnostic colposcopy. DESIGN & SETTING:Randomised controlled trial in an inner city colposcopy clinic. PARTICIPANTS:500 women newly referred to the colposcopy clinic with abnormal cervical screening smear results were ...
journal_title:European journal of gynaecological oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2004-01-01 00:00:00
abstract::The present paper examined the influence of patient age, surgical T stage, tumor size, tumor differentiation and lymphnodal status on the clinical outcome of 29 patients with primary vulvar squamous cell carcinoma treated with radical surgery. Eighteen patients underwent radical vulvectomy with bilateral inguinal-femo...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Ovarian Brenner tumors are rare epithelial tumors that account for 1%-2% of all ovarian neoplasms. They can be subdivided into benign, borderline or proliferative, and malignant neoplasms. In the vast majority of cases, these lesions are benign. Tumors of borderline malignancy are less frequent and only abou...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章,评审
doi:
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:Serous ovarian cancer is the most prevalent type of ovarian cancer. The majority of women present at an advanced stage and patient survival is poor. Resistance to chemotherapy is thought to relate to failure of tumours to undergo apoptosis. Secreted frizzled-related protein 4 (SFRP4) has been demonstrated to ...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2015-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2017-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章,评审
doi:
更新日期:2015-01-01 00:00:00
abstract::The purpose of our study was to examine the concordance among colposcopy, cytology, and histology in the diagnoses of intraepithelial lesions of the uterine cervix. We compared the results of Pap tests, biopsies, and colposcopy in 190 patients, who had histologically proven CIN and/or HPV infection, using histology as...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
abstract::Treatment of Stage IB-IIA cervical carcinoma is controversial. The choice to perform surgery or chemoradiation depends on the FIGO Stage, which does not include evaluation of lymph node involvement, although the prognosis of the patients depends on this evaluation. There is no method however, to safely evaluate preope...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00