Abstract：
BACKGROUND:There is considerable evidence for a higher incidence of uterine sarcomas in blacks when compared to whites. However, whether this higher incidence is related to differences in clinicopathologic presentation is not known. PATIENTS AND METHODS:We reviewed slides and clinical charts of 81 patients with a primary diagnosis of uterine sarcoma referred between 1991 and 1999 to Kalafong Academic and Pretoria Academic Hospital. After review, 49 cases remained for study. RESULTS:Uterine sarcomas were distributed between leiomyosarcoma (LMS) (39%), carcinosarcoma (CS) (49%) and endometrial stromal sarcoma (ESS) (12%). LMS and ESS tend to present at an earlier age when compared to CS (respectively p < 0.008 and 0.02). Of women with LMS more women are premenopausal when compared to CS (p < 0.009). Lower abdominal pain is more common in LMS (p < 0.009), whereas bleeding is more common in women suffering from CS (p < 0.01). Lymphovascular space involvement and cervical involvement are more common in CS when compared to LMS. In CS, the carcinoma component has most of the metastatic potential. CONCLUSION:Among black South African women different clinicopathologic features for uterine LMS, CS and ESS are observed. We also present genetic and/or hormonal factors possibly contributing to the pathophysiology of uterine sarcomas in blacks.
journal_name
Eur J Gynaecol Oncoljournal_title
European journal of gynaecological oncologyauthors
Amant F,Dreyer L,Makin J,Vergote I,Lindeque BGkeywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
194-200issue
3eissn
0392-2936issn
2709-0086journal_volume
22pub_type
杂志文章abstract：PURPOSE OF INVESTIGATION:The purpose of this study was to determine the prevalence of various human papillomavirus (HPV) types and its relationship with some risk factors among Turkish women. MATERIALS AND METHODS:A total of 673 patients were included in the study. Cervical samples were taken from the patients for rou...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2016-01-01 00:00:00
abstract：PURPOSE OF INVESTIGATION:The aim of the study was to determine the activity of cathepsin D (CTSD) and alpha-1-antitrypsin (AAT) in the blood serum of women with cervical carcinoma treated with different modes of therapy. METHODS:The study was conducted on 68 women suffering from carcinoma of the uterine cervix, that w...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:The true struma ovarii is a rare teratomatous neoplasia, composed with typical thyroid tissue. Generally it is asymptomatic or only determines a mild hypogastric weighting feeling. In a few subjects this neoplasm is secreting and rise to hyperthyroidism. The Authors describe the clinical and anatomopathological charac...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:In the under-resourced world, transfusion to advanced oncological patients involves two major problems, i.e., (a) transfusion transmitted disease, and (b) infrastructural deficiency. Many hospitals cannot cope with the specialized requirements of immunocompromised cancer victims, for instance, leucoreduction, selectiv...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVE:In order to determine the significance of proliferative activity (PA) in endometrial carcinomas, we analysed the expression of cell cycle-related antigens in routinely processed tissue. MATERIALS AND METHODS:Serial sections of 113 endometrial carcinoma specimens were immunostained with the monoclonal antibod...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：PURPOSE OF INVESTIGATION:Ovarian cancer is associated with poor prognosis and altered protein expression patterns may be useful for identifying patients likely to have poor disease outcomes. The impact of altered INPP4B protein expression on prognosis is unclear. The aim of this study was to evaluate the implication of...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
abstract：:A case of cervical cancer in a 32-year-old woman with a genotype 6 HPV genital infection that developed from a cervical low-grade SIL after a LLETZ procedure two years before is presented. This case obliges us to reconsider both the benign nature of low-grade lesions and the potentially good prognosis of low-risk HPV ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Estrogen replacement therapy (ERT) has been shown to be of benefit for menopausal women, especially in prevention of coronary heart disease and osteoporotic fractures. Cancer fear is an important obstacle to use of ERT. From our literature review, there is a weak or no association between ERT and ovarian cancer risk. ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
abstract：:In a retrospective study, a total of 120 ovarian cancer patients were paired in terms of staging, grading, patent age, and operative and cytostatic therapy. Half of the patients underwent radioimmunoscintigraphy for diagnostic purposes. From the point of view of possible adjuvant immunological therapy, we investigated...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:A combined modality therapy (irradiation plus low-dose Adriamycin and Cyclophosphamide) was delivered to 41 patient affected by extensive bone diffusion from breast carcinoma. A 36% (15/41) objective response rate was obtained, no change was also detectable in 36%, while progressive disease in 28% (11/41). A subjectiv...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:The mortality rate from cervical cancer has notably decreased above all in those places where aggressive Papanicolaou smear screening programmes have taken place. In other countries, where an organized screening programme has not taken place, there has been an increase in mortality from cervical carcinoma. Beyond the ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Abnormal Uterine Bleeding is a very frequent pathology particularly in perimenopausal age (> or = 45 years). The Authors report the experience of the 2nd Department of Ob/Gyn. of Rome University "La Sapienza" from January 1985 up to September 1991. The hysteroscopic evaluation of 789 patients in perimenopausal age is ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The great importance of knowing the risk factors for breast pathology in order to reveal the risk categories is well known. In many geographical areas breast cancer is the most common female neoplasm. Recent Italian statistics point out that every year 83 women out of 100,000 develop breast cancer and that its inciden...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Aggressive fibromatoses (desmoid tumors) are rare tumors of fibroblastic origin that may arise in any musculoaponeurotic structure with a propensity of infiltrate adjacent tissues, but not to metastasize. Tumors of musculoaponeurotic origin are seldom encountered by the gynecologist. A case of pelvic fibromatosis is r...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:We report seven cases of intravenous leiomyomatosis. Growth beyond the uterus occurred in two of the seven cases in the broad ligament. One 21-year-old patient is one of the youngest reported cases in the literature. Five patients had total abdominal hysterectomy with removal of the adnexa and two patients underwent m...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:The concentration of c-erbB-2 oncoprotein (HER-2/neu) was examined in the membrane fraction of 196 breast cancer and 39 benign breast specimens using a recently introduced ELISA-assay. The results were compared with established clinical and laboratory prognostic factors, 19% of all breast cancer specimens showed a c-e...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVE:Three cases of pelvic actinomycosis initially diagnosed as pelvic malignancy and treated surgically are reported. CASES:The first case was a 38-year-old multiparous woman who was referred to our clinic because of bilateral ovarian solid masses. With the impression of ovarian carcinoma, a laparotomy was perfo...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:The clinicopathologic features of a patient with primary carcinoid tumor of the ovary who presented with the signs of cardiac failure are described. The patient underwent total abdominal hysterectomy + bilateral salpingo-oophorectomy + omentectomy + bilateral pelvic lymphadenectomy + appendectomy; and she is alive wit...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：PURPOSE:Surgical staging in early endometrial cancer is not universally done and lymphadenectomy in early-stage disease is controversial. Aim of the present study was to evaluate surgical staging in patients with endometrioid histology, FIGO Stage IA endometrial cancer. MATERIALS AND METHODS:Eighty-seven patients with...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
abstract：:Insulin-like growth factor-1 receptor (IGF-1R) regulates carcinogenesis and tumor development and is expressed in normal endometrium. Vascular endothelial growth factor C (VEGF-C) promotes lymph node metastasis. We investigated IGF-1R, VEGF-C and D2-40 in endometrial adenocarcinoma and the association between IGF-1R a...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：:The c-erbB-2 proto-oncogene is a gene that encodes a growth factor receptor-like molecule with tyrosine kinase activity. The purpose of this study was to determine whether c-erbB-2 gene amplification measured by the simple and sensitive differential polymerase chain reaction (PCR) method correlates with clinicopatholo...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:Reports on the detection of genome human papillomaviruses (HPV) in genital neoplasia differ to a great extent either in the overall prevalence or in the frequency of certain types. The aim of the study was to determine the correlation between the HPV infection and the occurrence of premalignant and malignant diseases ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
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journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2016-01-01 00:00:00
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journal_title：European journal of gynaecological oncology
pub_type： 杂志文章,评审
doi：
更新日期：2002-01-01 00:00:00
abstract：:We present a case of a 30-year-old pregnant woman in whom an ovarian mass was identified by ultrasonography at 15 weeks' gestation. A markedly elevated maternal serum alphafetoprotein (MSAFP) suggested a diagnosis of endodermal sinus tumour of the ovary. A right salpingo-oophorectomy at 19 weeks' gestation enabled his...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Small cell cancers of the cervix are very rare and aggressive tumours. It is difficult to manage these tumours. They are often diagnosed in an advanced stage and their prognosis is generally poor. There are no clinical trials, due to their rarity, that would suggest optimal treatment. The present report describes a pa...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章,评审
doi：
更新日期：2004-01-01 00:00:00
abstract：:All malignant cells appear to have increased needs for glucose in vitro as well as in vivo. The enhanced glucose uptake is mediated through transporters (Gluts), whose action and expression are regulated by oncogenes and growth factors. Cyclin D1 is a nuclear protein that plays an important role in regulating the cell...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:The aim of the pilot study was to assess the feasibility, efficacy, and accuracy of the sentinel lymph node biopsy (SLNB) procedure in vulvar cancer. PATIENTS AND METHODS:From February 2003 to March 2007, 17 patients with vulvar cancer, clinical Stages I and II, underwent SLN (sentinel lymph node) detection...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：:The efficacy of a new device, "the Endopap" endometrial cell sampler in obtaining specimens for cytological examination to detect precursors of malignancy of the endometrium was assessed in 140 asymptomatic and sympomatic women. The cytological results as compared with hystological diagnosis on curettage specimens by ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:Ovarian Brenner tumors are rare epithelial tumors that account for 1%-2% of all ovarian neoplasms. They can be subdivided into benign, borderline or proliferative, and malignant neoplasms. In the vast majority of cases, these lesions are benign. Tumors of borderline malignancy are less frequent and only abou...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
