Abstract:
PURPOSE OF INVESTIGATION:Infertility represents one of the main sequelae of cytotoxic therapy given for various malignant diseases. Because dividing cells are more sensitive to cytotoxic effects than are cells at rest, it has been hypothesized that inhibition of the pituitary-gonadal axis may facilitate the preservation of future gonadal function. The aim of our study was to find a quick, reliable and economic way to suppress the pituitary-gonadal axis by combining GnRH-agonists with GnRH-antagonists in order to preserve future gonadal function. METHODS:A combination of D-Trp6-GnRH-a (3.75 mg) and cetrorelix (3 mg) was used to achieve a quick downregulation in six postmenarchal young women (aged 15.4 +/- 0.7) years with haematological malignancies before the onset of cytotoxic chemotherapy. RESULTS:The combination of D-Trp6-GnRH-a and GnRH-antagonist cetrorelix induced a reliable and long-lasting suppression of gonadotrophin secretion within 96 hours in all patients allowing cytotoxic therapy to be started without any delay. CONCLUSIONS:The combination of GnRH-agonist and GnRH-antagonist enables a rapid, reliable and cost-effective suppression of the pituitary-gonadal axis to be achieved. Future gonadal function of treated patients will be monitored.
journal_name
Eur J Gynaecol Oncoljournal_title
European journal of gynaecological oncologyauthors
Mardesic T,Snajderova M,Sramkova L,Keslova P,Sedlacek P,Stary Jkeywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
90-2issue
1eissn
0392-2936issn
2709-0086journal_volume
25pub_type
杂志文章abstract:BACKGROUND:Only a few renin-producing ovarian tumors have been reported, and most such ovarian tumors have been sex cord/stromal tumors. Renin-producing ovarian epithelial tumors are quite rare. CASE:A 46-year-old woman presented with hypertension and hypokalemia. Examinations of the patient revealed elevated plasma r...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::Ninety-two cases of primary carcinoma of the vagina treated at the Massachusetts General Hospital were reviewed from 1961 to 1981. Forty patients were found to have recurrence. Their original clinical stage, location of lesion, histologic subtype, tumor differentiation, and treatment modality were examined to predict ...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
abstract:PURPOSE:To determine the safety of omitting routine interval laboratory assessments, dietary restrictions, and isolation precautions between cycles of chemotherapy for gynecologic malignancies. METHODS:Data were retrospectively obtained from the records of women receiving chemotherapy for gynecologic cancer from July ...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract:INTRODUCTION:Methylation of genomic DNA is one of the major mechanisms that deactivates genes and regulates their tissue-specific transcription levels. Its patterns are based on clonal inheritance that occurs in the early stages of embryogenesis. All changes in the DNA methylation levels occurring especially in the pro...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章,评审
doi:
更新日期:2004-01-01 00:00:00
abstract::Papillary serous adenocarcinoma of the endocervix (PSAE) is a rarely encountered neoplasm. The literature includes only a limited number of well documented case studies. The present study reports a case of papillary serous adenocarcinoma originating from the endocervix. ...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-01 00:00:00
abstract::The incidence of invasive cervical cancer and consequently mortality decreased due to adequate screening programmes in Canada from 1969 to 2003. Systematic cervical screening programmes similar to those in Europe should be implemented throughout Canada. The new techniques, including a liquid-based cytology, associated...
journal_title:European journal of gynaecological oncology
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更新日期:2004-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
abstract:AIM:To present the classification and diagnostic problems encountered between teratomas and other ovarian tumors as well as with other benign entities diagnosed and treated in our institution. METHODS:We analysed retrospectively the clinical and pathological characteristics of 87 teratomas examined in our hospital dur...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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更新日期:2005-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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更新日期:2006-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::Serous psammocarcinoma is a rare form of ovarian carcinoma characterized by massive psammoma body formation. We report a new case of aggressive ovarian psammocarcinoma with omental and peritoneal implants. ...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2016-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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doi:
更新日期:2012-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2011-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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doi:
更新日期:2009-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::In to order to investigate the prevalence of HPV related parameters in sexually non-active women, smears of 75 virgins were microscopically reviewed for alterations caused by HPV i.e. koilocytosis, parakeratosis and multinucleinization. In none of these smears were the mentioned parameters seen together, so the diagno...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
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