Effective chemoradiotherapy protocol with 5-fluorouracil for cervical squamous cell carcinoma in vitro.

Abstract:

PURPOSE OF INVESTIGATION:5-Fluorouracil (5FU) is frequently used in concurrent chemoradiotherapy for patients with advanced cervical cancer, although its optimal chemoradiotherapy protocol has not yet been established. In search of an optimal chemoradiotherapy protocol, some in vitro experiments were carried out. METHODS:The radiosensitive human cervical squamous cell carcinoma cell line ME180 was examined to investigate the effects of 5FU on radiosensitivity and the effects of irradiation on 5FU-sensitivity. RESULTS:5FU dose-dependently enhanced cellular radiosensitivity at therapeutic concentrations. Although high doses of y-ray irradiation significantly reduced the 5FU-sensitivity, a low dose of irradiation at therapeutic doses (< 2.5 Gy) had no effect on 5FU-sensitivity of the irradiated cells. Cells pretreated with 5FU eight hours before irradiation showed significantly higher 5FU-sensitivity than cells concurrently treated with 5FU and irradiation. In contrast, cells treated with 5FU eight hours after irradiation showed significantly lower 5FU-sensitivity than cells concurrently treated with 5FU and irradiation. Moreover, all four post-irradiation surviving subclones obtained from repeatedly irradiated ME180 cells showed significantly lower 5FU-sensitivity than the non-irradiated parent cells. CONCLUSION:5FU acts as a radiosensitizer for cervical squamous cell carcinoma and 5FU-sensitivity is reduced in irradiated cells. Therefore, 5FU administration immediately before irradiation may be a more effective treatment than concurrent chemoradiotherapy or post-irradiation chemotherapy with 5FU.

journal_name

Eur J Gynaecol Oncol

authors

Tanaka T,Yukawa K,Umesaki N

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

243-6

issue

3

eissn

0392-2936

issn

2709-0086

journal_volume

27

pub_type

杂志文章
  • Management of ovarian cysts in pregnancy: a case report.

    abstract::According to recent epidemiological studies on ovarian cysts during pregnancy one out of 600 are, in most cases, benign neoformations. The most frequent histological type reported is mature cystic teratoma (50% of the cases), followed by functional cysts (13%), benign cystadenomas (20%) and ovarian cancer (0.6%). Most...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Patacchiola F,Collevecchio N,Di Ferdinando A,Palermo P,Di Stefano L,Mascaretti G

    更新日期:2005-01-01 00:00:00

  • Exaggerated placental site mimicking placental site trophoblastic tumor: case report and literature review.

    abstract::Exaggerated placental site is defined as a non-neoplastic trophoblastic lesion featuring exuberant infiltration into the endometrium and myometrium by intermediate trophoblasts and syncytiotrophoblasts. Exaggerated placental site can occur following normal or ectopic pregnancy, abortion, or hydatidiform mole. We encou...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Yeasmin S,Nakayama K,Katagiri A,Ishikawa M,Iida K,Nakayama N,Miyazaki K

    更新日期:2010-01-01 00:00:00

  • Dedifferentiated endometrioid adenocarcinoma of the uterus: a case report.

    abstract:BACKGROUND:Dedifferentiated endometrioid adenocarcinoma (DEAC) of the uterus was first described by Silva et al. in 2006. The tumor has high-grade endometrial carcinoma component which abruptly emerged from low-grade areas. DEAC showed more aggressive phenotype than FIGO grade 3 endometrioid adenocarcinoma. However, th...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Soyama H,Takano M,Miyamoto M,Kato M,Goto T,Furuya K

    更新日期:2016-01-01 00:00:00

  • Extramedullary hematopoiesis in the uterine isthmus: a case report and review of the literature.

    abstract::Extramedullary hematopoiesis (EH) is the ectopic production of myeloid, erythroid and megakaryocytic elements. In postfetal life it usually occurs in conditions with hyperactive, depleted or infiltrated marrow; it is extremely rare in the genital tract. We report a case of EH in the uterine isthmus (UI) which was foun...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Varras M,Stylianido A,Akrivis Ch,Galanis P,Stefanaki S,Antoniou N

    更新日期:2002-01-01 00:00:00

  • Prognostic value of INPP4B protein immunohistochemistry in ovarian cancer.

    abstract:PURPOSE OF INVESTIGATION:Ovarian cancer is associated with poor prognosis and altered protein expression patterns may be useful for identifying patients likely to have poor disease outcomes. The impact of altered INPP4B protein expression on prognosis is unclear. The aim of this study was to evaluate the implication of...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Salmena L,Shaw P,Fans I,McLaughlin,Rosen B,Risch H,Mitchell C,Sun P,Narod SA,Kotsopoulos J

    更新日期:2015-01-01 00:00:00

  • Immunoperoxidase localization of HSV2 antigens in cervical dysplasia and carcinoma.

    abstract::The AA. have evaluated by means of the immunohistochemical technique the incidence of herpetic phlogosis in 76 women with neoplastic pathologies of the uterine cervix. The patients were submitted to cytologic, colposcopic and histologic examination for CIN. The HSV2 positivity by immunohistochemical method was demonst...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Setzu A,Puligheddu P,Marcello C,Parodo G,Liguori C,Zucca A,Lecca U

    更新日期:1987-01-01 00:00:00

  • Successful treatment of a persistent mole with myometrial invasion by direct injection of methotrexate.

    abstract::For patients with persistent or invasive gestational trophoblastic disease (GTD), systemic injection of chemotherapy is the treatment of choice if fertility is to be preserved. To prevent serious adverse effects after systemic use and possibly achieve better effects, direct local injection of chemotherapy into the tum...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Su WH,Wang PH,Chang SP

    更新日期:2001-01-01 00:00:00

  • Presentation of a patient with in situ amelanotic melanoma of the vulva.

    abstract::Amelanotic malignant melanoma of the vulva is extremely rare. The authors describe here a case of amelanotic malignant melanoma of the vulva, occurring in a 71-year-old woman without any clinical symptoms. The woman had a small nodular lesion in the left labia majora. Local excision was performed. Histological examina...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Tsikouras P,Galazios G,Tsagias N,Koukoulomati A,Romanidis K,Giatromanolaki A,Sivridis E

    更新日期:2016-08-01 00:00:00

  • Protective and sensitive effects of melatonin combined with adriamycin on ER+ (estrogen receptor) breast cancer.

    abstract:OBJECTIVE:This study aims to investigate the protective and sensitive effects of melatonin (MLT) in the treatment of breast cancer. MATERIALS AND METHODS:ER+ breast cancer rat model was established and then rats were randomly divided into five different groups as follows: control group, Diss group, adriamycin (ADM) gr...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Ma C,Li LX,Zhang Y,Xiang C,Ma T,Ma ZQ,Zhang ZP

    更新日期:2015-01-01 00:00:00

  • Studies on leptin and leptin receptor gene expression in myometrium and uterine myomas of gnRH analogue-treated women.

    abstract:AIM:To test if treatment with GnRH analogue, which leads to a significant reduction in myoma volume, changes expression of leptin genes and gene coding leptin receptor isoforms in uterine myomas and in the surrounding unaltered myometrium. METHODS:Using RT-PCR, expression of leptin genes and leptin receptor genes was ...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Markowska A,Rucinski M,Drews K,Malendowicz LK

    更新日期:2006-01-01 00:00:00

  • Primary ovarian carcinosarcoma: a case report and review of the literature.

    abstract::Primary ovarian carcinosarcoma is characterized by an admixture of malignant epithelial and stromal elements. This neoplasm is extremely rare with fewer than 400 cases reported in the English literature. Its histogenesis, clinical features and optimal treatment remain unclear because of the rarity of primary ovarian c...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Varras M,Akrivis Ch,Antoniou N,Tolis C,Stefanaki S,Salamalekis E

    更新日期:2004-01-01 00:00:00

  • Adjuvant radiotherapy in Stage I endometrial cancer. Where do we stand?

    abstract::This paper reviews the anatomical spread and failure patterns of surgical Stage I endometrial cancer. The controversial aspects of the optimal adjuvant treatment are presented. An attempt is made to identify the most effective management approach based on the pertinent literature data. ...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Petnehazi C,Thirion P,Armstrong J

    更新日期:2003-01-01 00:00:00

  • Primitive omental leiomyoma: a case report.

    abstract::Primitive omental leiomyomas are very rare. The primitive omental location of the leiomyoma is quite difficult to determine, with the possible presence of "parasite" myomas and of omental metastasizing myomas. Moreover, omental masses may be primitive or secondary metastasis from neoplasms. In this case report a primi...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Indraccolo SR,Matteo M,Indraccolo U,Greco P

    更新日期:2014-01-01 00:00:00

  • Primary invasive vaginal cancer. Report of 12 cases.

    abstract::The aim of this study was to describe the clinical features, methods of treatment and results of treatment among patients with primary invasive cancer. Twelve women in whom primary invasive cancer of the vagina was diagnosed between 1996 and 2001 were studied. The mean age of women with primary invasive vaginal cancer...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Diakomanolis E,Rodolakis A,Stefanidis K,Haidopoulos D,Blachos G,Kavalakis J,Michalas S

    更新日期:2002-01-01 00:00:00

  • Primary endometrial B-cell lymphoma: case report.

    abstract::The female genital tract is usually involved with lymphoma as part of disseminated disease. Primary lymphoid neoplasms of the female genital tract are rare; the frequency was reported to be 2% among extranodal lymphomas in women. Most of the time, primary female genital tract lymphoma occurs in the ovary and cervix, w...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Lemos S,Magalhães E,Sousa V,Dias M,de Oliveira C

    更新日期:2008-01-01 00:00:00

  • Neoadjuvant chemotherapy in ovarian cancer.

    abstract::Patients with advanced ovarian cancer have a chance of less than 50% after radical debulking surgery. In spite of the currently more effective combination chemotherapy agents that have become available as adjuvant therapy in the last decade, the prognosis of patients with residual tumor mass larger than 1 cm in diamet...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Camci C,Balat O

    更新日期:2002-01-01 00:00:00

  • Renin-producing serous cystoadenocarcinoma of the ovary: a case report.

    abstract:BACKGROUND:Only a few renin-producing ovarian tumors have been reported, and most such ovarian tumors have been sex cord/stromal tumors. Renin-producing ovarian epithelial tumors are quite rare. CASE:A 46-year-old woman presented with hypertension and hypokalemia. Examinations of the patient revealed elevated plasma r...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Iwamoto H,Hirata S,Honda T,Fukasawa H,Kimura N,Hoshi K

    更新日期:2002-01-01 00:00:00

  • The absence of human papilloma virus (HPV) related parameters in sexually non-active women.

    abstract::In to order to investigate the prevalence of HPV related parameters in sexually non-active women, smears of 75 virgins were microscopically reviewed for alterations caused by HPV i.e. koilocytosis, parakeratosis and multinucleinization. In none of these smears were the mentioned parameters seen together, so the diagno...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Peters AA,Trimbos JB

    更新日期:1994-01-01 00:00:00

  • Establishment of a visualized nude mouse model of cervical carcinoma with high potential of lymph node metastasis via total orthotopic transplantation.

    abstract:OBJECTIVE:To screen cervical carcinoma (CC) SiHa subgroups with high potential of lymphatic metastasis and establish a visualized nude mouse model of cervical carcinoma with a total orthotopic transplantation approach. METHODS:A cervical carcinoma SiHa subgroup with high potential of lymphatic metastasis was isolated ...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Duan P,Duan G,Liu YJ,Zheng BB,Hua Y,Lu JQ

    更新日期:2012-01-01 00:00:00

  • Increased AFP as an indicator of ovarian carcinoma and fetal kidney carcinoma--case report.

    abstract::We examined a young primipara with increased alpha-fetoprotein (AFP) values and cystic tumefaction of the right ovary. Having in mind a mild decrease in ovarian artery resistance index (RI) and suspected findings of fetal kidney, this situation was delicate due to its double pathology which was later confirmed. Wilms'...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Filimonovic D,Gojnic M,Arsenijevic Lj,Popovic N,Dugalic V

    更新日期:2007-01-01 00:00:00

  • Computerized tomography (CT) semeiotics in the presurgical evaluation of gynaecological neoplasias.

    abstract::Computerized tomography has been introduced in studies concerning neoplastic pathology of the pelvis. In this study, we have attempted to define a series of radiological signs, resulting from CT tests of pelvis or abdomen in patients with gynaecological tumors, each of which corresponds to a particular anatomopatholog...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Michelassi PL,Facchini V,Gadducci A,Malventi M,Morelli G,Lazzeri M,Del Bravo B,Calderazzi A,Fioretti P

    更新日期:1985-01-01 00:00:00

  • Optimal variants of treatment of stage I endometrial carcinoma and its choice.

    abstract::2195 patients affected by endometrial carcinoma were treated at the Tbilisi and the St. Petersburg Oncological Institutes from 1968 to 1987. The incidence of different stages was respectively: I 78.8%; II 11.6%; III 9.0%; IV 0.4%. Adenocarcinoma was the histotype more frequently observed and the grade of differentiati...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Charkviani TL

    更新日期:1993-01-01 00:00:00

  • Cervical cancer in Khon Khaen University Hospital, Thailand 1985-1990.

    abstract::From 1985 to 1990, 3040 patients with carcinoma of the uterine cervix were diagnosed and treated at Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Thailand. The epidemiological aspects including ages and geographical distributions, histology, stages, treatment and outcome were presented and compared ...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Pengsaa P,Vatanasapt V,Sri-Amporn S,Udomthavornsuk B

    更新日期:1993-01-01 00:00:00

  • Definitive and palliative radiotherapy for cervix cancer in the elderly.

    abstract::The elderly population is increasing in number. Aggressive therapeutic intervention in this patient group may not always be possible because of age, the presence of co-morbidity, and poor functional status. Hence, individualized management of cervix cancer (CC) in the elderly is often practiced. Because of the precedi...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Ampil FL,Unger JB,Caldito G,Charrier A

    更新日期:2006-01-01 00:00:00

  • Virchow's node as a first manifestation of ovarian serous carcinoma: case report.

    abstract::Ovarian carcinoma is a malignancy with a poor prognosis especially in patients with advanced disease. The majority of patients with ovarian serous carcinoma are diagnosed in advanced stages. Palpable extraabdominal lymphadenopathy at the time of presentation is distinctly uncommon. This case report addresses a patient...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Cebesoy FB,Balatt O,Aydin A

    更新日期:2008-01-01 00:00:00

  • LDH and LDH isoenzymes in ovarian dysgerminoma.

    abstract::Lactic Dehydrogenase (LDH) serum levels were evaluated in three patients with ovarian dysgerminoma and LDH isoenzymes only in one of them. LDH serum levels were elevated at diagnosis and normal after therapy in all the patients; remained low in two patients in remission, increased in one at the moment of progression. ...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Levato F,Martinello R,Campobasso C,Porto S

    更新日期:1995-01-01 00:00:00

  • Meta-analysis of chemotherapy regimens for ovarian carcinoma: a reassessment of cisplatin, cyclophosphamide and doxorubicin versus cisplatin and cyclophosphamide.

    abstract:OBJECTIVE:To compare three year survival, median survival and improved longevity with the addition of doxorubicin to a chemotherapy regimen of cisplatin and cyclophosphamide used in the treatment of ovarian cancer and to integrate this with a previous meta-analysis that compared three year survival. METHODS:Twenty-thr...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章,meta分析

    doi:

    authors: West RJ,Zweig SF

    更新日期:1997-01-01 00:00:00

  • Tamoxifen and endometrial cancer: new data for an old problem. Review.

    abstract::Tamoxifen, a nonsteroidal antiestrogen, is used for pre- and postmenopausal patients with breast cancer. Data on a possible association of endometrial pathologies with Tamoxifen treatment have been accumulating. The current literature and our experience are presented. ...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Leo L,Tessarolo M,Febo G,Farina C,Nuzzo L,Arduino S,Wierdis T,Lanza A

    更新日期:1997-01-01 00:00:00

  • The immune response in malignant ovarian neoplasms.

    abstract::The objective of this study was to review studies that have investigated the immune response in the presence of a malignant ovarian neoplasia. A review of the literature was performed to identify studies of malignant ovarian neoplasia, particularly studies that addressed the potential for cytokines, nitric oxide, and ...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Martins Filho A,Jammal MP,Nomelini RS,Murta EF

    更新日期:2014-01-01 00:00:00

  • Biological significance of plasminogen activator inhibitor-1 expression in ovarian clear cell adenocarcinoma.

    abstract:PURPOSE:Ovarian clear cell adenocarcinoma (OCCA) has been reported to display different characteristics from other histological types of epithelial ovarian cancer, and especially differs from serous adenocarcinoma. We investigated plasminogen activator inhibitor-1 (PAI-1) expression in patients with OCCA and attempted ...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Komiyama S,Aoki D,Saitoh E,Komiyama M,Udagawa Y

    更新日期:2011-01-01 00:00:00