Mitomycin C in higher risk trabeculectomy: a prospective comparison of 0.2- to 0.4-mg/cc doses.

Abstract:

PURPOSE:This randomized, masked, prospective study was conducted to compare the outcome of filtering surgery using doses of 0.2 mg/cc or 0.4 mg/cc of mitomycin C (MMC) in eyes that were at higher risk from previous conjunctival incisional surgery. METHODS:Eyes of 50 consecutive patients with primary open-angle, pseudoexfoliation, or pigmentary glaucoma requiring trabeculectomy who had previously undergone either limbal cataract surgery or trabeculectomy were enrolled. Patients received an intraoperative dose of either 0.2 or 0.4 mg/cc MMC for 2 minutes (n = 25 in each study group). Intraocular pressure (IOP), logMAR visual acuity, and complications were monitored at regular intervals for 1 year. Unpaired student t tests were used to compare percent decrease in IOP in both study groups at each interval. RESULTS:The percent decrease in IOP was not significantly different between groups at 1 day, 1 week, 1 month, 3 months, 6 months, or 1 year after surgery. LogMAR visual acuity was not significantly different between groups at 1 month, 6 months, or 1 year. Treatment failure occurred in seven patients in the 0.2 mg/cc group (28%) and seven patients in the 0.4 mg/cc group (29.2%). Postoperative hypotony, choroidal effusions and hemorrhages, and wound leaks occurred in both groups, but occurred more often in the group receiving 0.4 mg/cc MMC. CONCLUSION:Filtering surgery performed on higher risk eyes was as effective using a lower dose (0.2 mg/cc) of MMC as that using a higher dose (0.4 mg/cc). Incidence of complications and treatment failures was slightly higher in the group receiving high-dose MMC.

journal_name

J Glaucoma

journal_title

Journal of glaucoma

authors

Sanders SP,Cantor LB,Dobler AA,Hoop JS

keywords:

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

193-8

issue

3

eissn

1057-0829

issn

1536-481X

journal_volume

8

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章

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    journal_title:Journal of glaucoma

    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章

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    doi:

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    更新日期:1999-08-01 00:00:00

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    更新日期:2009-08-01 00:00:00

  • The Glaucoma Italian Pediatric Study (GIPSy): 1-Year Results.

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    journal_title:Journal of glaucoma

    pub_type: 杂志文章,多中心研究,随机对照试验

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    pub_type: 杂志文章,多中心研究

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    journal_title:Journal of glaucoma

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

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