The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin.

abstract：:The appropriate targeting of membrane-associated proteins involves a diversity of motifs including post-translational modifications and specific protein sequences. Phosphoproteins of the stathmin family are important regulators of microtubule dynamics, in particular in the developing and mature nervous system. Whereas...

journal_title：Journal of cell science

authors： Charbaut E,Chauvin S,Enslen H,Zamaroczy S,Sobel A

更新日期：2005-05-15 00:00:00

abstract：:The study of plasma membrane and phagosome membrane of Dictyostelium discoideum was performed using 2 lectins: concanavalin A (Con A) and Wheat Germ Agglutinin (WGA), and 2 markers of anionic sites: colloidal iron hydroxide (CIH) and cationized ferritin (CF). These labellings were applied to fixed partially broken cel...

journal_title：Journal of cell science

authors： Ryter A,Hellio R

更新日期：1980-02-01 00:00:00

abstract：:Candida albicans is a dimorphic fungus capable of growing as a budding yeast and as a filamentous hypha. We have used the technique of immunofluorescence to study the changes in the microtubule cytoskeleton during the cell cycle in both growth forms. This approach has revealed the presence of an extensive system of mi...

journal_title：Journal of cell science

authors： Barton R,Gull K

更新日期：1988-10-01 00:00:00

abstract：:The contact site A (csA) glycoprotein is a strictly developmentally regulated plasma membrane component responsible for the EDTA-stable (Ca(2+)-independent) form of intercellular adhesion in Dictyostelium discoideum. Using inverse polymerase chain reaction and a terminator vector we have isolated a 1.6 kb genomic frag...

journal_title：Journal of cell science

authors： Faix J,Gerisch G,Noegel AA

更新日期：1992-06-01 00:00:00

abstract：:Proteins destined for the mitochondria travel an intricate pathway through two membranes, each with its own receptors and channels. These proteins interact with receptors via N-terminal presequences that form amphipathic helices. Generally, these helices contain abundant positive charges on one face and hydrophobic re...

journal_title：Journal of cell science

authors： Brydges SD,Carruthers VB

更新日期：2003-11-15 00:00:00

abstract：:Molecular mechanisms of chemotactic response are highly conserved among many eukaryotic cells including human leukocytes and Dictyostelium discoideum cells. The cells can sense the differences in chemoattractant concentration across the cell body and respond by extending pseudopods from the cell side facing to a highe...

journal_title：Journal of cell science

authors： Matsuoka S,Iijima M,Watanabe TM,Kuwayama H,Yanagida T,Devreotes PN,Ueda M

更新日期：2006-03-15 00:00:00

abstract：:Nervous system development and function are tightly regulated by metabolic processes, including the metabolism of lipids such as fatty acids. Mutations in long-chain acyl-CoA synthetase 4 (ACSL4) are associated with non-syndromic intellectual disabilities. We previously reported that Acsl, the Drosophila ortholog of m...

journal_title：Journal of cell science

authors： Huang Y,Huang S,Lam SM,Liu Z,Shui G,Zhang YQ

更新日期：2016-11-01 00:00:00

abstract：:Cell migration involves the dynamic formation and release of cell-substrate adhesions, where the exertion and detection of mechanical forces take place. Members of the calpain family of calcium-dependent proteases are believed to have a central role in these processes, possibly through the regulation of focal adhesion...

journal_title：Journal of cell science

authors： Undyala VV,Dembo M,Cembrola K,Perrin BJ,Huttenlocher A,Elce JS,Greer PA,Wang YL,Beningo KA

更新日期：2008-11-01 00:00:00

abstract：:Mutation of the p53 gene is a common occurrence in human breast cancers but is by no means universal. However, even in tumours where the gene is not mutated altered levels of p53 protein are often detected. This is also observed in cell lines derived from human breast cancers. By transfecting such cell lines containin...

journal_title：Journal of cell science

authors： Vojtĕsek B,Lane DP

更新日期：1993-07-01 00:00:00

abstract：:Neural progenitors in the vertebrate nervous system are fully polarized epithelial cells, with intercellular junctions at the apical region. These progenitor cells remain within the neuroepithelium throughout neurogenesis, and will ultimately give rise to all the neurons in the mature nervous system. We have addressed...

journal_title：Journal of cell science

authors： Afonso C,Henrique D

更新日期：2006-10-15 00:00:00

abstract：:During the interphase to metaphase transition, microtubules are destabilized by a cdc2 kinase-dependent phosphorylation event. This destabilization is due to a dramatic increase in the rate at which each growing microtubule starts to shrink (catastrophe rate). In principle, this could be brought about by lowering the ...

journal_title：Journal of cell science

authors： Faruki S,Dorée M,Karsenti E

更新日期：1992-01-01 00:00:00

abstract：:Microinjected GTP gamma S revealed three distinct steps in the exocytic transport of the temperature sensitive glycoprotein of vesicular stomatitis virus (ts-O45-G) from the ER to the cell surface in intact Vero cells. While COPII dependent export of ts-O45-G from the ER is blocked in cells injected with recombinant p...

journal_title：Journal of cell science

authors： Pepperkok R,Lowe M,Burke B,Kreis TE

更新日期：1998-07-01 00:00:00

abstract：:In the fission yeast Schizosaccharomyces pombe, the protein kinase Chk1 has an essential role in transducing a delay signal to the cell cycle machinery in the presence of DNA damage. Fission yeast cells lacking the chk1 gene do not delay progression of the cell cycle in response to damage and are thus sensitive to DNA...

journal_title：Journal of cell science

authors： Capasso H,Palermo C,Wan S,Rao H,John UP,O'Connell MJ,Walworth NC

更新日期：2002-12-01 00:00:00

abstract：:Notch signaling is a conserved signaling pathway implicated in embryogenesis and adult tissue maintenance. Notch signaling strength is strictly regulated, notably by maintaining a controlled pool of functional receptor at the cell surface. Mammalian non-activated Notch receptor is internalized, ubiquitylated by the It...

journal_title：Journal of cell science

authors： Puca L,Chastagner P,Meas-Yedid V,Israël A,Brou C

更新日期：2013-10-01 00:00:00

abstract：:Pieces of small intestine from newborn, I- and 6-day-old piglets were incubated in vitro and ligated segments were incubated in vivo with polycationic ferritin (PCF) to determine the distribution and possible role in protein uptake of anionic sites on membranes at the luminal surfaces of the epithelial cells. Most PCF...

journal_title：Journal of cell science

authors： Chase CC,Munn EA

更新日期：1980-12-01 00:00:00

abstract：:Oncogenic forms of the non-receptor tyrosine kinase Src alter cell structure, in particular the actin cytoskeleton and the adhesion networks that control cell migration, and also transmit signals that regulate proliferation and cell survival. Recent work indicates that they do so by influencing the RhoA-ROCK pathway t...

journal_title：Journal of cell science

authors： Frame MC

更新日期：2004-03-01 00:00:00

abstract：:The novel protein Nowa was identified in nematocysts, explosive organelles of Hydra, jellyfish, corals and other CNIDARIA: Biogenesis of these organelles is complex and involves assembly of proteins inside a post-Golgi vesicle to form a double-layered capsule with a long tubule. Nowa is the major component of the oute...

journal_title：Journal of cell science

authors： Engel U,Ozbek S,Streitwolf-Engel R,Petri B,Lottspeich F,Holstein TW

更新日期：2002-10-15 00:00:00

abstract：:Desmocollin 3 (Dsc3) is a transmembrane glycoprotein that belongs to the cadherin family of cell adhesion receptors. Together with desmoglein(s), it forms the transmembrane core of desmosomes, a multiprotein complex involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. Previous ...

journal_title：Journal of cell science

authors： Den Z,Cheng X,Merched-Sauvage M,Koch PJ

更新日期：2006-02-01 00:00:00

abstract：:Prion diseases are fatal transmissible neurodegenerative disorders characterized by the accumulation of an abnormally folded isoform of the cellular prion protein (PrP(C)) denoted PrP(Sc). Recently, wild-type and pathogenic PrP mutants have been shown to be degraded by the endoplasmic reticulum-associated degradation ...

journal_title：Journal of cell science

authors： Mangé A,Crozet C,Lehmann S,Béranger F

更新日期：2004-05-01 00:00:00

abstract：:A laser light source along with a new method of preparing endosperm cells of Haemanthus katherinae for differential interference contrast (DIC) microscopy has led to increased visibility of kinetochore fibres. Little information is available concerning the behaviour of these fibres during anaphase in living cells. In ...

journal_title：Journal of cell science

authors： Hard R,Allen RD

更新日期：1977-01-01 00:00:00

abstract：:Asymmetric cell division can produce daughter cells with different developmental fates and is often accompanied by a difference in cell size. A number of recent genetic and in vivo imaging studies in Drosophila and Caenorhabditis elegans have begun to elucidate the mechanisms underlying the rearrangements of the cytos...

journal_title：Journal of cell science

authors： Kaltschmidt JA,Brand AH

更新日期：2002-06-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a transcriptional regulator of genes involved in xenobiotic metabolism. Increasingly clear is also the role of the AhR in the control of cell growth and proliferation. By analyzing differential patterns of gene expression between wild-type (AhR+/+) and null (AhR-/-) mouse embryo ...

journal_title：Journal of cell science

authors： Santiago-Josefat B,Mulero-Navarro S,Dallas SL,Fernandez-Salguero PM

更新日期：2004-02-29 00:00:00

abstract：:Axin and conductin (also known as axin2) are structurally related inhibitors of Wnt/β-catenin signalling that promote degradation of β-catenin. Whereas axin is constitutively expressed, conductin is a Wnt target gene implicated in Wnt negative-feedback regulation. Here, we show that axin and conductin differ in their ...

journal_title：Journal of cell science

authors： Bernkopf DB,Hadjihannas MV,Behrens J

更新日期：2015-01-01 00:00:00

abstract：:The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) defines a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF). Here, we describe a LEM protein annotated in databases as 'Ankyrin r...

journal_title：Journal of cell science

authors： Brachner A,Braun J,Ghodgaonkar M,Castor D,Zlopasa L,Ehrlich V,Jiricny J,Gotzmann J,Knasmüller S,Foisner R

更新日期：2012-02-15 00:00:00

abstract：:The conformation and biological activities of fibronectin (FN) and vitronectin (VN) coated on different plastic surfaces were investigated using cell adhesion and a panel of domain-specific monoclonal antibodies (mAbs). The adhesion of BHK fibroblasts was markedly better on FN coated on hydrophilic tissue culture poly...

journal_title：Journal of cell science

authors： Underwood PA,Steele JG,Dalton BA

更新日期：1993-03-01 00:00:00

abstract：:We have shown previously, by fluorescent antibody staining, that desmosomal antigens are widely distributed in the tissues of vertebrate animals. Furthermore, we have demonstrated mutual desmosome formation between cells derived from man, cow, dog, chicken and frog. In this paper we have studied the components of desm...

journal_title：Journal of cell science

authors： Suhrbier A,Garrod D

更新日期：1986-03-01 00:00:00

abstract：:Integrin alpha1beta1 is a collagen receptor predominantly found in mesenchymal tissues. Mice lacking this receptor are viable. We have previously suggested that alpha1beta1 might participate in the down-regulation of collagen gene expression observed in cells suspended inside collagen gels. The results presented here ...

journal_title：Journal of cell science

authors： Gardner H,Broberg A,Pozzi A,Laato M,Heino J

更新日期：1999-02-01 00:00:00

abstract：:The formation of cytoplasmic stress granules and the innate immune response are two distinct cellular stress responses. Our study investigated the involvement of four innate immune proteins - retinoic-acid-inducible gene I (RIG-I, also known as DDX58), melanoma differentiation-associated gene 5 (MDA5, also known as IF...

journal_title：Journal of cell science

authors： Zhang P,Li Y,Xia J,He J,Pu J,Xie J,Wu S,Feng L,Huang X,Zhang P

更新日期：2014-06-01 00:00:00

abstract：:A transformed variant derived as a clone from normal 3T3 cells infected with simian virus 40 (SV40) has been found to possess a phenotype intermediate between that of normal cells and that characteristic of the transformed state, yet cells of the variant still test positively for the SV40-specific nuclear T-antigen. T...

journal_title：Journal of cell science

authors： Thompson JE,Elligsen JD,Frey HE

更新日期：1975-08-01 00:00:00

abstract：:Postsynaptic neuronal dendrites undergo functional and morphological changes in response to pathologically excessive synaptic activation. Although rapid formation of segmental focal swelling (varicosity) is the most prominent hallmark in such excitotoxic injury, little is known about the pathophysiological function of...

journal_title：Journal of cell science

authors： Ikegaya Y,Kim JA,Baba M,Iwatsubo T,Nishiyama N,Matsuki N

更新日期：2001-11-01 00:00:00