Oligodendrocytes: from development to demyelinated lesion repair.

Abstract:

:Spontaneous but incomplete remyelination is observed after a demyelinating lesion. We know since ten years now that oligodendrocyte progenitors, (OP) and totipotent neural stem cells remain present in the central nervous system of adult mammals. Moreover, these OP are more likely the cellular source of remyelinating cells. Here, we intend to demonstrate that the understanding of the myelination process that occurs during development might lead to new treatments aimed at inducing remyelination: stimulation of resident OP or grafting of purified perinatal OP.

journal_name

Acta Neurol Belg

journal_title

Acta neurologica Belgica

authors

Rogister B,Belachew S,Moonen G

keywords:

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

32-9

issue

1

eissn

0300-9009

issn

2240-2993

journal_volume

99

pub_type

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