A case study of selected medical findings among plutonium injectees.

Abstract:

:Available medical records of plutonium injectees exposed in experimental studies of plutonium biokinetics under Manhattan Engineer District auspices have been reviewed for subsequent medical findings potentially related to the plutonium exposures. Five subjects who had been injected with approximately 11 kBq 239Pu, and one injected with 3.5 kBq 238Pu, had useful follow-up medical data. Bone lesions dominated the findings: none of six subjects with follow-up for bone conditions lacked bone lesions clearly or potentially caused, or worsened, by plutonium. Roentgenograms of three subjects, read by a radiologist experienced reading films of radium cases, demonstrated possible to likely plutonium effects. Two cases of osteoporosis or non-specific degenerative changes were seen, associated with a hip fracture and vertebral fractures. Areas of increased bone density were seen, as well as numerous dystopic calcifications and one unusual case of widespread pathologic calcification on bone surfaces probably due to a plutonium-related calciphylactic reaction. Non-skeletal findings include labyrinthitis with inflammatory mastoid changes, conduction deafness, and a benign neurofibroma directly adjacent to bone. The radium literature contains similar observed findings, but interpretation of these limited clinical observations is hampered by lack of quantitative data on humans exposed to radium with respect to prevalence of non-specific ear, mastoid, and skeletal symptomatologies or x-ray findings, or cumulative incidence rates of bone fractures or of other physical disabilities related to ear, mastoid, or bone damage. Disability and invalidism late in life can be risk factors for earlier mortality.

journal_name

Health Phys

journal_title

Health physics

authors

Stebbings JH

doi

10.1097/00004032-199905000-00003

keywords:

subject

Has Abstract

pub_date

1999-05-01 00:00:00

pages

477-88

issue

5

eissn

0017-9078

issn

1538-5159

journal_volume

76

pub_type

杂志文章
  • Radioactive contamination of the Adriatic Sea by 90Sr and 137Cs.

    abstract::Results of systematic long-term measurements of 90Sr and 137Cs in surface seawater, performed at four locations along the Croatian coast of the Adriatic Sea, are summarized. Observed trends in annual mean activity concentrations are discussed. 90Sr and 137Cs fallout activities affect seawater activity, the coefficient...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199302000-00006

    authors: Franić Z,Bauman A

    更新日期:1993-02-01 00:00:00

  • An experimental and mathematical analysis of lymphopoiesis dynamics under continuous irradiation.

    abstract::A mathematical model describing the dynamics of lymphopoiesis in mammals continuously exposed to ionizing radiation has been developed. It is based on the theory of chalone regulation of hematopoiesis. The model comprises a system of nine differential equations. Results from the model were compared with our experiment...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199107000-00009

    authors: Zukhbaya TM,Smirnova OA

    更新日期:1991-07-01 00:00:00

  • Design of a positionally sensitive laser-heated thermoluminescent detector system.

    abstract::The design and performance of a positionally sensitive system for the laser read-out of dosimetric information contained in LiF chips and a specially designed composite detector having a thin LiF layer is reported. A 2 cm X 3 cm X 0.254 mm LiF layer was successfully manufactured with a glass backing; however, this was...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199010000-00004

    authors: Kearfott KJ,Grupen-Shemansky ME

    更新日期:1990-10-01 00:00:00

  • A contribution to optimizing radiological protection in a U mine.

    abstract::This article presents an optimization study for radiological protection in a U mine. The mathematical model of the alpha contamination associated with short-lived Rn daughters allows the comparison of various protection strategies through a cost-effectiveness analysis. Determining the optimal protection strategy is ca...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198604000-00004

    authors: Lombard J,Oudiz A,Zettwoog P

    更新日期:1986-04-01 00:00:00

  • The 15th Annual Warren K. Sinclair Keynote Address-Jus•ti•fied and Com•men•su•rate.

    abstract::When patients are exposed to ionizing radiation for medical diagnosis or treatment, the procedure being performed should be justified, and the amount of ionizing radiation used should be commensurate with the medical purpose. A legal limit on the amount of ionizing radiation used for medical exposure of a patient does...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000988

    authors: Rosenstein M

    更新日期:2019-02-01 00:00:00

  • Analysis of uranium in drinking water samples using laser induced fluorimetry.

    abstract::Uranium concentration in drinking water samples collected from some areas of Punjab and Himachal Pradesh has been measured using a laser induced fluorimetry technique. The sources of water comprise hand pumps and tube wells. Uranium concentration in the water samples from Punjab varies from 1.39 +/- 0.16 to 98.25 +/- ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000202233.64500.89

    authors: Rani A,Singh S

    更新日期:2006-08-01 00:00:00

  • Lessons learned in preparing to receive large numbers of contaminated individuals.

    abstract::Traditionally, medical radiation emergency plans have provided for the receipt and care of a limited number of individuals, usually no more than two or three at any given time. Large numbers of contaminated, uninjured individuals cannot be effectively handled in the emergency departments (EDs) of hospitals as they pre...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.hp.0000165870.08277.b8

    authors: Miller K,Groff L,Erdman M,King S

    更新日期:2005-08-01 00:00:00

  • Radiation exposure of German aircraft crews under the impact of solar cycle 23 and airline business factors.

    abstract::The exposure of German aircraft crews to cosmic radiation varies both with solar activity and operational factors of airline business. Data come from the German central dose registry and cover monthly exposures of up to 37,000 German aircraft crewmembers that were under official monitoring. During the years 2004 to 20...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000150

    authors: Frasch G,Kammerer L,Karofsky R,Schlosser A,Stegemann R

    更新日期:2014-12-01 00:00:00

  • Assessment of self-help methods to reduce potential exposure to radiological contamination after a large-scale radiological release.

    abstract::After the release of radioactive materials from a large radiological dispersal device (e.g., dirty bomb), improvised nuclear detonation, or nuclear power plant accident, up to hundreds of square miles may be contaminated. A portion of this area will be evacuated; however, people living in the portion that is not evacu...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000101

    authors: Snyder E,Drake J,Cardarelli J,Hall K,Szabo J,Demmer R,Lindberg M,Riggs K,James R

    更新日期:2014-09-01 00:00:00

  • Estimation of absorbed dose in cell nuclei due to DNA-bound 3H.

    abstract::The average absorbed dose due to DNA-bound 3H in a cell nucleus was estimated by a Monte Carlo simulation for a model nucleus which was assumed to be spheroidal. The shape of the cell nucleus was found to be of minor importance in determining the average absorbed dose. The volume of the cell nucleus was the major dose...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198504000-00009

    authors: Saito M,Ishida MR,Streffer C,Molls M

    更新日期:1985-04-01 00:00:00

  • Sorption of 99mTc radiopharmaceutical compounds by soils.

    abstract::Study of the sorption of 99mTc radiopharmaceutical compounds by soils has assessed the fate of these compounds in the event of a surface spill and examined the potential of these compounds as hydrologic tracers. Sorption from deionized water, filtered Missouri River water, and artificial seawater by five surface soils...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.hp.0000128583.33124.7d

    authors: Jurisson S,Gawenis J,Landa ER

    更新日期:2004-10-01 00:00:00

  • Deterministic Effects to the Lens of the Eye Following Ionizing Radiation Exposure: is There Evidence to Support a Reduction in Threshold Dose?

    abstract::Ionizing radiation exposure to the lens of the eye is a known cause of cataractogenesis. Historically, it was believed that the acute threshold dose for cataract formation was 5 Sv, and annual dose limits to the lens were set at 150 mSv. Recently, however, the International Commission on Radiological Protection has re...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000810

    authors: Thome C,Chambers DB,Hooker AM,Thompson JW,Boreham DR

    更新日期:2018-03-01 00:00:00

  • In vitro dissolution of respirable aerosols of industrial uranium and plutonium mixed-oxide nuclear fuels.

    abstract::Dissolution characteristics of mixed-oxide nuclear fuels are important considerations for prediction of biological behavior of inhaled particles. Four representative industrial mixed-oxide powders were obtained from fuel fabrication enclosures. Studies of the dissolution of Pu, Am and U from aerosol particles of these...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198312000-00001

    authors: Eidson AF,Mewhinney JA

    更新日期:1983-12-01 00:00:00

  • Results of a survey on the implementation of diagnostic reference levels for X-rays among Dutch hospitals.

    abstract::Diagnostic reference levels (DRLs) for medical x-ray procedures are being implemented currently in the Netherlands. By order of the Dutch Healthcare Inspectorate, a survey has been conducted among 20 Dutch hospitals to investigate the level of implementation of the Dutch DRLs in current radiological practice. It turns...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000227

    authors: Bijwaard H,Valk D,de Waard-Schalkx I

    更新日期:2015-04-01 00:00:00

  • Utilizing K-12 school and higher education programs to incorporate homeland security topics for public education.

    abstract::The broad based mission statements of public institutions whose charters are to educate the public is analyzed so that common threads pertinent to homeland security action items can be correlated with the public education scope. The intent of the coordination is to ensure that the prevention component in addition to t...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200308001-00013

    authors: McCarthy ME

    更新日期:2003-08-01 00:00:00

  • Evaluation of scattered radiation in a calibration range using exposure rate energy spectra.

    abstract::ISO standard 4037 specifies that for calibrating protection level dosimeters, scattered radiation should contribute less than 5% of the exposure. In previous work, the authors reported the results of an MCNP analysis of the shadow shield technique that was performed for a calibration range with a Cs irradiator. This p...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3182259a98

    authors: Petrie CM,Blue TE,Herminghuysen K

    更新日期:2012-01-01 00:00:00

  • Actinides concentrations in human tissues.

    abstract::Fallout 239,240Pu concentrations in some autopsy tissues from the general population in Japan are described. Body burden and relative distribution among tissues of plutonium were obtained by extrapolating using the mass of relevant tissues of the normal Japanese adult. 239,240Pu-to-90Sr body burden ratio was obtained....

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198306001-00043

    authors: Kawamura H,Tanaka G

    更新日期:1983-01-01 00:00:00

  • Measuring Workload with Paired Detectors.

    abstract::Linear accelerator workloads for each available photon energy are important quantities to know for radiation safety considerations, and presented is a technique to measure the workload using paired detectors. The signals from the two detectors can give sufficient information to separate the signal contributions from 6...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000984

    authors: Corns R,Schroeder C,Sandhu G,Henderson K,McKay I

    更新日期:2019-09-01 00:00:00

  • Inhalation and intravenous studies of UF6/UO2F2 in dogs.

    abstract::Nineteen UF6/UO2F2 inhalation studies were undertaken in purebred, female beagle dogs (N = 16) to examine inter alia, (a) the possible relations of exposure, whole body, lung and renal uranium levels to excretion rates; (b) the threshold U6+ dose and renal concentration for renal injury; (c) the distribution and reten...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198212000-00008

    authors: Morrow P,Gelein R,Beiter H,Scott J,Picano J,Yuile C

    更新日期:1982-12-01 00:00:00

  • The acute gastrointestinal subsyndrome of the acute radiation syndrome: a rhesus macaque model.

    abstract::The development of medical countermeasures against the acute gastrointestinal subsyndrome of the acute radiation syndrome in humans requires well characterized and validated animal models. These models must adhere to the criteria of the U.S. Food and Drug Administration's Animal Rule and consider the natural history a...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e31826525f0

    authors: MacVittie TJ,Farese AM,Bennett A,Gelfond D,Shea-Donohue T,Tudor G,Booth C,McFarland E,Jackson W 3rd

    更新日期:2012-10-01 00:00:00

  • The Effects of Radiation and Emitted Light Transport on the Positional Response of 11 cm × 42.5 cm × 5.5 cm NaI(Tl) Detectors.

    abstract::Experiments were performed with 30 11 cm × 42.5 cm × 5.5 cm NaI(Tl) detectors to better understand their positional response. Spectra were collected using 0.02 to 0.15 MBq point sources of Am, Cs, Co, and Ba positioned on lines parallel and perpendicular to the long axis of the crystal along both the narrow and wide d...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001051

    authors: Noey JD,Xiao JB,DiFulvio A,Sulieman NA,Carmona MA,Chung LK,El-Amir IN,Frank SJ,Liu K,Schiefer K,Seekamp JM,Sosa CS,Trimas DJ,Vyas AP,Kearfott KJ

    更新日期:2019-10-01 00:00:00

  • A constant flow filter air sampler for workplace environments.

    abstract::A filter air sampler has been developed for sampling radionuclide aerosol particles from the workplace environment. It provides easy filter changing, constant flow sampling, and a visual display to indicate proper operation. An experimental study was conducted to characterize the collection efficiency of the sampler a...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199612000-00003

    authors: Parulian A,Rodgers JC,McFarland AR

    更新日期:1996-12-01 00:00:00

  • Adapting MARSSIM for FUSRAP site closure.

    abstract::The Multi-Agency Radiation Survey and Site Investigation Manual (MARSSIM) provides a coherent, technically defensible process for establishing that exposed surfaces satisfy site cleanup requirements. Unfortunately, many sites have complications that challenge a direct application of MARSSIM. Example complications incl...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200306003-00005

    authors: Johnson R,Durham L,Rieman C

    更新日期:2003-06-01 00:00:00

  • Ultraviolet response of CaF2:Tm with high-temperature treatment.

    abstract::The thermoluminescent (TL) response to ultraviolet irradiation of CaF2:Tm phosphor is affected by pre-irradiation high-temperature treatment. The experimental results indicate that the maximum intrinsic TL output is about 2000 times higher for 1000 degrees C treatment than when not treated. TL stability for this phosp...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199112000-00017

    authors: Li SH,Hsu PC,Weng PS

    更新日期:1991-12-01 00:00:00

  • Deterministic effects of 241Am exposure in the Hanford Americium accident case.

    abstract::Lifetime follow-up of USTUR Case 246 demonstrated the lack of severe biological effects resulting from his exposure to 241Am. Deterministic effects observed were limited to hematological changes, including lymphopenia and thrombocytopenia. These hematological changes were consistent with those observed in experimental...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199509000-00005

    authors: Filipy RE,Toohey RE,Kathren RL,Dietert SE

    更新日期:1995-09-01 00:00:00

  • Measurement of airborne 218Po--a Bayesian approach.

    abstract::The standard mathematical treatment of the buildup and decay of airborne radionuclides on a filter paper uses the solutions of the so-called Bateman equations adapted to the sampling process. These equations can be interpreted as differential equations for the expectation of an underlying stochastic process, which des...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199612000-00013

    authors: Groer PG,Lo Y

    更新日期:1996-12-01 00:00:00

  • Radiation protection--a look to the future: ICRP perceptions.

    abstract::The author was invited to talk about ICRP perceptions of a look to the future. Many questions will be addressed when the International Commission on Radiological Protection (ICRP) initiates a revision of its basic recommendations from 1977, which were published in ICRP Publication 26. This process will take several ye...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198808000-00004

    authors: Lindell B

    更新日期:1988-08-01 00:00:00

  • Calculation of absorbed energy in the gastrointestinal tract.

    abstract::One goal of this research was to reproduce the photon specific absorbed fraction calculations of Cristy and Eckerman using their gastrointestinal (GI) tract model. A second goal was to calculate photon specific absorbed fraction values for their GI tract model using electron tracking techniques. A final goal was to ca...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199609000-00005

    authors: Poston JW Jr,Kodimer KA,Bolch WE,Poston JW Sr

    更新日期:1996-09-01 00:00:00

  • Radiofrequency exposure from wireless LANs utilizing Wi-Fi technology.

    abstract::This survey measured radiofrequency (RF) fields from wireless local area networks (WLANs) using Wi-Fi technology against a background of RF fields in the environment over the frequency range 75 MHz-3 GHz. A total of 356 measurements were conducted at 55 sites (including private residences, commercial spaces, health ca...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000248117.74843.34

    authors: Foster KR

    更新日期:2007-03-01 00:00:00

  • Operational radiation safety for PET-CT, SPECT-CT, and cyclotron facilities.

    abstract::Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are well- established and indispensable imaging modalities in modern medicine. State-of-the-art computed tomography (CT) scanners have now been integrated into multi-modality PET-CT and SPECT-CT devices, and these devices, partic...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000327651.15794.f7

    authors: Zanzonico P,Dauer L,St Germain J

    更新日期:2008-11-01 00:00:00