A Prognostic Model Based on Immune-Related Long Non-Coding RNAs for Patients With Cervical Cancer.

abstract：:The recent publication of the σ1R crystal structure is an important cornerstone for the derivation of more accurate activity prediction models. We report here a comparative study involving a set of more than 25,000 structures from our internal database that had been screened for σ1R affinity. Using the recently publis...

journal_title：Frontiers in pharmacology

authors： Pascual R,Almansa C,Plata-Salamán C,Vela JM

更新日期：2019-05-31 00:00:00

abstract：:2,5-Dimethoxy-4-ethylphenethylamine (2C-E) is psychedelic phenylethylamine, with a chemical structure similar to mescaline, used as new psychoactive substance (NPS). It inhibits norepinephrine and serotonin uptake and, more relevant, acts as a partial agonist of the serotonin 2A (5-HT2A), 2B (5-HT2B), and (5-HT2C) rec...

journal_title：Frontiers in pharmacology

authors： Papaseit E,Olesti E,Pérez-Mañá C,Torrens M,Grifell M,Ventura M,Pozo OJ,de Sousa Fernandes Perna EB,Ramaekers JG,de la Torre R,Farré M

更新日期：2020-03-18 00:00:00

abstract：:Depression is a widespread chronic medical illness affecting thoughts, mood, and physical health. However, the limited and delayed therapeutic efficacy of monoaminergic drugs has led to intensive research efforts to develop novel antidepressants. ARN-3236 is the first potent and selective inhibitor of salt-inducible k...

journal_title：Frontiers in pharmacology

authors： Liu Y,Tang W,Ji C,Gu J,Chen Y,Huang J,Zhao X,Sun Y,Wang C,Guan W,Liu J,Jiang B

更新日期：2021-01-14 00:00:00

abstract：:The potential of multifunctional wound heal biomaterial relies on the optimal content of therapeutic constituents as well as the desirable physical, chemical, and biological properties to accelerate the healing process. Formulating biomaterials such as amnion or collagen based scaffolds with natural products offer an ...

journal_title：Frontiers in pharmacology

authors： Sivasubramanian S,Chandrasekar G,Svensson Akusjärvi S,Thangam R,Sathuvan M,Kumar RBS,Hussein H,Vincent S,Madhan B,Gunasekaran P,Kitambi SS

更新日期：2017-07-18 00:00:00

abstract：:Successful drug delivery using implantable pumps may be found in over 12,500 published articles. Their versatility in delivering continuous infusion, intermittent or complex infusion protocols acutely or chronically has made them ubiquitous in drug discovery and basic research. The recent availability of iPRECIO(®), a...

journal_title：Frontiers in pharmacology

authors： Tan T,Watts SW,Davis RP

更新日期：2011-07-29 00:00:00

abstract：:Flavonoids are some of the most important natural products with a variety of physiological activities. 8-Formylophiopogonanone B (8-FOB) is a naturally existing homoisoflavonoid in Ophiopogon japonicus. Paraquat (PQ) has been widely used as a potent herbicide and has high toxicity in humans. The goal of the present st...

journal_title：Frontiers in pharmacology

authors： Qian JY,Deng P,Liang YD,Pang L,Wu LC,Yang LL,Zhou Z,Yu ZP

更新日期：2019-10-24 00:00:00

abstract：:Hepatosteatosis (HS), a clinical feature of fatty liver with the excessive intracellular accumulation of triglyceride in hepatocytes, is manifested by perturbation of the maintenance of liver lipid homeostasis. Samjunghwan (SJH) is an herbal formula used mostly in Korean traditional medicine that is effective against ...

journal_title：Frontiers in pharmacology

authors： Ansari A,Bose S,Patra JK,Shin NR,Lim DW,Kim KW,Wang JH,Kim YM,Chin YW,Kim H

更新日期：2018-06-19 00:00:00

abstract：:Cardiac remodeling, which is characterized by mechanical and electrical remodeling, is a significant pathophysiological process involved in almost all forms of heart diseases. MicroRNAs (miRNAs) are a group of non-coding RNAs of 20-25 nucleotides in length that primarily regulate gene expression by promoting mRNA degr...

journal_title：Frontiers in pharmacology

authors： Li N,Zhou H,Tang Q

更新日期：2018-08-17 00:00:00

abstract：:With multiple omics strategies being applied to several cancer genomics projects, researchers have the opportunity to develop a rational planning of targeted cancer therapy. The investigation of such numerous and diverse pharmacogenomic datasets is a complex task. It requires biological knowledge and skills on a set o...

journal_title：Frontiers in pharmacology

authors： Belizário JE,Sangiuliano BA,Perez-Sosa M,Neyra JM,Moreira DF

更新日期：2016-09-29 00:00:00

abstract：:Skeletal dysplasias represent a large and diverse group of rare conditions affecting collagen and bone. They can be clinically classified based on radiographic and physical features, and many can be further defined at a molecular level (Bonafe et al., 2015). Early diagnosis is critical to proper medical management inc...

journal_title：Frontiers in pharmacology

authors： Jelin AC,O'Hare E,Blakemore K,Jelin EB,Valle D,Hoover-Fong J

更新日期：2017-03-06 00:00:00

abstract：PURPOSE:Colostrum has been proposed to treat severe dryness and problematic eye lesions showing a beneficial effect. The aim of the study was to investigate the effect of 2-fucosyl-lactose, a natural sugar present in the human colostrum, in an experimental dry eye. METHODS:Dry eye was induced in adult male New Zealand...

journal_title：Frontiers in pharmacology

authors： Bucolo C,Musumeci M,Salomone S,Romano GL,Leggio GM,Gagliano C,Reibaldi M,Avitabile T,Uva MG,Musumeci S,Drago F

更新日期：2015-11-18 00:00:00

abstract：:A large and growing body of literature has focused on the association between "white coat hypertension" (WCH) and the underlying target organ damage. The evidence suggests that WCH is may not an entirely benign phenomenon. However, whether patients with WCH should receive antihypertensive drugs is unresolved. Therefor...

journal_title：Frontiers in pharmacology

authors： Xiang H,Xue Y,Wang J,Weng Y,Rong F,Peng Y,Ji K

更新日期：2020-09-17 00:00:00

abstract：:Tolvaptan (TLV), an oral non-peptide antagonist of vasopressin V2 receptor, has been increasingly used for managements in patients with hyponatremia and/or syndrome of inappropriate antidiuretic hormone secretion. However, none of the studies have thus far been investigated with regard to its possible perturbations on...

journal_title：Frontiers in pharmacology

authors： Lu TL,Chang WT,Chan CH,Wu SN

更新日期：2019-02-18 00:00:00

abstract：:MaZiRenWan (MZRW, also known as Hemp Seed Pill) is a Chinese Herbal Medicine which has been demonstrated to safely and effectively alleviate functional constipation (FC) in a randomized, placebo-controlled clinical study with 120 subjects. However, the underlying pharmacological actions of MZRW for FC, are still large...

journal_title：Frontiers in pharmacology

authors： Huang T,Ning Z,Hu D,Zhang M,Zhao L,Lin C,Zhong LLD,Yang Z,Xu H,Bian Z

更新日期：2018-03-26 00:00:00

abstract：:The Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2) or novel coronavirus (COVID-19) infection has been declared world pandemic causing a worrisome number of deaths, especially among vulnerable citizens, in 209 countries around the world. Although several therapeutic molecules are being tested, no ...

journal_title：Frontiers in pharmacology

authors： Benarba B,Pandiella A

更新日期：2020-08-07 00:00:00

abstract：:Traditional Chinese medicine is one of the complementary and alternative therapies to improve the prognosis of coronary heart disease (CHD). Taohong Siwu Decoction (THSWD), a classical traditional Chinese medication that promotes blood circulation, is clinically beneficial in CHD. However, the underlying mechanism of ...

journal_title：Frontiers in pharmacology

authors： Tao T,He T,Mao H,Wu X,Liu X

更新日期：2020-05-08 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphar.2020.00739.]. ...

journal_title：Frontiers in pharmacology

authors： Huang J,Hei GR,Yang Y,Liu CC,Xiao JM,Long YJ,Peng XJ,Yang Y,Zhao JP,Wu RR

更新日期：2020-06-10 00:00:00

abstract：:This study explores historical iatrosophia texts from Cyprus from a botanical and medico-pharmacological point of view focusing on remedies containing resins and gums. The iatrosophia are a genre of Greek medical literature of Byzantine origin and can be described as medicine handbooks which serve as therapeutic repos...

journal_title：Frontiers in pharmacology

authors： Lardos A,Prieto-Garcia J,Heinrich M

更新日期：2011-07-01 00:00:00

abstract：:Epigenetics refers to heritable changes in gene expression and chromatin structure without change in a DNA sequence. Several epigenetic modifications and respective regulators have been reported. These include DNA methylation, chromatin remodeling, histone post-translational modifications, and non-coding RNAs. Emergin...

journal_title：Frontiers in pharmacology

authors： Akone SH,Ntie-Kang F,Stuhldreier F,Ewonkem MB,Noah AM,Mouelle SEM,Müller R

更新日期：2020-08-13 00:00:00

abstract：:In-depth research on processing can promote the globalization of processed herbs. The purpose of this study is to propose an improved strategy for processing effect investigation. Frankincense and processed frankincense were used as research subjects. First, high-speed countercurrent chromatography (HSCCC) and prepara...

journal_title：Frontiers in pharmacology

authors： Ning Z,Wang C,Liu Y,Song Z,Ma X,Liang D,Liu Z,Lu A

更新日期：2018-12-18 00:00:00

abstract：:Background: Rheumatoid arthritis is a type of systemic and complex autoimmune other disease characterized by chronic joint inflammation. Spleen tyrosine kinase (Syk) inhibitors are regarded as an effective alternative to existing drugs for the treatment of this disease. However, studies evaluating fostamatinib, a new ...

journal_title：Frontiers in pharmacology

authors： Kang Y,Jiang X,Qin D,Wang L,Yang J,Wu A,Huang F,Ye Y,Wu J

更新日期：2019-08-14 00:00:00

abstract：:Rodent models of human disease can be valuable for understanding the mechanisms of a disease and for identifying novel therapies. However, it is critical that these models be vetted prior to committing resources to developing novel therapeutics. Failure to confirm the model can lead to significant losses in time and r...

journal_title：Frontiers in pharmacology

authors： Caudle RM,Caudle SL,Flenor ND,Rohrs EL,Neubert JK

更新日期：2020-12-03 00:00:00

abstract：:The skin is the main barrier that protects us against environmental stressors (physical, chemical, and biological). These stressors, combined with internal factors, are responsible for cutaneous aging. Furthermore, they negatively affect the skin and increase the risk of cutaneous diseases, particularly skin cancer. T...

journal_title：Frontiers in pharmacology

authors： Parrado C,Mercado-Saenz S,Perez-Davo A,Gilaberte Y,Gonzalez S,Juarranz A

更新日期：2019-07-09 00:00:00

abstract：:High levels of emotional arousal can impair spatial memory mediated by the hippocampus, and enhance stimulus-response (S-R) habit memory mediated by the dorsolateral striatum (DLS). The present study was conducted to determine whether these memory systems may be similarly affected in an animal model of post-traumatic ...

journal_title：Frontiers in pharmacology

authors： Goodman J,McIntyre CK

更新日期：2017-09-22 00:00:00

abstract：:Postoperative ileus (POI) and postoperative gastrointestinal tract dysfunction (POGD) are well-known complications affecting patients undergoing intestinal surgery. GI symptoms include nausea, vomiting, pain, abdominal distention, bloating, and constipation. These iatrogenic disorders are associated with extended hosp...

journal_title：Frontiers in pharmacology

authors： Mazzotta E,Villalobos-Hernandez EC,Fiorda-Diaz J,Harzman A,Christofi FL

更新日期：2020-11-24 00:00:00

abstract：:The number of colorectal cancer (CRC) cases have increased gradually year by year. In fact, CRC is one of the most widely diagnosed cancer in men and women today. This disease is usually diagnosed at a later stage of the development, and by then, the chance of survival has declined significantly. Even though substanti...

journal_title：Frontiers in pharmacology

authors： Hon KW,Abu N,Ab Mutalib NS,Jamal R

更新日期：2017-08-28 00:00:00

abstract：:Free radicals act as secondary messengers, modulating a number of important biological processes, including gene expression, ion mobilization in transport systems, protein interactions and enzymatic functions, cell growth, cell cycle, redox homeostasis, among others. In the cardiovascular system, the physiological gen...

journal_title：Frontiers in pharmacology

authors： da Costa RM,Rodrigues D,Pereira CA,Silva JF,Alves JV,Lobato NS,Tostes RC

更新日期：2019-04-12 00:00:00

abstract：:Pharmaceutical medicine has evolved to be a distinct medical scientific discipline over time. Pharmaceutical medicine has distinctive features related to complex innovative medicines development activities in an often commercially focused competitive environment. This sometimes uneasy mix of professionalism and commer...

journal_title：Frontiers in pharmacology

authors： Morris T,Brostoff JM,Stonier PD,Boyd A

更新日期：2020-01-15 00:00:00

abstract：:Background: Yixinshu Capsules (YXSC) are widely used in Chinese medicine for the treatment of cardiovascular diseases. However, the therapeutic mechanisms of action are not well understood. Method: In this study, a metabonomic approach based on integrated UPLC-Q/TOF-MS technique and MALDI-MS was utilized to explore po...

journal_title：Frontiers in pharmacology

authors： Xu J,Li X,Zhang F,Tang L,Wei J,Lei X,Wang H,Zhang Y,Li D,Tang X,Li G,Tang S,Wu H,Yang H

更新日期：2019-12-06 00:00:00

abstract：:Cancer is a common malignant disease worldwide with an increasing mortality in recent years. Salvia miltiorrhiza, a well-known traditional Chinese medicine, has been used for the treatment of cardiovascular and cerebrovascular diseases for thousands of years. The liposoluble tanshinones in S. miltiorrhiza are importan...

journal_title：Frontiers in pharmacology

authors： Fu L,Han B,Zhou Y,Ren J,Cao W,Patel G,Kai G,Zhang J

更新日期：2020-03-19 00:00:00