Abstract:
:The aim of this study was to evaluate patient perception of surgical discomfort in third molar surgery and the association with clinical variables and polymorphisms associated with the FKBP5, SLC6A4, and COMT genes. This cross-sectional observational study was carried out on 196 participants aged between 18 and 64 years at the Federal University of Paraná in 11 months. The intensity of surgical discomfort was assessed using the QCirDental questionnaire. Data on surgical and individual procedures were also cataloged. The oral health related quality of life was assessed by the Oral Health Impact Profile questionnaire (OHIP-14). The DNA sample was obtained from cells of the oral mucosa. Five markers of the FKBP5, SLC6A4, and COMT genes were genotyped. The data were submitted to statistical analysis with a significance level of 5%. Women reported greater intensity of discomfort associated with third molar surgery compared to men (p = 0.001). In the recessive model, the AA genotype of the rs3800373 marker was associated with greater surgical discomfort (p = 0.026). Therefore, women and individuals of the AA genotype for the rs3800373 marker in the FKBP5 gene reported greater surgical discomfort associated with third molar surgery.
journal_name
Braz Oral Resjournal_title
Brazilian oral researchauthors
Reis GEDS,Calixto RD,Petinati MFP,Souza JF,Kuchler EC,Costa DJD,Bonotto D,Rebellato NLB,Scariot Rdoi
10.1590/1807-3107bor-2021.vol35.0007subject
Has Abstractpub_date
2020-11-13 00:00:00pages
e007eissn
1806-8324issn
1807-3107pii
S1806-83242021000100206journal_volume
35pub_type
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