Effect of different factors on patient perception of surgical discomfort in third molar surgery.

Abstract:

:The aim of this study was to evaluate patient perception of surgical discomfort in third molar surgery and the association with clinical variables and polymorphisms associated with the FKBP5, SLC6A4, and COMT genes. This cross-sectional observational study was carried out on 196 participants aged between 18 and 64 years at the Federal University of Paraná in 11 months. The intensity of surgical discomfort was assessed using the QCirDental questionnaire. Data on surgical and individual procedures were also cataloged. The oral health related quality of life was assessed by the Oral Health Impact Profile questionnaire (OHIP-14). The DNA sample was obtained from cells of the oral mucosa. Five markers of the FKBP5, SLC6A4, and COMT genes were genotyped. The data were submitted to statistical analysis with a significance level of 5%. Women reported greater intensity of discomfort associated with third molar surgery compared to men (p = 0.001). In the recessive model, the AA genotype of the rs3800373 marker was associated with greater surgical discomfort (p = 0.026). Therefore, women and individuals of the AA genotype for the rs3800373 marker in the FKBP5 gene reported greater surgical discomfort associated with third molar surgery.

journal_name

Braz Oral Res

journal_title

Brazilian oral research

authors

Reis GEDS,Calixto RD,Petinati MFP,Souza JF,Kuchler EC,Costa DJD,Bonotto D,Rebellato NLB,Scariot R

doi

10.1590/1807-3107bor-2021.vol35.0007

subject

Has Abstract

pub_date

2020-11-13 00:00:00

pages

e007

eissn

1806-8324

issn

1807-3107

pii

S1806-83242021000100206

journal_volume

35

pub_type

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