Abstract：
:The aim of this study was to evaluate the demographic, clinical, and therapeutic characteristics and predictive factors of poor prognosis in patients with primary oral squamous cell carcinoma (OSCC) in Uruguay. Medical records of patients with the diagnosis of primary OSCC treated between 2000 and 2010 in Uruguayan public hospitals were selected. Data on demographic characteristics, risk factors, clinical features, treatment, and outcome were collected. Associations of independent variables with outcomes were assessed using Pearson chi-squared and Fisher's tests. Of 200 patients with OSCC, 79.4% were men (3.8:1 male:female ratio), with a mean age of 60.75 ± 11.26 years. Tobacco and alcohol consumption were reported by 85.3% and 63.5% of patients, respectively. The most commonly affected location was the tongue (42.5%), with lesions exhibiting ulcerous aspects in 87.9% of cases and pain at the time of diagnosis in 70.4% of cases. One hundred sixty-one (82.1%) patients had advanced-stage (III/IV) OSCC. Surgery was the most common treatment option, and the overall 5-year survival rate was 58.5%. Univariate analysis showed that the predictors of poor prognosis were clinical aspect, size, regional metastasis, clinical stage, and treatment. In Uruguay, OSCC is diagnosed late, which is associated with a low survival rate. Educational and preventive measures and investment to improve early diagnosis should be undertaken.
journal_name
Braz Oral Resjournal_title
Brazilian oral researchauthors
Oliveira ML,Wagner VP,Sant'ana Filho M,Carrard VC,Hugo FN,Martins MDdoi
10.1590/1807-3107BOR-2015.vol29.0075subject
Has Abstractpub_date
2015-01-01 00:00:00eissn
1806-8324issn
1807-3107pii
S1806-83242015000100270journal_volume
29pub_type
杂志文章abstract：:The aim of our study was to isolate populations of keratinocyte stem cells based on the expression of cell surface markers and to investigate whether the culture could affect their phenotype. keratinocytes from human oral mucosa were sorted based on the expression of the epithelial stem cell markers p75NTR and CD71. W...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/1807-3107bor-2020.vol34.0033
更新日期：2020-04-06 00:00:00
abstract：:The odontogenic keratocyst (OKC) is a recurrent cyst that has been recently reclassified from an odontogenic tumor to an odontogenic cyst. The aim of the present study was to investigate its treatment and address issues related to its association with nevoid basal cell carcinoma syndrome (NBCCS). Lesions from the coho...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/1807-3107bor-2017.vol31.0098
更新日期：2017-12-18 00:00:00
abstract：:Human Papilomaviruses (HPV) are a group of viruses associated with benign and malignant lesions of cutaneous and mucosal epithelia. Some "high risk" HPV types, especially HPV 16 and 18, are strongly correlated with cervical and anogenital cancers and are also related to the genesis of oral squamous cell carcinomas (OS...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/s1806-83242006000100005
更新日期：2006-01-01 00:00:00
abstract：:Anti-dentin autoantibodies are associated with inflammatory root resorption in permanent teeth and are modulated by dental trauma and orthodontic force. However, it is not known whether deciduous tooth trauma can stimulate the development of a humoral immune response against dentin. The aim of this study was to evalua...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/1807-3107BOR-2015.vol29.0102
更新日期：2015-01-01 00:00:00
abstract：:Epidemiological data on the periodontal health and oral hygiene practices of young individuals in Latin America are limited. This study was conducted in a sample of 355 first-year students randomly selected from 3,251 new students entering the largest university in Colombia. Participants received a periodontal examina...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/1807-3107bor-2014.vol28.0009
更新日期：2014-01-01 00:00:00
abstract：:The aim of this study was to verify the prevalence of dental fluorosis in schoolchildren aged 6 to 15 and its possible association with the impacts on their daily activities. This study is observational, cross-sectional and analytical. A total of 513 schoolchildren from the city of Pinheiro Preto, SC, took part in thi...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/s1806-83242005000200014
更新日期：2005-04-01 00:00:00
abstract：:The purpose of this study was to evaluate the effects of segmental osteotomy on the blood vessels and osteoclasts in rats using micro-computed tomography (micro-CT) and histomorphometric analysis. After segmental osteotomy was performed around the maxillary first molars of 36 male Sprague-Dawley rats (n = 72), the sam...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/1807-3107BOR-2016.vol30.0132
更新日期：2016-11-28 00:00:00
abstract：:School and family together play an important role in the individual development of children. Therefore, this study aimed at evaluating the practices and attitudes towards oral health care of 245 education professionals working in 24 public municipal pre-schools in Niterói, State of Rio de Janeiro, Brazil. The data wer...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/s1806-83242008000400010
更新日期：2008-10-01 00:00:00
abstract：:The aim of this study was to detect possible differences in the EMG (electromyography) activity, chewing rate (CR), cycle duration (CD) and preferred chewing side (PCS) between children with and without unilateral posterior crossbite. Thirty-seven children aged from 7 to 10 years were selected from the clinic of the D...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/s1806-83242010000200013
更新日期：2010-04-01 00:00:00
abstract：:The objective of the present study was to assess the effectiveness of reciprocating instrumentation in disinfecting oval-shaped root canals infected with Enterococcus faecalis. Forty-five human lower premolars were infected with a culture of E. faecalis (ATCC 29212) for 28 days. Five other teeth that were neither cont...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/1807-3107BOR-2015.vol29.0027
更新日期：2015-01-01 00:00:00
abstract：:Gingival overgrowth (GO) is a frequent finding in patients treated with cyclosporine (CsA). This study investigated the prevalence and severity of GO in patients who received kidney transplant and CsA therapy, as well as associations with pharmacological and clinical factors. This cross-sectional study included 63 kid...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/s1806-83242011005000016
更新日期：2012-01-01 00:00:00
abstract：:The objective of this study was to create and evaluate a routine (macro) using Image-Pro Plus 4.5 software (Media Cybernetics, Silver Spring, USA) for automatic counting of labeled nuclei by proliferating cell nuclear antigen (PCNA) immunohistochemistry. A total of 154 digital color images were obtained from eleven se...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/s1806-83242004000200002
更新日期：2004-04-01 00:00:00
abstract：:The effect of contextual factors on dental care utilization was evaluated after adjustment for individual characteristics of Brazilian preschool children. This cross-sectional study assessed 639 preschool children aged 1 to 5 years from Santa Maria, a town in Rio Grande do Sul State, located in southern Brazil. Partic...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/1807-3107BOR-2017.vol31.0027
更新日期：2017-03-30 00:00:00
abstract：:Properly performed daily mechanical biofilm control is the most important prevention strategy for periodontal diseases. However, proper mechanical biofilm control is not performed effectively by the majority of the population, mainly due to lack of motivation and of manual dexterity. Local biofilm retention factors ma...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/1807-3107bor-2014.vol28.0021
更新日期：2014-07-11 00:00:00
abstract：:This randomized clinical trial aimed to assess the efficacy of sealing occlusal carious lesions in permanent teeth. The sample consisted of 54 occlusal carious lesions in permanent molars and premolars of 49 patients aged 8-43 years (median: 19 years). The inclusion criteria comprised the presence of a cavity with no ...
journal_title：Brazilian oral research
pub_type： 杂志文章,随机对照试验
doi：10.1590/1807-3107BOR-2017.vol31.0044
更新日期：2017-06-05 00:00:00
abstract：:Human Papillomavirus (HPV) has considerable tropism for epithelial and mucosal tissues and can therefore be found in several anatomical sites, including the oral cavity. This study aimed to investigate the presence of HPV-DNA and the most frequent viral types in patients using full dentures, compare to patients not us...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/1807-3107bor-2019.vol33.0091
更新日期：2019-11-25 00:00:00
abstract：:Free gingival grafting, the most predictable technique to increase the keratinized gingiva, leaves an open wound on the palate and the resulting discomfort during the healing phase is a significant concern. This study was intended to evaluate the effect of topical erythropoietin on healing of the donor site. Twelve pa...
journal_title：Brazilian oral research
pub_type： 杂志文章,随机对照试验
doi：10.1590/1807-3107bor-2018.vol32.0055
更新日期：2018-06-11 00:00:00
abstract：:Clinical aspects and biochemical properties in the saliva of 21 patients prior to and following radiotherapy for head and neck cancer were evaluated (experimental group) and compared with the same properties in a control group of 21 subjects free of cancer. Salivary flow was evaluated by measuring the time necessary, ...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/s1806-83242004000100013
更新日期：2004-01-01 00:00:00
abstract：:Simvastatin, a drug used to lower blood cholesterol, has been reported to have an anabolic effect on bone. The purpose of this study was to evaluate the influence of simvastatin and demineralized bovine bone matrix (DBBM) on the repair of rat calvarial defects. Defects of 5 mm were created in 64 rats, divided into fou...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/s1806-83242011000100008
更新日期：2011-01-01 00:00:00
abstract：:The aim of the present transversal study was to evaluate the clinical and biochemical salivary parameters of children with and without erosive tooth wear (ETW). The study population was children aged 4 to 9 years. A trained and calibrated examiner (kappa value for intraexaminer reliability = 0.89) classified the child...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/1807-3107bor-2020.vol34.0115
更新日期：2020-09-04 00:00:00
abstract：:The aim of this study was to investigate the prevalence of oral and maxillofacial lesions among children from representative regions of Brazil. A retrospective descriptive study was conducted. Biopsy records comprising the period from 2000 to 2015 were obtained from the archives of three Brazilian oral pathology refer...
journal_title：Brazilian oral research
pub_type： 杂志文章,多中心研究
doi：10.1590/1807-3107bor-2018.vol32.0020
更新日期：2018-03-15 00:00:00
abstract：:Halitosis or bad breath is an oral health condition characterized by unpleasant odors emanating consistently from the oral cavity. The origin of halitosis may be related both to systemic and oral conditions, but a large percentage of cases, about 85%, are generally related to an oral cause. Causes include certain food...
journal_title：Brazilian oral research
pub_type： 杂志文章,评审
doi：10.1590/s1806-83242008000500007
更新日期：2008-01-01 00:00:00
abstract：:The aim of the study was to test whether the filler composition of resin composites influences their flexural strength and modulus of elasticity. Flexural strength and modulus of elasticity were obtained through a three-point bending test. Twelve bar shaped specimens of 5 commercially available composites--Supreme (3M...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/s1806-83242007000100003
更新日期：2007-01-01 00:00:00
abstract：:Although malocclusions represent a serious public health issue, there is insufficient information about this problem in adolescents in Brazil, especially in poorer areas. The purpose of this cross-sectional study was to estimate the prevalence of facial alterations, dental malocclusions, and deleterious oral habits (D...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/s1806-83242012005000027
更新日期：2013-01-01 00:00:00
abstract：:This investigation aims to discuss the methodologies applied in clinical trials published about Carisolv, in order to assess the best scientific evidence concerning chemo-mechanical caries removal. Papers concerning the use of Carisolv were sought using a search strategy. The titles and abstracts of all the reports id...
journal_title：Brazilian oral research
pub_type： 杂志文章,评审
doi：10.1590/s1806-83242006000400015
更新日期：2006-10-01 00:00:00
abstract：:In spite of decades of research on fluoride and the recognition of its role as the cornerstone of dental caries reduction in the last fifty years, questions still arise on its use at community, self-applied and professional application levels. Which method of fluoride delivery should be used? How and when should it be...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/s1806-83242010000500003
更新日期：2010-01-01 00:00:00
abstract：:The aim of this study was to evaluate the effects of different root canal filling techniques on the bond strength of epoxy resin-based sealers. Sixty single-rooted canines were prepared using ProTaper (F5) and divided into the following groups based on the root filling technique: Lateral Compaction (LC), Single Cone (...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/1807-3107BOR-2016.vol30.0024
更新日期：2016-01-01 00:00:00
abstract：:The purpose of this double-blind, randomized, crossover in situ study is to compare remineralization of preformed enamel lesions by casein phosphopeptide-stabilized amorphous calcium phosphate (CPP-ACP) and fluoride dentifrice products. During each of four 10-day experimental legs, 10 participants wore intraoral remov...
journal_title：Brazilian oral research
pub_type： 杂志文章,随机对照试验
doi：10.1590/1807-3107bor-2020.vol34.0061
更新日期：2020-06-24 00:00:00
abstract：:The purpose of this study was to test the hypothesis that both human and bovine sclerotic dentin have similar hardness properties, in addition to similar micromorphological characteristics. Sixteen teeth (8 human and 8 bovine) exhibiting exposed dentin in the incisal edge and showing characteristics typical of scleros...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/s1806-83242011000300014
更新日期：2011-05-01 00:00:00
abstract：:The aim of this study was to evaluate patient perception of surgical discomfort in third molar surgery and the association with clinical variables and polymorphisms associated with the FKBP5, SLC6A4, and COMT genes. This cross-sectional observational study was carried out on 196 participants aged between 18 and 64 yea...
journal_title：Brazilian oral research
pub_type： 杂志文章
doi：10.1590/1807-3107bor-2021.vol35.0007
更新日期：2020-11-13 00:00:00
