Low prevalence of gingival overgrowth associated to new imunossupressive protocols with cyclosporin.

Abstract:

:Gingival overgrowth (GO) is a frequent finding in patients treated with cyclosporine (CsA). This study investigated the prevalence and severity of GO in patients who received kidney transplant and CsA therapy, as well as associations with pharmacological and clinical factors. This cross-sectional study included 63 kidney transplant recipients who were treated with CsA in a university hospital. Demographic, pharmacological, and periodontal data were collected. The primary variable was GO. Independent sample t- and chi-square tests were used to compare means in groups with versus without GO. The response rate was 86.3%. Overall, 40% of patients had some degree of GO. Eleven individuals presented GO scores > 10%, and 5 individuals reached 30%. The mean GO percentage was low (6.79 ± 15.83). Patients that were concurrently under nifedipine treatment showed a non-significant trend toward a greater prevalence of GO. Mean CsA dosage and serum levels were 3.20 ± 0.94 mg/kg/d and 156.12 ± 162.75 ng/mL, respectively. There were no statistically significant differences between patients with versus without GO nor between the groups receiving nifedipine, no drug, or verapamil. The GO prevalence and severity rates were lower than those reported in previous studies and seemed to be independent of drug interactions.

journal_name

Braz Oral Res

journal_title

Brazilian oral research

authors

Wentz LA,Oliveira SC,Moreira CH,Rösing CK

doi

10.1590/s1806-83242011005000016

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

64-70

issue

1

eissn

1806-8324

issn

1807-3107

pii

S1806-83242012000100011

journal_volume

26

pub_type

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