Abstract:
:Clinical aspects and biochemical properties in the saliva of 21 patients prior to and following radiotherapy for head and neck cancer were evaluated (experimental group) and compared with the same properties in a control group of 21 subjects free of cancer. Salivary flow was evaluated by measuring the time necessary, in seconds, for the output of 2 ml of stimulated saliva; and the buffering capacity changes were determined using a simple colorimetric method. Total salivary protein concentration was determined by the Bradford 4 method. Amylase activity was measured by reducing sugars released from a soluble starch substrate, quantified by the dinitrosalicylic method. The electrophoretic profile was evaluated in polyacrylamide gel (12% SDS-PAGE) using samples of 5 mg of salivary protein. A statistically significant reduction (p < 0.01) of the salivary flow was observed, (162.47 s +/- 28.30 before and 568.71 s +/- 79.75 after irradiation), as well as a reduction in the salivary buffering capacity (pH 5.45 +/- 0.14 before and pH 4.40 +/- 0.15 after irradiation). No statistically significant alteration was observed in total salivary protein concentration. A statistically significant reduction (p < 0.01) of salivary alpha-amylase activity (856.6 ng/mg +/- 88.0 before and 567.0 ng/mg +/- 120.6 after irradiation) was observed. Electrophoretic profile differences in salivary protein bands were also observed after radiotherapy, mainly in the range of molecular weight of 72000 to 55000 Daltons. Clinically, patients presenting xerostomia induced by radiotherapy presented an increase in oral tissue injury.
journal_name
Braz Oral Resjournal_title
Brazilian oral researchauthors
de Barros Pontes C,Polizello AC,Spadaro ACdoi
10.1590/s1806-83242004000100013subject
Has Abstractpub_date
2004-01-01 00:00:00pages
69-74issue
1eissn
1806-8324issn
1807-3107pii
S1517-74912004000100013journal_volume
18pub_type
杂志文章abstract::To evaluate the torsional properties of engine-driven pathfinding instruments manufactured from different NiTi alloys - R-Pilot (tip size 12.5;.04 taper; M-Wire) and One G (tip size 14;.03 taper; Conventional NiTi). A total of 40 NiTi instruments from engine-driven pathfinding instruments (n = 20) were used. The torsi...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/1807-3107bor-2019.vol33.0097
更新日期:2019-10-28 00:00:00
abstract::The purpose of this study was to evaluate whether the use of desensitizing dentifrices used 15 days prior to and after in-office tooth bleaching could eliminate or reduce tooth sensitivity. After institutional review board approval and informed consent, 45 subjects were selected and divided into 3 groups according to ...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/S1806-83242013000600012
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abstract::The sense of coherence (SOC) is a measure of global orientation regarding the ability of individuals to cope with stressful situations. The aim of the present study was to evaluate the association between SOC and quality of life (QoL) and clinical and sociodemographic characteristics among survivors of oral, oropharyn...
journal_title:Brazilian oral research
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abstract::There is a clear reported association between social disparity and oral health, for example, between dental caries and malnutrition in children. This fact is detected in several studies, and also found amongst the Brazilian population. However, several efforts have been made to improve the quality of life of the popul...
journal_title:Brazilian oral research
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abstract::The effect of contextual factors on dental care utilization was evaluated after adjustment for individual characteristics of Brazilian preschool children. This cross-sectional study assessed 639 preschool children aged 1 to 5 years from Santa Maria, a town in Rio Grande do Sul State, located in southern Brazil. Partic...
journal_title:Brazilian oral research
pub_type: 杂志文章
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abstract::Conventional methods of caries detection, including the gold standard of histological examination, have certain disadvantages that must be addressed prior to validating any other diagnostic technique-current or new. Here we evaluated the validity of micro-computed tomography (micro-CT) as an alternative gold-standard ...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/1807-3107BOR-2015.vol29.0132
更新日期:2015-01-01 00:00:00
abstract::Non-inferiority randomized clinical trials are indicated when it is intended to prove that an experimental group is not inferior to a control group by more than a margin of non-inferiority. However, this type of study differs from traditional randomized clinical trials (superiority studies) because they have particula...
journal_title:Brazilian oral research
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abstract::School and family together play an important role in the individual development of children. Therefore, this study aimed at evaluating the practices and attitudes towards oral health care of 245 education professionals working in 24 public municipal pre-schools in Niterói, State of Rio de Janeiro, Brazil. The data wer...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/s1806-83242008000400010
更新日期:2008-10-01 00:00:00
abstract::Recent studies investigating protease-activated receptor type 2 (PAR-2) suggest an association between the receptor and periodontal inflammation. It is known that gingipain, a bacterial protease secreted by the important periodontopathogen Porphyromonas gingivalis can activate PAR-2. Previous studies by our group foun...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/1807-3107BOR-2017.vol31.0016
更新日期:2017-01-26 00:00:00
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journal_title:Brazilian oral research
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doi:10.1590/1807-3107BOR-2017.vol31.0089
更新日期:2017-11-06 00:00:00
abstract::Properly performed daily mechanical biofilm control is the most important prevention strategy for periodontal diseases. However, proper mechanical biofilm control is not performed effectively by the majority of the population, mainly due to lack of motivation and of manual dexterity. Local biofilm retention factors ma...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/1807-3107bor-2014.vol28.0021
更新日期:2014-07-11 00:00:00
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journal_title:Brazilian oral research
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doi:10.1590/s1806-83242010000500003
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abstract::The purpose of this study was to evaluate the inflammatory and cure events of acid-based reactions using glass ionomer cement used for cementation of crowns, bridges, onlays and orthodontic bands implanted in subcutaneous tissue, at different time intervals. A total of 48 male Wistar rats were used, distributed into 4...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/S1806-83242014.50000003
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abstract::This study evaluated the effects of 10% alphatocopherol on the fracture resistance of endodontically treated teeth subjected to tooth bleaching with hydrogen peroxide and immediately restored with composite resin. Fifty bovine incisors were selected, including 10 sound teeth that constituted the control group (G1 (C))...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/1807-3107BOR-2016.vol30.0069
更新日期:2016-05-20 00:00:00
abstract::Questionnaires for the assessment of knowledge and self-perception can be useful to diagnose what a dentist knows about management and administration. The aim of the present study was to create and validate the Dental Management Survey Brazil (DMS-BR) scale, based on meetings with experts in the field. After having el...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/1807-3107BOR-2017.vol31.0026
更新日期:2017-04-10 00:00:00
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journal_title:Brazilian oral research
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doi:10.1590/s1806-83242004000300013
更新日期:2004-07-01 00:00:00
abstract::The aim of the study was to test whether the filler composition of resin composites influences their flexural strength and modulus of elasticity. Flexural strength and modulus of elasticity were obtained through a three-point bending test. Twelve bar shaped specimens of 5 commercially available composites--Supreme (3M...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/s1806-83242007000100003
更新日期:2007-01-01 00:00:00
abstract::This research evaluated the bone repair process in surgical defects created on the parietal bones of diabetic rabbits using the guided bone regeneration technique to observe the effects of alloxan in the induction of diabetes mellitus. Twenty-four adult rabbits were divided into three study groups: control (C), diabet...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/s1806-83242008000200015
更新日期:2008-04-01 00:00:00
abstract::The use of acid etchants to produce surface demineralization and collagen network exposure, allowing adhesive monomers interdiffusion and consequently the formation of a hybrid layer, has been considered the most efficient mechanism of dentin bonding. The aim of this study was to compare the tensile bond strength to d...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/s1806-83242007000100014
更新日期:2007-01-01 00:00:00
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journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/1807-3107bor-2014.vol28.0038
更新日期:2014-01-01 00:00:00
abstract::Epidemiological data on the periodontal health and oral hygiene practices of young individuals in Latin America are limited. This study was conducted in a sample of 355 first-year students randomly selected from 3,251 new students entering the largest university in Colombia. Participants received a periodontal examina...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/1807-3107bor-2014.vol28.0009
更新日期:2014-01-01 00:00:00
abstract::[This corrects the article doi: 10.1590/1807-3107BOR-2017.vol31.0105]. ...
journal_title:Brazilian oral research
pub_type: 杂志文章,已发布勘误
doi:10.1590/1807-3107BOR-2017.vol31.0105erratum
更新日期:2018-02-01 00:00:00
abstract::Fluoride has been widely used in dentistry because it is a specific and effective caries prophylactic agent. However, excess fluoride may represent a hazard to human health, especially by causing injury to genetic material. Genotoxicity tests represent an important part of cancer research to assess the risk of potenti...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/s1806-83242004000300003
更新日期:2004-07-01 00:00:00
abstract::To assess the impact of oral conditions on the oral health-related quality of life (OHRQoL) of pediatric liver transplant candidates. This cross-sectional study included 60 children aged 13 to 48 months who were liver transplant candidates that attended the AC Camargo Cancer Center, São Paulo, Brazil. On the day of or...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/1807-3107bor-2020.vol34.0100
更新日期:2020-01-01 00:00:00
abstract::Based on aroeira's (Myracrodruon urundeuva) antimicrobial activity and a future trend to compose intracanal medication, the aim of this study was to assess in vivo inflamatory tissue response to the extracts by edemogenic and histological analysis containing inactivated facultative and anaerobic microorganisms. For ed...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/1807-3107bor-2018.vol32.0042
更新日期:2018-05-24 00:00:00
abstract::There are many limitations to image acquisition, using conventional radiography, of the temporomandibular joint (TMJ) region. The Computed Tomography (CT) scan is a better option, due to its higher accuracy, for purposes of diagnosis, surgical planning and treatment of bone injuries. The aim of the present study was t...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/s1806-83242010000400016
更新日期:2010-10-01 00:00:00
abstract::The present study evaluated the antimicrobial activity of three root canal irrigants against Enterococcus faecalis, Candida albicans, and Staphylococcus aureus. These microorganisms were incubated in the presence of citric acid (6 and 10%), EDTA (17%), and NaOCl (0.5, 1.0, 2.5, and 5.25%). Agar diffusion tests were pe...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/s1806-83242010000400006
更新日期:2010-10-01 00:00:00
abstract::This investigation aims to discuss the methodologies applied in clinical trials published about Carisolv, in order to assess the best scientific evidence concerning chemo-mechanical caries removal. Papers concerning the use of Carisolv were sought using a search strategy. The titles and abstracts of all the reports id...
journal_title:Brazilian oral research
pub_type: 杂志文章,评审
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更新日期:2006-10-01 00:00:00
abstract::This study aimed to evaluate the role of photobiomodulation (PBM) in apexification and apexogenesis of necrotic rat molars with an open apex. Rat molars were exposed to the oral environment for 3 weeks. Canals were rinsed with 2.5% NaOCl and 17% EDTA, filled with antibiotic paste and sealed. After 7 days, canals were ...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/1807-3107bor-2019.vol33.0084
更新日期:2019-08-26 00:00:00
abstract::Gingival overgrowth (GO) is a frequent finding in patients treated with cyclosporine (CsA). This study investigated the prevalence and severity of GO in patients who received kidney transplant and CsA therapy, as well as associations with pharmacological and clinical factors. This cross-sectional study included 63 kid...
journal_title:Brazilian oral research
pub_type: 杂志文章
doi:10.1590/s1806-83242011005000016
更新日期:2012-01-01 00:00:00